Interaction of ivermectin with γ-aminobutyric acid receptors in Trichinella spiralis muscle larvae

Parasitology Research

Volumn 85, Issue 4, 1999, Pages 320-323

  Ros Moreno, R M ^a   Moreno Guzman M J ^a   Jimenez Gonzalez A ^a   Rodriguez Caabeiro F ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

GABA receptor; Ivermectin; Nematodes; Trichinella spiralis

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; IVERMECTIN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; HOST PARASITE INTERACTION; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; SWINE; TRICHINELLA SPIRALIS;

ANIMALIA; NEMATODA; SUS SCROFA; TRICHINELLA SPIRALIS;

EID: 0032980478     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050555     Document Type: Article

References (21)

1. Arena JP, Liu KK, Paress PS, Cully DF (1991) Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. Mol Pharmacol 40: 368-374
2. Arena JP, Liu KK, Paress PS, Schaeffer JM, Cully DF (1992) Expression of a glutamate-activated chloride current in Xenopus oocytes infected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. Mol Brain Res 15: 339-348
3. Brand T, Weistein P, Mehland B, Weinbach E (1952) Observation on the metabolism of bacteria-free larvae of Trichinella spiralis. Exp Parasitol 1: 245-255
4. Brownlee DJA, Holden-Dye L, Walker RJ (1997) Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode Ascaris suum. Parasitology 115: 553-561
5. Campbell WC (1985) Ivermectin: an update. Parasitol Today 1: 10-176
6. Criado-Fornelio A, Rodriguez-Caabeiro F, Jimenez-Gonzalez A (1986) Efectos "in vivo" e "in vitro" de ivermectina sobre las actividades succinato deshidrogenasa y fumarato reductasa en Trichinella spiralis. Rev Iber Parasitol 46, 425-429
7. Cully DF, Paress PS (1991) Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans Mol Pharmacol 40: 326-332
8. 1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Proc Natl Acad Sci USA 4: 2062-2066
9. Gill JH, Redwin JM, VanWyk JA, Lacey E (1995) Avermectin inhibition of larval development in Haemonchus contortus - effects of ivermectin resistance, Int J Parasitol 25: 463-470
10. Holden-Dye L, Walker RJ (1990) Avermectin and avermectin deivates are antagonists at the γ-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris. Is this the site of anthelmintic action? Parasitology 101: 265-271
11. Huang J, Casida JC (1997) Avermectin Bla binds to high- and low- affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured granule neurons. J Pharmacol Exp Ther 281: 261-266
12. 1a : a paralyzing anthelmintic that affects interneurons and inhibitory motorneurons in Ascaris. Proc Natl Acad Sci USA 77: 6211-6215
13. Krausse RM, Buisson B, Bertrand S, Corringer PJ, Galzi JL, Changeux JP, Bertrand D (1998) Ivermectin: a positive allosteric effector of the alpha 7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53: 283-294
14. Lejambre LF, Gill JH, Lenane IJ, Lacey E (1995) Characterization of an avermectin resistant strain of australian Haemonchus contortus. Int J Parasitol 25: 691-698
15. Lowry H, Rosenbrough N, Farr A, Randall R (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
16. 1a ; stimulation of release of GABA from brain synaptosomes. J Neurochem 34: 351-358
17. Rohrer SP, Evans WD, Bergstrom AR (1990) A membrane associated glutamate binding protein from Caenorhabditis elegans and Haemonchus contortus. Comp Biochem Physiol [C] 95: 223-228
18. Rohrer SP, Meinke PT, Hayes EC, Mrozik H, Schaeffer JM (1992) Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. Proc Natl Acad Sci USA 89: 4168-4172
19. Rohrer SP, Birzin ET, Eary CH, Schaeffer JM, Shoom WL (1994) Ivermectin binding sites in sensitive and resistant Haemonchus contortus. J Parasitol 80 493-497
20. Schaeffer JM, Bergstrom AR (1988) Identification of γ-aminobutyric acid and its binding sites in Caenorhabditis elegans. Life Sci 43: 1701-1706
21. Schaeffer JM, Haines HW (1989) Avermectin binding in Caenorhabditis elegans. A two-state model for the avermectin binding site. Biochem Pharmacol 14: 2329-2338