Epidermal cells enhance interleukin 4 and immunoglobulin E production after stimulation with protein allergen

Journal of Investigative Dermatology

Volumn 107, Issue 4, 1996, Pages 582-588

  Bellinghausen, Iris ^a   Enk, Alexander H ^a   Mohamadzadeh, Mansour ^a   Lohmann, Sabine ^a   Knop, Jürgen ^a   Saloga, Joachim ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cytokines; Epidermis; IL 10; Ovalbumin

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029818706     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12582825     Document Type: Article

References (33)

1. Aebischer I, Stämpfli MR, Zürcher A, Miescher S, Urwyler A, Frey B, Luger T, White RR, Stadler BM: Neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis. Eur J Immunol 24:1908-1913, 1994
2. Benner R, Savelkoul HF: Regulation of IgE production in mice. Eur Respir J Suppl 13:97s-104s, 1991
3. Bieber T, Dannenberg B, Prinz JC, Rieber EP, Stolz W, Braun-Falco O, Ring J: Occurrence of IgE-bearing epidermal Langerhans cells in atopic eczema: a study of the time course of the lesions and with regard to the IgE serum level. J Invest Dermatol 93:215-219, 1989
4. Bruijnzeel Koomen CA, van Wichen DF, Toonstra J, Berrens L, Bruijnzeel PL: The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 278:199-205, 1986
5. Brunda MJ: Interleukin-12. J Leukocyte Biol 55:280-288, 1994
6. Del Prete G: Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy 47:450-455, 1992
7. Del Prete GF, De Carli M, Ricci M, Romagnani S: Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. J Exp Med 174:809-813, 1991
8. Enk AH, Angeloni VL, Udey MC, Katz SI: Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 151:2390-2398, 1993
9. Enk AH, Katz SI: Identification and induction of keratinocyte-derived IL-10. J Immunol 149:92-95, 1992a
10. Enk AH, Katz SI: Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 89:1398-1402, 1992b
11. Finkelman FD, Holmes J, Katona IM, Urban JF Jr, Beckmann MP, Park LS, Schooley KA, Coffman RL, Mosmann TR, Paul WE: Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8:303-333, 1990
12. Finkelman FD, Urban JF Jr, Beckmann MP, Schooley KA, Holmes JM, Katona IM: Regulation of murine in vivo IgG and IgE responses by a monoclonal anti-IL-4 receptor antibody. Int Immunol 3:599-607, 1991
13. Hauser C, Snapper CM, Ohara J, Paul WE, Katz SI: T Helper cells grown with hapten-modified cultured Langerhans' cells produce interleukin 4 and stimulate IgE production by B cells. Eur J Immunol 19:245-251, 1989
14. Inaba K, Inaba N, Romani N, Aya H, Deguchi M, Ikehara S, Matsumura S, Steinman RM: Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulozyte/macrophage colony-stimulating factor. J Exp Med 176:1693-1702, 1992
15. Kripke ML, Munn CG, Jeevan A, Tang JM, Bucana C: Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J Immunol 145:2833-2838, 1990
16. McMenamin C, Holt PG: The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated hut MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178:889-899, 1993
17. McMenamin C, Schon Hegrad M, Oliver J, Girn B, Holt PG: Regulation of IgE responses to inhaled antigens: cellular mechanisms underlying allergic sensitization versus tolerance induction. Int Arch Allergy Appl Immunol 94:78-82, 1991
18. Modlin RL: Th1-Th2 paradigm: insights from leprosy. J Invest Dermatol 102:828-832, 1994
19. Mohamadzadeh M, Lipkow T, Kolde G, Knop J: Expression of an epitope as detected by the novel monoclonal antibody 4F7 on dermal and epidermal dendritic cells. I. Identification and characterization of the 4F7+ dendritic cell in situ. J Invest Dermatol 101:832-838, 1993
20. Morris SC, Madden KB, Adamovicz JJ, Gause WC, Hubbard BR, Gately MK, Finkelman FD: Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 152:1047-1056, 1994
21. Mudde GC, van Reijsen FC, Bruijnzeel Koomen CA: IgE-positive Langerhans cells and Th2 allergen-specific T cells in a topic dermatitis. J Invest Dermatol 99:103S, 1992
22. Muller KM, Jaunin F, Masouye I, Saurat JH, Hauser C: TH2 cells mediate IL-4-dependent local tissue inflammation. J Immunol 150:5576-5584, 1993
23. Ohmen J, Hanifin J, Nickoloff B, Rea TH, Wyzykowski R, Kim J, Jullien D, McHugh T, Nassif AS, Chan SC, Modlin RL: Overexpression of IL-10 in atopic dermatitis. J Immunol 154:1956-1963, 1995
24. Picker LJ: Control of lymphocyte homing. Curr Opin Immunol 6:394-406, 1994
25. Picker LJ, Treer JR, Ferguson Darnell B, Collins PA, Bergstresser PR, Terstappen LW: Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 150:1122-1136, 1993
26. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW: Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J Allergy Clin Immunol 89:1127-1138, 1992
27. Komagnani S: Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 98:279-285, 1992
28. Sager N, Feldmann A, Schilling G, Kreitsch P, Neumann C: House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 89:801-810, 1992
29. Saloga J, Renz H, Larsen GL, Gelfand EW: Increased airways responsiveness in mice depends on local challenge with antigen. Am J Respir Crit Care Med 149:65-70, 1994
30. van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML: High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 97:389-394, 1991
31. Vercelli D: Regulation of IgE synthesis. Allergy Proc 14:413-416, 1993
32. Vercelli D, Geha RS: Regulation of IgE synthesis in humans. J Clin Immunol 9:75-83, 1989
33. Vercelli D, Jabara HH, Arai K, Geha RS: Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med 169:1295-1307, 1989