Signals involved in the early TH1/TH2 polarization of an immune response depending on the type of antigen

Journal of Allergy and Clinical Immunology

Volumn 103, Issue 2 II, 1999, Pages 298-306

  Bellinghausen, Iris ^a   Brand, Udo ^a   Enk, Alexander H ^a   Knop, Jürgen ^a   Saloga, Joachim ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cytokines; Epidermal cells; Hapten; IL 10; Protein allergen

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HELPER CELL; IMMUNOGENICITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ALLERGENS; ANIMALS; BLOTTING, SOUTHERN; CELL POLARITY; CELLS, CULTURED; CYTOKINES; DINITROCHLOROBENZENE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FEMALE; HAPTENS; IMMUNOGLOBULINS; INTERLEUKIN-10; KINETICS; LYMPH NODES; MICE; MICE, INBRED BALB C; OVALBUMIN; PICRYL CHLORIDE; POLLEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN; TH1 CELLS; TH2 CELLS;

EID: 0032972279     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(99)70505-1     Document Type: Article

References (39)

1. Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci U S A 1992;89:1398-402.
2. Enk AH, Katz SI. Contact sensitivity as a model for T-cell activation in skin. J Invest Dermatol 1995;105:80S-3S.
3. Bellinghausen I, Enk AH, Mohamadzadeh M, Lohmann S, Knop J, Saloga J. Epidermal cells enhance interleukin 4 and immunoglobulin E production after stimulation with protein allergen. J Invest Dermatol 1996;107:582-8.
4. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
5. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
6. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-93.
7. Finkelman ED, Katona IM, Urban JF Jr, Holmes J, Ohara J, Tung AS, et al. IL-4 is required to generate and sustain in vivo IgE responses. J Immunol 1988;141:2335-41.
8. Nakamura T, Lee RK, Nam SY, Podack ER, Bottomly K, Flavell RA. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol 1997;158:2648-53.
9. Trinchieri G. Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 1993;14:335-8.
10. Seder RA, Gazzinelli R, Sher A, Paul WE. IL-12 acts directly on CD4+ T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc Natl Acad Sci U S A 1993;90:10188-92.
11. Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 1996;26:659-68.
12. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugiu FS, et al. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142-7.
13. Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994;76:241-51.
14. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 1995;378:88-91.
15. Micallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, et al. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur J Immunol 1996;26:1647-51.
16. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991;146:3444-51.
17. D'Andrea A, Aste Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-8.
18. Hosken NA, Shibuya K, Heath AW, Murphy KM, O'Garra A. The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-α β-transgenic model. J Exp Med 1995;182:1579-84.
19. DeKruyff RH, Fang Y, Umetsu DT. IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type. J Immunol 1992;149:3468-76.
20. Catalina MD, Carroll MC, Arizpe H, Takashima A, Estess P, Siegelman MH. The route of antigen entry determines the requirement for L-selectin during immune responses. J Exp Med 1996;184:2341-51.
21. Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997;15:297-322.
22. Saloga J, Renz H, Larsen GL, Gelfand EW. Increased airways responsiveness in mice depends on local challenge with antigen. Am J Respir Crit Care Med 1994;149:65-70.
23. Umetsu DT, DeKruyff RH. Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases. Proc Soc Exp Biol Med 1997;215:11-20.
24. Kapsenberg ML, Wierenga EA, Stiekema FEM, Tiggelman AMBC, Bos JD. Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and non-allergic individuals. J Invest Dermatol 1992;98:59-63.
25. Fong TA, Mosmann TR. The role of IFN-γ in delayed-type hypersensitivity mediated by Th1 clones. J Immunol 1989;143:2887-93.
26. Robinson DS, Hamid Q, Jacobson M, Ying S, Kay AB, Durham SR. Evidence for Th2-type T helper cell control of allergic disease in vivo. Springer Semin Immunopathol 1993;15:17-27.
27. van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML. High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 1991;97:389-94.
28. Wang LF, Lin JY, Hsieh KH, Lin RH. Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J Immunol 1996;156:4079-82.
29. Metcalfe DD. Food allergens. Clin Rev Allergy 1985;3:331-49.
30. Hsieh CS, Heimberger AB, Gold JS, O'Garra A, Murphy KM. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an Ab T-cell receptor transgenic system. Proc Natl Acad Sci U S A 1992;89:6065-9.
31. Marth T, Strober W, Kelsall BL. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J Immunol 1996;157:2348-57.
32. Enk AH, Katz SI. Identification and induction of keratinocyte-derived IL-10. J Immunol 1992;149:92-5.
33. Enk AH, Angeloni VL, Udey MC, Katz SI. Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 1993;151:2390-8.
34. Enk AH, Saloga J, Becker D, Mohamadzadeh M, Knop J. Induction of hapten-specific tolerance by interleukin 10 in vivo. J Exp Med 1994;179:1397-402.
35. Kühn U, Brand P, Willemsen J, Jonuleit H, Enk AH, van Brandwijk-Petershans R, et al. Induction of tyrosine phosphorylation in human MHC class II-positive antigen-presenting cells by stimulation with contact sensitizers. J Immunol 1998;160:667-73.
36. Enk AH, Angeloni VL, Udey MC, Katz SI. An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin. J Immunol 1993;150:3698-704.
37. Müller G, Saloga J, Germann T, Schuler G, Knop J, Enk AH. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. J Immunol 1995;155:4661-8.
38. Stoll S, Muller G, Kurimoto M, Saloga J, Tanimoto T, Yamauchi H, et al. Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes. J Immunol 1997;159:298-302.
39. Xu H, Dilulio NA, Fairchild RL. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon γ-producing (Tcl) effector CD8+ T cells and interleukin (II) 4/I1-10-producing (Th2) negative regulatory CD4+ T cells. J Exp Med 1996;183:1001-12.