Antiphospholipid antibodies in obstetrics: New complexities and sites of action

Human Reproduction Update

Volumn 5, Issue 3, 1999, Pages 267-276

  Caruso, A ^a   De Carolis, S ^a   Di Simone, N ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Antiphospholipid syndrome; Fetal loss; Phospholipid antibodies; Placental thrombosis; Trophoblast invasiveness

Indexed keywords

ACETYLSALICYLIC ACID; HEPARIN; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY; POLYCLONAL ANTIBODY; PREDNISONE;

ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNE DISEASE; CELL FUNCTION; DECIDUA; ENDOTHELIUM CELL; FEMALE; FETUS MONITORING; FETUS WASTAGE; HUMAN; OBSTETRICS; PLACENTA; PLACENTA CIRCULATION; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REVIEW; SPONTANEOUS ABORTION; THROMBOSIS; TROPHOBLAST; WELLBEING;

ABORTION, SPONTANEOUS; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; ASPIRIN; FEMALE; HEPARIN; HUMANS; PLACENTA; PREDNISONE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY, HIGH-RISK; THROMBOSIS; TROPHOBLASTS;

EID: 0032974267     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/5.3.267     Document Type: Review

References (100)

1. Alarcon-Segovia, D. and Sanchez-Guerrero, J. (1989) Primary antiphospholipid syndrome. J. Rheumatol., 16, 482-489.
2. Andree, H.A.M., Hermans, W.T., Hemker, H.C. et al. (1992) Displacement of factor Va by annexin V. In Andree, H.A.M. (ed.), Phospholipid Binding and Anticoagulant Action of Annexin V. Universitaire Pers Maastricht, Maastricht, The Netherlands, pp. 73-85.
3. Aoki, K., Dudkiewicz, A.B., Matsuura, E. et al. (1995) Clinical significance of β2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: correlation with conventional antiphospholipid antibody detection systems. Am. J. Obstet. Gynecol., 172, 926-931.
4. Arvieux, J., Roussel, B., Jacob, M.C. et al. (1991) Measurement of antiphospholipid antibodies by Elisa using β2-Glycoprotein I as an antigen. J. Immunol. Methods, 143, 223-230.
5. Balash, J., Carmona, F., Lopez-Soto, A. et al. (1993) Low-dose aspirin for prevention of pregnancy losses in women with primary antiphospholipid syndrome. Hum. Reprod., 8, 2234-2239.
6. Balash, J., Creus, M., Fabregues, F. et al. (1996) Antiphospholipid antibodies and human reproductive failure. Hum. Reprod., 11, 2310-2315.
7. Benifla, J.L., Tchobroutsky, C., Uzan, M. et al. (1992) Predictive value of uterine artery velocity waveforms in pregnancies complicated by systemic lupus erythematosus and the antiphospholipid syndrome. Fetal Diag. Ther., 7, 195-202.
8. Bertina, R.M., Koeleman, B.P.C., Koster, F. et al. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 64-67.
9. Birdsall, M.A., Lockwood, G.M., Ledger, W.L. et al. (1996) Antiphospholipid antibodies in women having in-vitro fertilization. Hum. Reprod., 11, 1185-1189.
10. Blank, M., Cohen, J., Toder, V. et al. (1991) Induction of antiphospholipid syndrome by positive transfer of anticardiolipin antibodies. Proc. Natl Acad. Sci. USA, 88, 3069-3073.
11. Blank, M., Faden, D. and Tincani, A. (1994) Immunization with anticardiolipin cofactor (β2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J. Autoimmun., 7, 441-455.
12. Blank, M., George, J., Fishman, P. et al. (1998) Ciprofloxacin immunomodulation of experimental antiphospholipid syndrome associated with elevation of interleukin-3 and granulocyte-macrophage colony-stimulating factor expression. Arthritis Rheum., 41, 224-232.
13. Bokarewa, M.I., Bremme, K., Falk, G. et al. (1995) Studies on phospholipid antibodies, APC resistance and associated mutation in the coagulation factor V gene. Thromb. Res., 78, 193-200.
14. Bokarewa, M.I., Wramsby, M. and Bremme, K. (1998) Reactivity against antiphospholipids during pregnancy. Hum. Reprod., 13, 2633-2635.
15. Bowie, W.E.J., Thompson, J.H., Pascuzzi, C.A. et al. (1963) Thrombosis in Systemic Lupus Erythematosus despite circulating anticoagulants. J. Clin. Invest., 62, 416-430.
16. Branch, D.W., Scott, J.R., Kochenour, N.K. et al. (1985) Obstetrics complications associated with the lupus anticoagulant. N. Engl. J. Med., 313, 1322-1326.
17. Branch, D.W., Dudley, D.J., Mitchell, M.D. et al. (1990) Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in Balb/c mice: a model for autoimmune fetal loss. Am. J. Obstet. Gynecol., 163, 210-216.
18. Bronson, R. (1995) Immunology and reproductive medicine. Hum. Reprod., 10, 755-757.
19. Canoso, R.T. and de Oliveira, R.M. (1988) Chlorpromazine-induced anticardiolipin antibodies and lupus anticoagulant: absence of thrombosis. Am. J. Hematol., 27, 272-275.
20. Carreras, L.O., Defreyn, G., Machin, S.J. et al (1981) Recurrent arterial thrombosis, repeated intrauterine death and 'lupus' anticoagulant: detection of immunoglobulin interfering with prostacyclin formation. Lancet, i, 244-246.
21. Caruso, A., De Carolis, S., Ferrazzani, S. et al. (1993) Pregnancy outcome in relation to uterine artery flow velocity waveforms and clinical characteristics in women with antiphospholipid syndrome. Obstet. Gynecol., 82, 970-977.
22. Caruso, A., De Carolis, S., Ferrazzani, S. et al. (1997) Antiphospholipid antibodies in pregnant patients. Int. J. Immun. Pharmacol., 10, 137-138.
23. Chamley, L.W., Duncalf, A.M., Mitchell, M.D. et al. (1998) Action of anticardiolipin and antibodies to β2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death. Lancet, 352, 1037-1038.
24. Christiansen, O.B., Ulcova-Gallova, Z., Mohapeloa, H. and Krauz, V. (1998) Studies on associations between human leukocyte antigen (HLA) class II alleles and antiphospholipid antibodies in Danish and Czech women with recurrent miscarriages. Hum. Reprod., 13, 3326-3331.
25. Cowchock, S. (1996) Prevention of fetal death in the antiphospholipid antibody syndrome. Lupus, 5, 467-472.
26. Cowchock, S., Reece, E.A., Balaban, D. et al. (1992) Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am. J. Obstet. Gynecol., 166, 1318-1324.
27. Dale, M.P. and Robinson, N.C. (1988) Synthesis of cardiolipin derivatives with protection of the free hydroxyl: its application to the study of cardiolipin stimulation of cytochrome C oxidase. Biochemistry, 27, 8270-8275.
28. Del Papa, N., Guidali, L., Sala, A. et al. (1997) Endothelial cells as a target for antiphospholipid antibodies. Arthritis Rheum., 40, 551-561.
29. Di Simone, N., De Carolis, S., Lanzone, A. et al. (1995) In vitro effect of antiphospholipid antibody-containing sera on basal and gonadotrophin releasing hormone-dependent human chorionic gonadotrophin release by cultured trophoblast cells. Placenta, 16, 75-83.
30. Di Simone, N., Ferrazzani, S., Castellani, R. et al. (1997) Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody containing sera. Hum. Reprod., 12, 2061-2065.
31. Di Simone, N., Caliandro, D., Castellani, R. et al. (1999) Low-molecular weight heparin restores in vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G from patients with antiphospholipid syndrome. Hum. Reprod. 14, 489-495.
32. Drakeley, A.J., Quenby, S. and Farquharson, R.G. (1998) Mid-trimester loss-appraisal of a screening protocol. Hum. Reprod., 13, 1975-1980.
33. Elias, M. and Eldor, A. (1984) Thromboembolism in patients with the lupus-type circulating anticoagulant. Arch. Intern Med., 144, 510-515.
34. El-Roeiy, A., Myers, S.A. and Gleicher, N. (1991) The relationship between autoantibodies and intrauterine growth retardation in hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol., 164, 1253-1261.
35. Emlen, W. (1996) Antiphospholipid antibodies: new complexity and new assays. Arthritis Rheum., 39, 1441-1443.
36. Fadok, V.A., Voelker, D.R., Campbell, P.A. et al. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol., 148, 2207-2216.
37. Fishman, P., Falach-Vaknin, E., Zigelman, R. et al. (1993) Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3. J. Clin. Invest., 91, 1834-1837.
38. Fishman, P., Falach-Vaknin, E., Sredni, B. et al. (1996) Aspirin-interleukin-3 interrelationships in patients with antiphospholipid syndrome. Am. J. Reprod. Immunol., 35, 80-84.
39. Foraouzan, I., Cohen, A.W., Lindenbaum, C. et al. (1993) Umbilical artery and ductal blood flow velocities in patients treated with aspirin and prednisone for presence of anticardiolipin antibody. J. Ultrasound Med., 12, 135-138.
40. Francis, R.B., McGhee, W.G. and Feinstein, D.I. (1988) Endothelial dependent fibrinolysis in subjects with the lupus anticoagulant and thrombosis. Thromb. Haemost, 39, 412-414.
41. Garcia, C.O., Kanbour-Shakir, A., Tang H. et al. (1997) Induction of experimental antiphospholipid antibody syndrome in PL/J mice following immunization with β2GP-I. Am. J. Reprod. Immunol., 37, 118-121.
42. George, J., Blank, M., Levy, Y. et al. (1998) Differential effects of anti-β2-glycoprotein-I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome. Circulation, 97, 900-906.
43. Geva, E., Yaron, Y., Lessing, J.B. et al. (1994) Circulating autoimmune antibodies may be responsible for implantation failure in in vitro fertilization. Fertil. Steril., 62, 802-806.
44. Gharavi, A.E., Sammaritano, L.R., Wen, J. et al. (1992) Induction of antiphospholipid antibodies by immunization with β2-glycoprotein I (apolipoprotein H). J. Clin. Invest., 90, 1105-1109.
45. Gleicher, N. (1997) Antiphospholipid antibodies and reproductive failure: what they do and what they do not do; how to, and how not to treat! Hum. Reprod., 12, 13-16.
46. Gleicher, N., Harlow, L. and Zilberstein, M. (1992) Regulatory effect of antiphospholipid antibodies on signal transduction: a possible model for auto-antibodies-induced reproductive failure. Am. J. Obstet. Gynecol., 167, 637-642.
47. Gleicher, N., Pratt, D. and Dudkiewicz, A. (1993) What do we really know about autoantibody abnormalities and reproductive failure: a critical review. Autoimmunity, 16, 115-140.
48. Gleicher, N., Liu, H., Dudkiewicz, A. et al. (1994) Autoantibodies profiles and immunoglobulin levels as predictors of in vitro fertilization success. Am. J. Obstet. Gynecol., 170, 1145-1149.
49. Habib, A., Martinuzzo, M., Lebret, M. et al. (1993) Lupus anticoagulant IgGs do not depend on serum for the induction of cyclooxygenase-2 by human endothelial cells. In Samuelson, B., Paoletti, R., Granstrom, E., Ramwell, P.W., Folco, G. and Nicosia, S. (eds), Advances in Prostaglandin, Thromboxane and Leukotriene Research. Raven Press, New York.
50. Hasegawa, I., Takakuwa, K., Goto, S. et al. (1992) Effectiveness of prednisolone/aspirin therapy for recurrent aborters with antiphospholipid antibodies. Hum. Reprod., 7, 203-207.
51. Hojnik, M., Gilburd, B., Ziporen, L. et al. (1994) Anticardiolipin antibodies in infections are heterogeneous in their dependency on β2-glycoprotein I: analysis of anticardiolipin antibodies in leprosy. Lupus, 3, 515-521.
52. Hughes, G.R.V., Harris, E.N. and Gharavi, A.E. (1986) The anticardiolipin syndrome. J. Rheumatol., 13, 486-489.
53. Hunt, J. and Krillis, S. (1994) The fifth domain of β2-glycoprotein I contains a phospholipid binding site (C45 281-C45 288) and a region recognized by anticardiolipin antibodies. J. Immunol., 152, 653-659.
54. Ikematsu, W., Luan, F.L., La Rosa, L. et al. (1998) Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice. Arthritis Rheum., 41, 1026-1039.
55. Kaaja, R., Julkunen, H., Viinikka, L. and Ylikorkala, O. (1993) Production of prostacyclin and thromboxane in lupus pregnancies: effect of small dose of aspirin. Obstet. Gynecol., 81, 327-331.
56. Katsuragawa, H., Kanzaki, H., Inove, T. et al. (1997)Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol. Reprod., 56, 50-58.
57. Koopman, G., Reutelingsperger, C.P., Kuijten, G.A. et al. (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood, 84, 1415-1420.
58. Korneberg, A., Blank, M., Kaufman, S. et al. (1994) Induction of tissue factor-like activity in monocytes by anticardiolipin antibodies. J. Immunol., 153, 1328-1331.
59. Krikun, G., Lockwood, C.J., Wu, X.X. et al. (1994) The expression of the placental anticoagulant protein, annexin V, by villous trophoblast: immunolocalization and in vitro regulation. Placenta, 15, 601-612.
60. Kutteh, W.H. (1996) Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am. J. Obstet. Gynecol., 174, 1584-1589.
61. La Rosa, L., Meroni, P.L., Tincani, A. et al. (1994) β2-glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome. J. Rheumatol., 21, 1684-1693.
62. Laskin, C.A., Bombardier, C., Hannah, M.E. et al. (1997) Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N. Engl. J. Med., 337, 148-153.
63. Lellouche, F., Martinuzzo, M., Said, P. et al. (1991) Imbalance of thromboxane/prostacyclin biosynthesis in patients with lupus anticoagulant. Blood, 78, 2894-2899.
64. Levin, M., Eley, B.S., Louis, J. et al. (1995) Postinfectious purpura fulminans caused by an autoantibody directed against protein S. J. Pediatr., 127, 355-363.
65. Lima, F., Khamashta, M.A., Buchanan, N.M. et al. (1996) A study of sixty pregnancies in patients with the antiphospholipid syndrome. Clin. Exp. Rheumatol., 14, 131-136.
66. Lockood, C.J. and Rand, J.H. (1994) The immunobiology and obstetrical consequences of antiphospholipid antibodies. Obstet. Gynecol. Surv., 49, 432-441.
67. Lubbe, W.F., Buther, W.S., Palmer, S.J. et al. (1983) Fetal survival after prednisone suppression of maternal lupus-anticoagulant. Lancet, i, 1361-1363.
68. Lyden, T.W., Vogt, E., Ng, A.K. et al. (1992) Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. J. Reprod. Immunol., 22, 1-14.
69. Maier, D.B. and Parke, A. (1989) Subclinical autoimmunity in recurrent aborters. Fertil. Steril., 51, 280-285.
70. Manco-Johnson, M.J., Nuss, R., Key, N. et al. (1996) Lupus anticoagulant and protein S deficiency in children with post-varicella purpura fulminans or thrombosis. J. Pediatr., 128, 319-323.
71. Martinuzzo, M.E., Forastiero, R.R. and Carreras, L.O. (1995) Anti-β2-glycoprotein-I antibodies: detection and association with thrombosis. Br. J. Haematol., 89, 397-402.
72. Matsuura, E., Igarashi, Y., Fujimoto, M. et al. (1990) Anticardiolipin cofactor(d) and differential diagnosis of autoimmune disease. Lancet, 336, 177-178.
73. McIntyre, J.A. (1992) Immune recognition at the maternal-fetal interface: overview. Am. J. Reprod. Immunol., 28, 127-131.
74. McIntyre, J.A., Taylor, C.G., Torry, D.S. et al. (1993) Heparin and pregnancy in women with a history of repeated miscarriages. Haemostasis, 23, 202-211.
75. McNally, T., Makie, I.J., Machin, S.J. et al. (1995) Increased levels of β2-glycoprotein I antigen and β2-glycoprotein I/binding antibodies are associated with a history of thromboembolic complications in patients with SLE and primary antiphospholipid syndrome. Br. J. Rheumatol., 34, 1031-1036.
76. McNeil, H.P., Chesterman, C.N. and Krilis, S.A. (1991) Immunology and clinical importance of antiphospholipid antibodies. Adv. Immunol., 49, 193-289.
77. Meizner, I., Katz, M. and Press, F. (1988) Assessment of utero-placental blood flow velocity waveforms in a pregnant patient with systemic lupus erythematosus. J. Clin. Ultrasound, 6, 55-57.
78. Nurat, P., Oliveness, F., de Muzon, J. et al. (1994) Task force report on the outcome of pregnancies and children conceived by in vitro fertilization. Fertil. Steril., 61, 324-330.
79. Oliveness, F., Kadhel, P., Rufat, P. et al. (1996) Perinatal outcome of twin pregnancies obtained after in vitro fertilization: comparison with twin pregnancies obtained spontaneously after ovarian stimulation. Fertil. Steril., 66, 105-109.
80. Oosting, J.D., Derksen, R.H., Bobbink, I.W. et al. (1993) Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C or protein S: an explanation for their pathogenic mechanism? Blood, 81, 2618-2625.
81. Op den Kamp, J.A.F. (1979) Lipid asymmetry in membranes. Annu. Rev. Biochem., 48, 41-71.
82. Peaceman, A.M. and Rehnenberg, K.A. (1993) The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production. Am. J. Obstet. Gynecol., 169, 1403-1406.
83. Pierangeli, S.S., Harris, E.N., Davis, S.A. et al. (1992) β2-glycoprotein-I enhances cardiolipin binding activity but is not the antigen for antiphospholipid antibodies. Br. J. Haematol., 82, 565-570.
84. Rai, R.S., Clifford, K., Cohen, H. et al. (1995) High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum. Reprod., 10, 3301-3304.
85. Rai, R., Cohen, H., Dave, M. et al. (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). Br. Med. J., 314, 253-257.
86. Rand, J.H., Wu, X., Andree, H.A.M. et al. (1997) Pregnancy loss in the antiphospholipid-antibody syndrome. A possible thrombogenic mechanism. N. Engl. J. Med., 337, 154-160.
87. Rote, N.S., Chang, J., Katsuragawa, H. et al. (1995) Expression of phosphatidylserine-dependent antigens on the surface of differentiating BeWo human chorioncarcinoma cells. Am. J. Reprod. Immunol., 33, 114-121.
88. Rote, N.S., Vogt, E., De Vere, G. et al. (1998) The role of placental trophoblast in the pathophysiology of the antiphospholipid antibody syndrome. Am. J. Reprod. Immunol., 39, 125-136.
89. Roubey, R.A. (1994) Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other phospholipid antibodies. Blood, 89, 2854-2867.
90. Rubbert, A., Bock, E., Schwab, J. et al. (1994) Anticardiolipin antibodies in HIV infection: association with cerebral perfusion defects as detected by 99mTc-HMPAO SPECT. Clin. Exp. Immunol., 98, 361-368.
91. Sammaritano, L.R., Gharavi, A.E., Soberano, C. et al. (1992) Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein. J. Clin. Immunol., 12, 27-35.
92. Schick, P.K., Kurica, K.B., Chacko, G.K. et al. (1976) Localization of phosphatidylethanolamine and phosphatidylserine in the human platelet plasma membrane. J. Clin. Invest., 57, 1221-1226.
93. Schousboe, I. (1985) β2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood, 66, 1086-1091.
94. Shoenfeld, Y. and Blank, M. (1994) Effect of long-acting thromboxane receptor antagonist (BMS 180/291) on experimental antiphospholipid syndrome. Lupus, 74, 770-777.
95. Tulppala, M., Marttunen, M., Soderstrom, V. et al. (1997) Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum. Reprod., 12, 1567-1572.
96. Unander, A.M., Norberg, R., Hahn, L. and Arfors, L. (1987) Anticardiolipin antibodies and complement in ninety-nine women with habitual abortion. Am. J. Obstet. Gynecol., 156, 114-119.
97. Vila, P., Hernandez, M.C., Lopez-Fernandez, M.F. et al. (1994) Prevalence, follow-up and clinical significance of the anticardiolipin antibodies in normal subjects. Thromb. Haemost., 72, 209-213.
98. Vogt, E., Ng, A.K., Role, N.S. et al. (1996) A model for antiphospholipid antibody syndrome: monoclonal antiphosphatidylserine antibody induces intrauterine growth restriction in mice. Am. J. Obstet. Gynecol., 174, 700-708.
99. Yamazaki, M., Asakura, H., Kawamura, Y. et al. (1991) Transient lupus anticoagulant induced by Epstein-Barr virus infection. Blood Coag. Fibrinol., 2, 771-774.
100. Zarrabi, M.H., Zucker, S., Miller, F. et al. (1979) Immunologic and coagulation disorders in chlorpromazine-treated patients. Ann. Intern. Med., 91, 194-199.