Double biochemical modulation of 5-fluorouracil by methotrexate and folinic acid for the treatment of advanced colorectal cancer

Clinical Drug Investigation

Volumn 17, Issue 2, 1999, Pages 83-88

  Polyzos, Aristidis ^a,b   Tsavaris, N ^a   Kosmas, C ^a   Petrikos, G ^a   Stamatiadis, D ^a   Kalahanis, N ^a   Giannopoulos, A ^a   Karatzas, G ^a   Sfikakis, P P ^a  

^a LAIKO GENERAL HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; METHOTREXATE;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANOREXIA; ARTICLE; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; COLORECTAL CANCER; DIARRHEA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HUMAN; HYPERPIGMENTATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RASH; THROMBOCYTOPENIA;

EID: 0032971994     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199917020-00001     Document Type: Article

References (21)

1. 1. Houghton A, Maroda SJ, Philips JO, et al. Biochemical determinants of responsiveness to 5 fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice. Cancer Res 1981; 41: 144-9
2. 2. Poon MA, O'Connell MJ, Moertel CG, et al. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989; 7: 1407-18
3. 3. Einhorn LH. Improvements in fluorouracil chemotherapy? J Clin Oncol 1989; 10: 1377-9
4. 4. Cadman E, Heimer R, Lavis L. Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism. Science 1979; 205: 1135-7
5. 5. Benz C, Cadman E. Modulation of 5-fluorouracil metabolism and cytotocixity by antimetabolite pretreatment in human colorectal adenocarcinoma I-ICT-8. Cancer Res 1981; 41: 994-9
6. 6. Advanced Colorectal Cancer Metaanalysis Project Metaanalysis of randomised trials testing the biochemical modulation of 5-fluorouracil by methotrexate in metastatic colorectal cancer. J Clin Oncol 1994; 12: 960-9
7. 7. Abad A Rosell R. Pastor MC, et al. Sequential combination of methotrexate (MTX) 5-fluorouracil (FU) and high dose folinic acid (FA) in advanced colorectal cander: double bio chemical modulation? Am J Clin Oncol 1991; 14: 393-6
8. 8. Polyzos A, Tsavaris N, Giannopoulos A, et al. Biochemical modulation of fluorouracil: comparison of methotrexate, folinic acid and fluorouracil versus folinic acid and fluorouracil in advanced colorectal cancer, a randomized trial. Cancer Chemother Pharmacol 1996; 38: 292-7
9. 9. Romero A, Perez J, Cuevas M, et al. Double modulation of 5 fluorouracil by methotrexate and high dose L-Leucovorin in advanced colorectal cancer [abstract]. Proc Am Soc Clin Oncol 1995; 14: 209
10. 10. Comella P, Palmieri G, Lorusso V, et al. Double biochemical modulation of 5. fluorouracil by methotrexate and Levofolinic acid in the treatment of advanced digestive tract malignancies. Eur J Cancer 1996; 32M 10: 1719-26
11. 11. Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer 1981; 47: 207-14
12. 12. Gralla R. Approaches to management of emesis. Clinician 1988; 6: 26-39
13. 13. Kaplan EL, Meier P. Nonparametric estimation for incomplete observations. J Am Stat Assoc 1958; 53: 457-81
14. 14. Gehan EA. The determination of the number of patienis required in a preliminaly and follow-up trial of a new chemotherapeutic agent. J Chronic Dis 1961; 2: 346-53
15. 15. Advanced Colorectal Cancer Metaanalysis Project. Modulation of fluorouracil by leukovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992; 10: 896-903
16. 16. Herman R, Knuth A, Kleeberg O, et al. Sequential methotrexate and 5-fluorouracil vs 5-FU alone in metastatic colorectal cancer. Ann Oncol 1992; 3: 539-43
17. 17. The Nordic Gastrointestinal Tumour Adjuvant Therapy Group. Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial. J Clin Oncol 1989; 7: 1437-66
18. 18. Marsh JC, Bertino JR, Katz KH, et al. The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer. J Clin Oncol 1991; 9: 371-80
19. 19. Glimelius B, Gimman C, Graffman S, et al. Sequential methotrexat -5FU-leucovorin (MFL) in advanced colorectal cancer. Eur J Clin Oncol 1986; 22: 295-300
20. 20. Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment of 5-fluorouracil metabolism in L1210 cells. J Biol Chem 1981; 256: 1695-704
21. 21. Glimelius B. Biochemical modulation of 5-fluorouracil: a randomized comparison of sequential methotrexate, 5-fluorouracil and leucovorin versus sequential 5-fluorouracil and leucovorin in patients with advanced symptomatic colorectal cancer. Ann Oncol 1993; 4: 235-40