Low hemoglobin is associated with increased serum levels of vascular endothelial growth factor (VEGF) in cancer patients. Does anemia stimulate angiogenesis?

Strahlentherapie und Onkologie

Volumn 175, Issue 3, 1999, Pages 93-96

  Dunst, Jürgen ^a   Pigorsch, Steffi ^b   Hänsgen, Gabriele ^b   Hintner, Ingrid ^b   Lautenschläger, Christine ^b   Becker, Axel ^b  

^a MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG   (Germany)

^b NONE

Author keywords

Anemia; Cancer; Hemoglobin; Vascular endothelial growth factor (VEGF)

Indexed keywords

VASCULOTROPIN;

ADULT; AGED; ANEMIA; ANGIOGENESIS; CANCER; CANCER PATIENT; CARCINOMA; HEMOGLOBIN DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; REVIEW;

EID: 0032977983     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02742340     Document Type: Review

References (15)

1. Becker A, Feldmann M, Stadler A, et al. Hemoglobin level and oxygenation of head and neck tumors. Int. J Radiat Oncol Biol Phys 1998;40: Suppl.
2. Claffey KP, Brown LF, del Aguila LF, et al. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 1996;172:172-81.
3. Folkman J. Clinical implications of research on angiogenesis. N Engl J Med 1995;333:1757-63.
4. Glaser C, Millesi W, Gössweiner S, et al. RHu-erythropoetin supply increases efficacy of neo-adjuvant radiochemotherapy in patients with oral squamous cell carcinomas. Proc ASCO 1998.
5. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 1996;379:88-91.
6. Kondo S, Asano M, Matsuo K, et al. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochim Biophys Acta 1994;1221:211-4.
7. Leung DW, Cachianes G, Kuang W-J, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
8. Matern J, Kallinowski F, Herfarth C, et al. Association of resistance-related protein expression with vascularization and low levels of oxygen in human rectal cancer. Int J Cancer 1996;67:20-3.
9. Matern J, Volm M. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumor cell proliferation in human epidermoid lung carcinoma. Br J Cancer 1996;73:931-4.
10. Plate KH, Breier G, Weich HA, et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992;359:845-8.
11. Salven P, Mäenpää H, Orpana A, et al. Serum vascular endothelial growth factor is often elevated in disseminated cancer. Clin Cancer Res 1997;3:647-51.
12. Salven P, Teerenhovi L, Joensuu H. A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood 1997;90:3167-72.
13. Shweiki D, Neeman M, Itin A, et al. Induction of vascular endothelial growth factor expression by hypoxia and by glucose-deficiency in multi-cell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci USA 1995;92:768-72.
14. Shweiki D, Neeman M, Itin A, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-5.
15. Wittekind C, Tannapfel A. Die Entstehung von Metastasen und ihre Klassifikation. Strahlenther Onkol 1996;172:287-94.