Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio)

European Surgical Research

Volumn 31, Issue 3, 1999, Pages 230-239

  Schön, Michael R ^a,d   Heil, W ^b   Lemmens, H P ^a   Padval, D ^b   Matthes, M ^a   Puhl, G ^a   Neuhaus, P ^a   Hammer, C ^c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Amino acids; Dialysis; Extracorporeal liver perfusion; Hepatic encephalopathy; Hepatic failure; Primate; Xenogeneic liver perfusion

Indexed keywords

AMINOTRANSFERASE; AROMATIC AMINO ACID; BRANCHED CHAIN AMINO ACID; ISOLEUCINE; LEUCINE; PHENYLALANINE; TYROSINE; UREA; VALINE;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL TISSUE; ARTICLE; BILE; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER FAILURE; LIVER PERFUSION; NONHUMAN; PHYSIOLOGY; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY; UREA CYCLE;

ALANINE TRANSAMINASE; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE; FEMALE; L-LACTATE DEHYDROGENASE; LIVER; MACACA MULATTA; MALE; PERFUSION; PHENYLALANINE; TIME FACTORS; TYROSINE; UREA;

EID: 0032977340     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000008698     Document Type: Article

References (34)

1. Ferenci P: Pathophysiology of hepatic encephalopathy. Hepatogas-troenterology 1991;38:371-376.
2. O'Grady JG, Alexander GJ, Hayllar KM, Williams R: Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989;97:439-445.
3. Ringe B, Pichlmayr R, Lauchart W, Müller R: Indications and results of liver transplantation in acute hepatic failure. Transplant Proc 1986;18: 86-88.
4. Bismuth H, Samuel D, Gugenheim J, Castaing D, Bernuau J, Rueff B, Benhamou JP: Emergency liver transplantation for fulminant hepatitis. Ann Intern Med 1987;107: 337-341.
5. Starzl TE, Demetris AJ, van Thiel DH: Liver transplantation (1). N Engl J Med 1989;321:1014-1022.
6. Matsubara S: Combination of plasma exchange and continuous hemofiltration as temporary metabolic support for patients with acute liver failure. Artif Organs 1994;18:363-366.
7. Fischer JE, Funovics JM, Aguirre A, James JH, Keane JM, Wesdorp R, Yoshimura N, Westman T: The role of plasma amino acids in hepatic encephalopathy. Surgery 1975;78: 276-290.
8. James JH, Ziparo V, Jeppsson B, Fischer JE: Hyperammonaemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: A unified theory of portal-systemic encephalopathy. Lancet 1979;ii:772-775.
9. Butterworth RF: Neuroactive amino acids in hepatic encephalopathy. Metab Brain Dis 1996;11:165-173.
10. Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB: The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 1976;80: 77-91.
11. Abouna GM, Fisher LM, Porter KA, Andres G: Experience in the treatment of hepatic failure by interemittent liver hemoperfusions. Surg Gynecol Obstet 1973;137:741-752.
12. Tung LC, Häring R, Waldschmidt J, Weber D: Erfahrungen mit der extrakorporalen Leberperfusion bei akutem Leberversagen. Zentralbl Chir 1980;105:1195-1205.
13. Chari RS, Collins BH, Magee JC, DiMaio JM, Kirk AD, Harland RC, McCann RL, Platt JL, Meyers WC: Brief report: Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation. N Engl J Med 1994;331:234-237.
14. Schön MR, Puhl G, Frank J, Neuhaus P: Hemodialysis improves results of pig liver perfusion after warm ischemic injury. Transplant Proc 1993;25:3239-3243.
15. Schön MR, Lemmens HP, Neuhaus P, Baehr P, Heil W, Pöhlein C, Thiery J, Hammer C: Improved xenogeneic extracorporeal liver perfusion. Transplant Proc 1994;26: 1293-1297.
16. Lee WM: Acute liver failure. N Engl J Med 1993;329:1862-1872.
17. Williams R, Wenden J: Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology 1994;20:5-10.
18. Iber FL, Rosen H, Levenson SM, Chalmers TC: The plasma amino acids in patients with liver failure. Nutrition 1993;9:569-578.
19. Record CO, Buxton B, Chase RA, Curzon G, Murray Lyon IM, Williams R: Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy. Eur J Clin Invest 1976;6:387-394.
20. Chase RA, Davies M, Trewby PN, Silk DB, Williams R: Plasma amino acid profiles in patients with fulminant hepatic failure treated by repeated polyacrylonitrile membrane hemodialysis. Gastroenterology 1978;75:1033-1040.
21. Reilly J, Mehta R, Teperman L, Cemaj S, Tzakis A, Yanaga K, Ritter P, Rezak A, Makowka L: Nutritional support after liver transplantation: A randomized prospective study. J Parenter Enteral Nutr 1990;14:386-391.
22. Vilstrup H, Gluud C, Hardt F, Kristensen M, Kohler O, Melgaard B, Dejgaard A, Hansen BA, Krintel JJ, Schütten HJ, et al: Branched chain enriched amino acid versus glucose treatment of hepatic encephalopathy. A double-blind study of 65 patients with cirrhosis. J Hepatol 1990;10:291-296.
23. Gluud C: Branched-chain amino acids for hepatic encephalopathy? Hepatology 1991;13:812-813.
24. Plauth M, Egberts EH, Hamster W, Torok M, Müller PH, Brand O, Furst P, Dolle W: Long-term treatment of latent portosystemic encephalopathy with branched-chain amino acids. A double-blind placebo-controlled crossover study. J Hepatol 1993;17:308-314.
25. Grungreiff K, Kleine FD, Musil HE, Diete U, Franke D, Klauck S, Page I, Kleine S, Lossner B, Pfeiffer KP: Valin and verzweigtkettige Aminosäuren in der Behandlung der hepatischen Enzephalopathie. Z Gastroenterol 1993;31:235-241.
26. Chalasani N, Gitlin N: Severe recurrent hepatic encephalopathy that responded to oral branched chain amino acids. Am J Gastroenterol 1996; 91:1266-1268.
27. Naylor CD, O'Rourke K, Detsky AS, Baker JP: Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A metaanalysis. Gastroenterology 1989;97: 1033-1042.
28. Fabrri A, Magrini N, Bianchi G, Zoli M, Marchesini G: Overview of randomized clinical trials of oral branched-chain amino acid treatment in chronic hepatic encephalopathy. J Parenter Enterai Nutr 1996; 20:159-164.
29. Neuhaus P, Blumhardt G: Extracorporeal liver perfusion: Applications of an improved model for experimental studies of the liver. Int J Artif Organs 1993;16:729-739.
30. Felig P: Amino acid metabolism in man. Annu Rev Biochem 1975;44: 933-955.
31. Schön MR, Hunt CJ, Pegg DE, Wight DG: The possibility of resuscitating livers after warm ischemic injury. Transplantation 1993;56: 24-31.
32. Roth E, Mühlbacher F, Rauhs R, Huk I, Soderland K, Funovics J: Free amino acids in plasma and muscle in fulminant hepatic coma during an extracorporeal liver perfusion. J Parenter Enterai Nutr 1982; 6:240-244.
33. Fischer JE: Branched-chain-enriched amino acid solutions in patients with liver failure: An early example of nutritional pharmacology. J Parenter Enteral Nutr 1990;14: 249S-256S.
34. Miwa Y, Kato M, Moriwaki H, Okuno M, Sugihara J, Ohnishi H, Yoshida T, Muto Y, Nakayama M, Morioka Y, et al: Effects of branched-chain amino acid infusion in protein metabolism in rats with acute hepatic failure. Hepatology 1995;22:291-296.