Growth hormone (GH) and atherosclerosis: Changes in morphology and function of major arteries during GH treatment

Growth Hormone and IGF Research

Volumn 9, Issue SUPPL. A, 1999, Pages 25-30

  Pfeifer, M ^a   Verhovec, R ^a   Zizek, B ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Carotid and brachial arteries; Flow mediated endothelium dependent dilation; Growth hormone deficiency; Growth hormone treatment; Intima media thickness

Indexed keywords

GROWTH HORMONE; HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ADULT; ARTERY COMPLIANCE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BRACHIAL ARTERY; CAROTID ARTERY; CAROTID ARTERY BIFURCATION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPOPITUITARISM; INSULIN BLOOD LEVEL; MALE; PRIORITY JOURNAL; VASCULAR DISEASE;

EID: 0032982393     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-6374(99)80006-9     Document Type: Conference Paper

References (32)

1. de Boer H. Blok G.J. van der Veen E.A. Clinical aspects of growth hormone deficiency in adults Endocr Rev 16 1995 63 86
2. Caroll P.V. Christ E.R. Growth Hormone Research Society Scientific Committee Growth hormone deficiency in adulthood and the effect of growth hormone replacement: a review J Clin Endocrinol Metab 83 1998 382 395
3. Wuster C. Slenczka E. Ziegler R. Increased prevalence of osteoporosis and arteriosclerosis in patients with conventionally substituted pituitary insufficiency: is there a need for additional growth hormone substitution? Min Wochenschr 69 1991 769 773
4. Markussis V. Beshyah S.A. Fisher C. Sharp P. Nicolaides A.N. Johnston D.G. Detection of premature atherosclerosis by high resolution ultrasonography in symptom free hypopituitary adults Lancet 340 1992 1188 1192
5. Johansson J.O. Fowelin J. Landin K. Larger J. Bengtsson B.A. Growth hormone deficient adults are insulin resistant Metabolism 44 1995 1126 1129
6. Hwu C.-M. Kwok C.F. Lai T.-Y. Growth hormone (GH) replacement reduces body fat and normalises insulin sensitivity in GH deficient adults: a report of one year clinicalexperience J Clin Endocrinol Metab 82 1997 3285 3292
7. Rosen T. Bengtsson B.A. Premature mortality due to cardiovascular disease in hypopituitarism Lancet 336 1990 285 288
8. Bülow B. Hagmar L. Mikoczy Z. Nordstrom C.H. Erfurth E.M. Increased cerebrovascular mortality in patients with hypopituitarism Clin Endocrinol 46 1997 75 81
9. Bates A.S. Van't Hoff W. Jones P.J. Clayton R.N. The effect of hypopituitarism on life expectancy J Clin Endocrinol Metab 81 1996 1169 1172
10. (Suppl) Bates A.S. Bullivant B. Clayton R.N. Sheppard M.C. Stewart P.M. Increased mortality in hypopituitarism is not due to an increase in vascular mortality J Endocrinol 152 1997 OC9
11. Markussis V. Beshyah S.A. Fisher C. Parker K.H. Nicolaides A.N. Johnston D.G. Abnormal carotid arterial wall dynamics in symptom free hypopituitary adults Eur J Endocrinol 136 1997 157 164
12. Lehmann E.D. Hopkins K.D. Weissberger A.J. Gosling R.G. Sonksen P.H. Aortic distensibility in growth hormone deficient adults Lancet 341 1993 309
13. Salonen J.T. Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerosis progression Circulation 87 Suppl II 1993 56 65
14. Capaldo B. Patti L. Oliviero U. Increased arterial intima-media thickness in childhood onset growth hormone deficiency J Clin Endocrinol Metab 82 1997 1378 1381
15. Pfeifer M. Verhovec R. Zizek B. Prezelj J. Poredos P. Clayton R.N. Growth hormone treatment reverses early atherosclerotic changes in growth hormone deficient adults J Clin Endocrinol Metab 84 1999 453 457
16. Seville. ORl-1 (Abstract) Evans L.M. Davies J.S. Rees J.A.E. Scanlon M.E. Endothelial dysfunction in adult growth hormone deficiency Proceedings of the 4th European Congress of Endocrinology 1998
17. Celermajer D.S. Sorensen K.E. Georgakopoulos D. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium dependent dilation in healthy young adults Circulation 88 1993 2149 2154
18. Geroulakos G. O'Gorman D. Nicolaides A. Sheridan D. Elkeles R.S. Sharper A.G. Carotid intima-media thickness: correlation with the British Regional Heart Study risk score J Intern Med 235 1994 431 433
19. Grobbee D. Bots M. Carotid artery intima-media thickness as an indicator of generalised atherosclerosis J Intern Med 236 1994 567 573
20. Wilson P.W.F. Hoeg J.N. D'Agostino R.B. Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis N Engl J Med 337 1997 516 522
21. Gamble G. Zom J. Sanders G. MacMahon S. Sharpe N. Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery Stroke 25 1994 11 16
22. Boger R.H. Skamira C. Bode-Boger S.M. Brabant G. von zur Muhlen A. Frolich J.C. Nitric oxide may mediate the haemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency J Clin Invest 98 1996 2706 2713
23. (Suppl) Radomski M.W. Salas E. Nitric oxide — biological mediator, modulator and factor of injury: its role in the pathogenesis of atherosclerosis Atherosclerosis 118 1995 569 580
24. Cooke J.P. Singer A.H. Tsao P. Zera P. Rowan R.A. Billingham M.E. Antiatherosclerotic effect of L-arginine in the hypercholesterolaemic rabbit J Clin Invest 90 1992 1168 1172
25. Candipan R.C. Wang B. Buitrago R. Tsao P.S. Cooke J.P. Regression or progression. Dependency on vascular nitric oxide Atheroscler Thromb Vasc Biol 16 1995 44 50
26. Singer A.H. Tsao P.S. Wang B.-Y. Bloch D.A. Cooke J.P. Discordant effects of dietary l -arginine on vascular structure and reactivity in hypercholesterolaemic rabbits J Cardiovasc Pharm 25 1995 710 717
27. Boger R.H. Bode-Boger S.M. Kienke S. Stan A.C. Nafe R. Frolich J.C. Dietary l -arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbits Atherosclerosis 136 1998 67 77
28. Theilmeier G. Chan J.R. Zalpour C. Adhesiveness of mononuclear cells in hypercholesterolaemic humans is normalised by dietary l -arginine Arterioscler Thromb Vasc Biol 17 1997 3557 3564
29. Wolf A. Zalpour C. Theilmeier G. Dietary l -arginine supplementation normalises platelet aggregation in hypercholesterolaemic humans J Am Coll Cardiol 29 1997 478 485
30. Tsukahara H. Gordienko D.V. Tonshoff B. Gelato M.C. Goligorsky M.S. Direct demonstration of insulin-like growth factor 1 induced nitric oxide production by endothelial cells Kidney Int 45 1994 598 604
31. Wu H.Y. Yue C.J. Chyu K.Y. Hsuch W.A. Chan T.M. Endothelium dependent vascular effects of insulin and insulin-like growth factor I in the perfused rat mesenteric artery and aortic ring Diabetes 43 1994 1027 1032
32. Bar R.S. Boes M. Dake B.L. Booth B.A. Henley S.A. Sandra A. Insulin, insulin-like growth factors, and vascular endothelium Am J Med 85 Suppl 5a 1988 59 70