Internalization of the 180 kDa bullous pemphigoid antigen as immune complexes in basal keratinocytes: An important early event in blister formation in bullous pemphigoid

British Journal of Dermatology

Volumn 138, Issue 1, 1998, Pages 71-76

  Kitajima, Y ^a   Nojiri, M ^a   Yamada, T ^a   Hirako, Y ^b   Owaribe, K ^b  

^a GIFU UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; BASAL CELL; BULLOUS SKIN DISEASE; FEMALE; HUMAN; HUMAN TISSUE; INTERNALIZATION; KERATINOCYTE; MALE; PATHOPHYSIOLOGY; PEMPHIGOID; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ANTIGEN-ANTIBODY COMPLEX; AUTOANTIGENS; CARRIER PROTEINS; COLLAGEN; CYTOSKELETAL PROTEINS; EPIDERMIS; FEMALE; HUMANS; IMMUNOGLOBULIN G; KERATINOCYTES; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NERVE TISSUE PROTEINS; NON-FIBRILLAR COLLAGENS; PEMPHIGOID, BULLOUS; TIME FACTORS;

EID: 0031934498     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1998.02028.x     Document Type: Article

References (25)

1. Stanley JR, Hawley-Nelson P, Yuspa SH et al. Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified epithelia. Cell 1981; 24: 897-903.
2. Jordon RE, Kawana S, Fritz KA. Immunopathologic mechanisms in pemphigus and bullous pemphigoid. J Invest Dermatol 1985; 85 (Suppl. 72): 8.
3. Labib RS, Anhalt GJ, Patel HP et al. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 1986; 136: 1231-5.
4. Meyer LJ, Taylor TB, Kadunce DP, Zone JJ. Two groups of bullous pemphigoid antigens are identified by affinity-purified antibodies. J Invest Dermatol 1990; 94: 611-16.
5. Stanley JR, Tanaka T, Mueller S et al. Isolation of complementary DNA for bullous pemphigoid antigen by use of patient's autoantibodies. J Clin Invest 1988; 82: 1864-70.
6. Tanaka T, Korman NJ, Shimizu H et al. Production of rabbit antibodies against carboxy-terminal epitopes encoded by bullous pemphigoid cDNA. J Invest Dermatol 1990; 94: 617-23.
7. Amagai M, Hashimoto T, Tajima S et al. Partial cDNA cloning of the 230-kD mouse bullous pemphigoid antigen by use of a human monoclonal antibasement membrane zone antibody. J Invest Dermatol 1990; 95: 252-9.
8. Sawamura D, Li K, Chu M-L, Uitto J. Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains. J Biol Chem 1991; 266: 17784-90.
9. Green KJ, Virata ML, Elgart GW et al. Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: Members of a new gene family involved in organization of intermediate filaments. Int Biol Macromol 1992; 14: 145-53.
10. Diaz LA, Ratire H III, Saunders W et al. Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. J Clin Invest 1990; 86: 1088-94.
11. Giudice GJ, Emery DJ, Diaz LA. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 1992; 99: 243-50.
12. Liu Z, Diaz LA, Troy JL et al. A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest 1993; 92: 2480-8.
13. Giudice GJ, Emery DJ, Zelickson BD et al. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol 1993; 151: 5742-50.
14. Giudice GJ, Wilske KC, Anhalt GJ et al. Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis. J Invest Dermatol 1994; 102: 878-81.
15. Matsumura K, Amagai M, Nishikawa T, Hashimoto T. Majority of bullous pemphigoid and herpes gestation is sera react with NC16a domain of the 180kD bullous pemphigoid antigen. Arch Dermatol Res 1996; 288: 507-9.
16. Kitajima Y, Hirako Y, Owaribe K, Yaoita H. A possible cell-biologic mechanism involved in blister formation of bullous pemphigoid: anti-180-kD BPA antibody is an initiator. Dermatology 1994; 189 (Suppl. 1): 46-9.
17. Kitajima Y, Hirako Y, Owaribe K et al. Antibody-binding to the 180-kD bullous pemphigoid antigens at the lateral cell surface causes their internalization and inhibits their assembly at the basal cell surface in cultured keratinocytes. J Dermatol 1994; 21: 838-46.
18. Nishizawa Y, Hematsu J, Owaribe K. HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesmosome. J Biochem 1993; 113: 493-501.
19. Owaribe K, Nishizawa Y, Franke WW. Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells. Exp Cell Res 1991; 19: 2622-30.
20. Kitajima Y, Owaribe K, Hirako Y et al. Regulation of hemidesmosomes: the mechanisms for the assembly of the 230-kD and 180-kD bullous pemphigoid antigens at dermal-epidermal junctions. In: Electron Microscopy in Dermatology-Basic and Clinical Research. Ishibashi Y, Nakagawa H, Suzuki H. eds Amsterdam: Elsevier Science BV; 1994: 111-20.
21. Kitajima Y, Owaribe K, Nishizawa Y et al. Phorbol ester- and calcium-induced reorganization 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy. Exp Cell Res 1992; 203: 17-24.
22. Liu Z, Giudice GJ, Swartz SJ et al. The role of complement in experimental bullous pemphigoid. J Clin Invest 1995; 95: 1539-44.
23. Liu Z, Twining S, Guidice GJ et al. Neutrophil elastase is essential for subepidermal blistering in experimental bullous pemphigoid (abstract). J Invest Dermatol 1997; 108: 556.
24. Korman NJ. In situ-bound antibodies eluted from the skin of patients with bullous pemphigoid are preferentially directed against the 230-kD bullous pemphigoid antigen. J Invest Dermatol 1995; 105: 824-30.
25. Stanley JR. A specific antigen-antibody interaction triggers the cellular pathophysiology of bullous pemphigoid. Br J Dermatol 1985; 113 (Suppl. 28): 67-73.