Neurology of saccades and smooth pursuit

Current Opinion in Neurology

Volumn 12, Issue 1, 1999, Pages 13-19

  Gaymard, Bertrand ^a   Pierrot Deseilligny, Charles ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CORTEX; CINGULATE GYRUS; ELECTROPHYSIOLOGY; HUMAN; IMAGING; MOTIVATION; NEUROLOGY; NONHUMAN; PONS RETICULAR FORMATION; REVIEW; SACCADIC EYE MOVEMENT; SMOOTH PURSUIT EYE MOVEMENT; SUPERIOR COLLICULUS; VISUAL FIELD;

ANIMALS; ATTENTION; BRAIN; CEREBELLUM; GYRUS CINGULI; HAPLORHINI; HUMANS; MAGNETIC RESONANCE IMAGING; MEMORY, SHORT-TERM; MOTIVATION; PARIETAL LOBE; RETICULAR FORMATION; SACCADES; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED; VISION;

EID: 0032979137     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199902000-00003     Document Type: Review

References (56)

1. 1 Shafiq R, Stuart GW, Sandbach J, Maruff P, Currie J. The gap effect and express saccades in the auditory modality. Exp Brain Res 1998; 118: 221-229.
2. 2 Fischer B, Weber H. Effects of stimulus conditions on the performance of antisaccades in man. Exp Brain Res 1997; 116:191-200.
3. 3 Pratt J. Visual fixation offsets affect both the initiation and the kinematic features of saccades. Exp Brain Res 1998; 118:135-138.
4. 4 Ploner CJ, Gaymard B, Rivaud S, Agid Y, Pierrot-Deseilligny C. Temporal limits of spatial working memory in humans. Eur J Neurosci 1998; 10: 794-797. This is the first study to use memory-guided saccades which showed that the variability of accuracy decreased (i.e. with an improved response) after a delay of 20 s, suggesting the existence of two different systems successively controlling spatial memory.
5. 5 Gilchrist ID, Brown V, Findlay JM. Saccades without eye movements. Nature 1997; 390:130-131.
6. 6 Sommer MA, Tehovnik EJ. Reversible inactivation of macaque frontal eye field. Exp Brain Res 1997; 116:229-249.
7. 7 Hanes DP, Patterson WF, Schall JD. Role of the frontal eye field in countermanding saccades. Visual movement and fixation activity. J Neurophysiol 1998; 79:817-834. This elegant study shows that saccade triggering depends on a subtle balance between the activity of gaze-shifting and gaze-holding neurones.
8. 8 Burman DD, Bruce CJ. Suppression of task-related saccades by electrical stimulation in the primate's frontal eye field. J Neurophysiol 1997; 77: 2252-2267. This study reveals that inhibitory functions in the FEF exist and may help to suppress or delay voluntary saccades or increase the accuracy of an appropriate saccade.
9. 9 Schlag J, Dassonville P, Schlag-Rey M. Interaction of the two frontal eye fields before saccade onset. J Neurophysiol 1998; 79:64-72.
10. 10 Umeno MM, Goldberg ME. Spatial processing in the monkey frontal eye field. I. Predictive visual responses. J Neurophysiol 1997; 78:1373-1383. Visual cells in the FEF are updated even before the saccade occurs. This early remapping enables the ocular motor system to maintain spatial accuracy before visual reafference.
11. 11 Dassonville P, Schlag J, Schlag-Rey M. The frontal eye field provides the goal of saccadic eye movements. Exp Brain Res 1992; 89:300-310.
12. 12 Fujii N, Mushiake H, Tanji J. Intracortical microstimulation of bilateral frontal eye field. J Neurophysiol 1998; 79:2240-2244.
13. 13 Schiller PH, Chou I-H. The effects of frontal eye field and dorsomedial frontal cortex lesions on visually guided eye movements. Nat Neurosci 1998; 1:248-253.
14. 14 Schlag-Rey M, Amador N, Sanchez H, Schlag J. Antisaccade performance predicted by neuronal activity in the supplementary eye field. Nature 1997; 390:398-401.
15. 15 Mushiake H, Fujii N, Tanji J. Visually guided saccade versus eye-hand reach: contrasting neuronal activity in the cortical supplementary and frontal eye fields. J Neurophysiol 1996; 75:2187-2191.
16. 16 Olson CR, Gettner SN. Object-centered direction selectivity in the macaque supplementary eye field. Science 1995; 269:985-988.
17. 17 Mann SE, Thau R, Schiller PE. Conditional task-related responses in monkey dorsomedial frontal cortex. Exp Brain Res 1988; 69:460-468.
18. 18 Chen LL, Wise SP. Conditional oculomotor learning: population vectors in the supplementary eye field, J Neurophysiol 1997; 78:1160-1163.
19. 19 Colby CL. Action-oriented spatial frames in cortex. Neuron 1998; 20: 15-24.
20. 20 Duhamel JR, Bremmer F, BenHamed S, Graf W. Spatial invariance of visual receptive fields in parietal cortex neurons. Nature 1997; 389:845-848. This is the first demonstration that a head-centred frame of reference exists at the level of single neurones.
21. 21 Gottlieb JP, Kusunoki M, Goldberg ME. The representation of visual salience in monkey parietal cortex. Nature 1998; 391:481-484.
22. 22 Gnadt JW, Beyer J. Eye movements in depth: what does the monkey's parietal cortex tell the superior colliculus? NeuroReport 1998; 9:233-238. Evidence is provided that the parietal eye field is involved in the control of depth-related signals.
23. 23 Carter N, Zee DS. The anatomical localization of saccades using functional imaging studies and transcranial magnetic stimulation. Curr Opin Neurol 1997; 10:10-17.
24. 24 Nobre AC, Sebestyen GN, Gitelman DR, Mesulam MM, Frackowiak RSJ, Frith CD. Functional localization of the system for visuospatial attention using positron emission tomography. Brain 1997; 120:515-533. Visuospatial attention was studied using PET with paradigms resulting in intentional shifts of this process; it is interesting to note that the anterior cingulate cortex, known to be involved in motivation, was activated.
25. 25 Büchel C, Josephs O, Rees G, Turner R. Frith CD, Friston KJ. The functional anatomy of attention to visual motion. A functional MRI study. Brain 1998; 121:1281-1294. Visual attention was studied using functional MRI with paradigms stimulating a large part of the peripheral visual field; it is interesting to note that the superior parietal lobule, known to be involved in peripheral visual attention, was activated.
26. 26 Pierrot-Deseilligny C, Rivaud S, Gaymard B, Müri R, Vermersch AI. Cortical control of saccades. Ann Neurol 1995; 37:557-567.
27. 27 Corbetta M. Frontoparietal cortical networks for directing attention and the eye to visual locations: identical, independent, or overlapping neural systems? Proc Natl Acad Sci USA 1998; 95:831-838.
28. 28 Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118:279-306.
29. 29 Gaymard B, Rivaud S, Cassarini JF, Dubard T, Rancurel G, Agid Y, Pierrot-Deseilligny C. Effects of anterior cingulate cortex lesions on ocular saccades in humans. Exp Brain Res 1998; 120:173-183. This is the first study of patients with small vascular lesions of the anterior cingulate cortex using saccade paradigms; impairment of all intentional saccades occurred because of the role of this area in motivation, which probably consists of an early preparation (i.e. pre-activation) of all frontal ocular motor areas involved in the control of intentional saccades.
30. 30 Bodis-Wollner I, Bucher SF, Seelos KC, Paulus W, Reiser M, Oertel WH. Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades. Neurology 1997; 49:416-420.
31. 31 Lang W, Petit L, Höllinger P. A positron emission tomography study of oculomotor imagery. NeuroReport 1994; 5:921-924.
32. 32 Petit L, Clark VP, Ingeholm J, Haxby JV. Dissociation of saccade-related and pursuit-related activation in human frontal eye fields as revealed by fMRI. J Neurophysiol 1997; 77:3386-3390. This paper reports identification of two areas in the FEF that are activated during saccades or smooth pursuit as shown by functional MRI.
33. 33 Dejardin S, Dubois J, Bodart JM, Schiltz C, Dilinte A, Michel C et al. PET study of human voluntary saccadic eye movements in darkness: effect of task repetition on the activation pattern. Eur J Neurosci 1998; 10: 2328-2336. PET evidence is provided that the SEF is important for the repetition of a motor task, such as saccades.
34. 34 Gaymard B, Rivaud S, Pierrot-Deseilligny C. Role of the left and right supplementary motor areas in memory-guided saccades sequences. Ann Neurol 1993; 34:404-406.
35. 35 Doricchi F, Perani D, Grassi CIF, Bettinardi SCV, Galati Gaspare, Pizzamiglio L, Fazio F. Neural control of fast-regular saccades and antisaccades: an investigation using positron emission tomography. Exp Brain Res 1997; 116:50-62.
36. 36 Brandt SA, Ploner CJ, Meyer BU, Leistner D, Villringer A. Effects of repetitive transcranial magnetic stimulation over dorsolateral prefrontal and posterior parietal cortex on memory guided saccades. Exp Brain Res 1998; 118:197-204. Confirmation using TMS that the posterior parietal cortex is involved early and the prefrontal cortex later in a memory-guided saccade task is provided.
37. 37 Müri R, Vermersch AI, Rivaud S, Gaymard B, Pierrot-Deseilligny C. Effects of single-pulse transcranial magnetic stimulation over the prefrontal and posterior parietal cortices during memory-guided saccades in humans. J Neurophysiol 1996; 76:2102-2106.
38. 38 Zhou W, King WM. Premotor commands encode monocular eye movements. Nature 1998; 393:692-695. Evidence is provided that premotor neurones in the paramedian reticular pontine formation encode monocular commands for either right or left eye saccades, but not conjugate velocity commands (as previously thought), explaining the fact that conjugate saccades in depth exploration may be of very different sizes.
39. 39 Kaneko CRS. Eye movement deficits after ibotenic acid lesions of the nucleus prepositus hypoglossi in monkeys. I. Saccades and fixation. J Neurophysiol 1997; 78:1753-1768. That the nucleus prepositus hypoglossi is involved in the control of integration of lateral eye position and that other structures are also involved in this process is confirmed.
40. 40 Everling S, Paré M, Dorris MC, Munoz DP. Comparison of the discharge characteristics of brain stem omnipause neurons and superior colliculus fixation neurons in monkey: implications for control of fixation and saccade behavior. J Neurophysiol 1998; 79:511-528. This electrophysiological study shows that the superior colliculus fixation neurones lie in the rostral pole of the superior colliculus, discharge during fixation (as do brainstem omnipause neurones), project to the omnipause neurones and are excitatory, but are not the only afferent pathway of omnipause neurones.
41. 41 Gandhi NJ, Keller EL. Spatial distribution and discharge characteristics of superior colliculus neurons antidromically activated from the omnipause region in monkey. J Neurophysiol 1997; 78:2221-2225.
42. 42 Horn AKE, Büttner-Ennever JA. Promotor neurons for vertical eye movements in the rostral mesencephalon of monkey and human: histologic identification by panvalbumin immunostaining. J Comp Neurol 1998; 392: 413-427. This is an interesting anatomical method for separating in humans the rostral interstitial nucleus of the medial longitudinal fasciculus from the INC, these two nuclei being very close to each other.
43. 43 Kaneko CRS, Fukushima K. Discharge characteristics of vestibular saccade neurons in alert monkeys. J Neurophysiol 1998; 79:835-847. This interesting electrophysiological study confirms that the INC is involved during all vertical eye movements and plays a role in the control of vertical eye position integration.
44. 44 Mustari MJ, Fuchs AF, Pong M. Response properties of pretectal omnidirectional pause neurons in the behaving primate. J Neurophysiol 1997; 77: 116-125.
45. 45 Handel ARI, Glimcher PW. Response properties of saccade-related burst neurons in the central mesencephalic reticular formation. J Neurophysiol 1997; 78:2164-2175.
46. 46 Bremmer F, Ilg UJ, Thiele A, Distler C, Hoffmann KP. Eye position effects in monkey cortex. I. Visual and pursuit-related activity in extrastrìate areas MT and MST. J Neurophysiol 1997; 77:944-961.
47. 47 Bremmer F, Ilg UJ, Thiele A, Distler C, Hoffmann KP. Eye position effects in monkey cortex. II. Pursuit- and fixation-related activity in posterior parietal areas LIP and 7A. J Neurophysiol 1997; 77:962-977.
48. 48 Bucher SF, Dieterich M, Seelos KC, Brandt T. Sensorimotor cerebral activation during optokinetic nystagmus. Neurology 1997; 49:1370-1377.
49. 49 Dieterich M, Bucher SF, Seelos KC, Brandt T. Horizontal or vertical optokinetic stimulation activates visual motion-sensitive, ocular motor and vestibular cortex areas with right hemispheric dominance. Brain 1998; 121: 1479-1495.
50. 50 Ohtsuka K, Enoki T. Transcranial magnetic stimulation over the posterior cerebellum during smooth pursuit eye movements in man. Brain 1998; 121: 429-435.
51. 51 Robinson FR, Straube A, Fuchs AF. Participation of caudal fastigial nucleus in smooth pursuit eye movements. II. Effects of muscimol inactivation. J Neurophysiol 1997; 78:848-859.
52. 52 Straube A, Scheuerer W, Eggert T. Unilateral cerebellar lesions affect initiation of ipsilateral smooth pursuit eye movements in humans. Ann Neurol 42: 891-898.
53. 53 Haarmeier T, Thier P, Repnow M, Petersen D. False perception of motion in a patient who cannot compensate for eye movements. Nature 389: 849-852. Parieto-occipital regions are probably involved in the ability to distinguish a real world displacement from an apparent motion due to eye movements.
54. 54 Rivaud-Pechoux S, Dürr A, Gaymard B, Cancel G, Ploner CJ, Agid Y. et al. Eye movement abnormalities correlate with genotype in autosomal dominant cerebellar ataxia type I. Ann Neurol 1998; 43:297-302. This paper reports relatively specific ocular motor abnormalities in three types of SCA.
55. 55 Wessel K, Moschner C, Wandinger KP, Kömpf D, Heide W. Oculomotor testing in the differential diagnosis of degenerative ataxic disorders. Arch Neurol 1998; 55:949-946.
56. 56 Straube A, Mennicken JB, Riedel M, Eggert T, Müller N. Saccades in Gilles de la Tourette's syndrome. Mov Dis 1997; 12:536-546.