메뉴 건너뛰기




Volumn 32, Issue 10, 1996, Pages 1719-1726

Double biochemical modulation of 5-fluorouracil by methotrexate and levo-folinic acid in the treatment of advanced digestive tract malignancies

Author keywords

5 Fluorouracil; Double modulation; Gastrointestinal carcinomas; Levo folinic acid; Methotrexate; Pharmacokinetics

Indexed keywords

FLUOROURACIL; FOLINIC ACID; METHOTREXATE;

EID: 0030249114     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(96)00155-4     Document Type: Article
Times cited : (13)

References (35)
  • 1
    • 0018264312 scopus 로고
    • Chemotherapy of gastrointestinal cancer
    • 1. Moertel CG. Chemotherapy of gastrointestinal cancer. N Engl J Med 1978, 299, 1049-1052.
    • (1978) N Engl J Med , vol.299 , pp. 1049-1052
    • Moertel, C.G.1
  • 2
    • 0023462477 scopus 로고
    • Overview of current status and future direction on clinical trials with 5-fluorouracil in combination with folinic acid
    • 2. Grem JL, Hoth DF, Hamilton JM, King SA, Leyland-Jones B. Overview of current status and future direction on clinical trials with 5-fluorouracil in combination with folinic acid. Cancer Treat Rep 1987, 71, 1249-1253.
    • (1987) Cancer Treat Rep , vol.71 , pp. 1249-1253
    • Grem, J.L.1    Hoth, D.F.2    Hamilton, J.M.3    King, S.A.4    Leyland-Jones, B.5
  • 3
    • 0025991253 scopus 로고
    • Folinic acid + 5-fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer. Phase III study of GISCAD (Italian group for the study of digestive tract cancer)
    • 3. Labianca R, Pancera G, Aitini E, et al. Folinic acid + 5-fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer. Phase III study of GISCAD (Italian Group for the Study of Digestive Tract Cancer). Ann Oncol 1991, 2, 673-679.
    • (1991) Ann Oncol , vol.2 , pp. 673-679
    • Labianca, R.1    Pancera, G.2    Aitini, E.3
  • 4
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer. Evidence in terms of response rate
    • 4. Advanced Colorectal Cancer Meta-analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer. Evidence in terms of response rate. J Clin Oncol 1992, 10, 896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 5
    • 0019800298 scopus 로고
    • 5-Fluorouracil and methotrexate combined therapy: The effect of drug scheduling
    • 5. Mulder JH, Smink T, Van Putten LM. 5-Fluorouracil and methotrexate combined therapy: the effect of drug scheduling. Eur J Cancer Clin Oncol 1981, 17, 831-837.
    • (1981) Eur J Cancer Clin Oncol , vol.17 , pp. 831-837
    • Mulder, J.H.1    Smink, T.2    Van Putten, L.M.3
  • 6
    • 0020956002 scopus 로고
    • Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells
    • 6. Tattersall MHN. Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells. Semin Oncol 1983, 10 (Suppl. 2), 6-10.
    • (1983) Semin Oncol , vol.10 , Issue.SUPPL. 2 , pp. 6-10
    • Tattersall, M.H.N.1
  • 7
    • 0028219974 scopus 로고
    • Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer
    • 7. Advanced Colorectal Cancer Meta-Analysis Project. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. J Clin Oncol 1994, 12, 960-969.
    • (1994) J Clin Oncol , vol.12 , pp. 960-969
  • 8
    • 0024347268 scopus 로고
    • Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
    • 8. Poon MA, O'Connel MJ, Moertel CG, et al. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989, 10, 1407-1418.
    • (1989) J Clin Oncol , vol.10 , pp. 1407-1418
    • Poon, M.A.1    O'Connel, M.J.2    Moertel, C.G.3
  • 9
    • 0025945336 scopus 로고
    • Sequential combination of methotrexate (MTX), 5-fluorouracil (FU), and high-dose folinic acid (FA) in advanced colorectal cancer: Double biochemical modulation?
    • 9. Abad A, Rosell R, Pastor MC, et al. Sequential combination of methotrexate (MTX), 5-fluorouracil (FU), and high-dose folinic acid (FA) in advanced colorectal cancer: double biochemical modulation? Am J Clin Oncol 1991, 14, 393-396.
    • (1991) Am J Clin Oncol , vol.14 , pp. 393-396
    • Abad, A.1    Rosell, R.2    Pastor, M.C.3
  • 10
    • 0001239285 scopus 로고
    • Double modulation (DM) of 5-fluorouracil (5-FU) by methotrexate (MTX) and high-dose (HD) L-Leucovorin (L-LV) in advanced colorectal cancer (ACC)
    • abstract
    • 10. Romero A, Perez J, Cuevas M, et al. Double modulation (DM) of 5-fluorouracil (5-FU) by methotrexate (MTX) and high-dose (HD) L-Leucovorin (L-LV) in advanced colorectal cancer (ACC). Proc Am Soc Clin Oncol 1995, 14, 209 (abstract).
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 209
    • Romero, A.1    Perez, J.2    Cuevas, M.3
  • 11
    • 0017361019 scopus 로고
    • Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil
    • 11. Bertino JR, Sawicki WL, Lindquist CA. Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil. Cancer Res 1977, 37, 327-328.
    • (1977) Cancer Res , vol.37 , pp. 327-328
    • Bertino, J.R.1    Sawicki, W.L.2    Lindquist, C.A.3
  • 12
    • 0018700143 scopus 로고
    • Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: Explanation for drug synergism
    • 12. Cadman ED, Heimer R, Davis L. Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism. Science 1979, 205, 1135-1137.
    • (1979) Science , vol.205 , pp. 1135-1137
    • Cadman, E.D.1    Heimer, R.2    Davis, L.3
  • 13
    • 0019486367 scopus 로고
    • Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal carcinoma HCT-8
    • 13. Benz C, Cadman E. Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal carcinoma HCT-8. Cancer Res 1981, 41, 994-999.
    • (1981) Cancer Res , vol.41 , pp. 994-999
    • Benz, C.1    Cadman, E.2
  • 14
    • 0026100241 scopus 로고
    • The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer
    • 14. Marsh JC, Bertino JR, Katz KH, et al. The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer. J Clin Oncol 1991, 9, 371-380.
    • (1991) J Clin Oncol , vol.9 , pp. 371-380
    • Marsh, J.C.1    Bertino, J.R.2    Katz, K.H.3
  • 15
    • 0029881561 scopus 로고    scopus 로고
    • Significance of methotrexate serum levels achieved in patients with gastrointestinal malignancies treated with sequential methotrexate, L-folinic acid and 5-fluorouracil
    • 15. Comella P, Palmieri G, Beneduce G, et al. Significance of methotrexate serum levels achieved in patients with gastrointestinal malignancies treated with sequential methotrexate, L-folinic acid and 5-fluorouracil. Oncology 1996, 53, 198-203.
    • (1996) Oncology , vol.53 , pp. 198-203
    • Comella, P.1    Palmieri, G.2    Beneduce, G.3
  • 17
    • 0025663391 scopus 로고
    • The calculation of received dose intensity
    • 17. Hryniuk WH, Goodyear M. The calculation of received dose intensity. J Clin Oncol 1990, 8, 1935-1937.
    • (1990) J Clin Oncol , vol.8 , pp. 1935-1937
    • Hryniuk, W.H.1    Goodyear, M.2
  • 18
    • 33745582805 scopus 로고
    • Berkeley, California, University of California Press
    • 18. Dixon WJ. BMDP Statistical Software. Berkeley, California, University of California Press, 1988.
    • (1988) BMDP Statistical Software
    • Dixon, W.J.1
  • 19
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • 19. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53, 457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 20
    • 0017365573 scopus 로고
    • Design and analysis of randomized clinical trials requiring prolonged observations of each patient. II. Analysis and examples
    • 20. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observations of each patient. II. Analysis and examples. Br J Cancer 1977, 35, 1-39.
    • (1977) Br J Cancer , vol.35 , pp. 1-39
    • Peto, R.1    Pike, M.C.2    Armitage, P.3
  • 21
    • 0000336139 scopus 로고
    • Regression models and life tables
    • 21. Cox DR. Regression models and life tables. J R Stat Soc (B) 1972, 34, 187-200.
    • (1972) J R Stat Soc (B) , vol.34 , pp. 187-200
    • Cox, D.R.1
  • 22
    • 50549174560 scopus 로고
    • The determination of the number of patients required in a preliminary and follow-up trial of a new chemotherapeutic agent
    • 22. Gehan EA. The determination of the number of patients required in a preliminary and follow-up trial of a new chemotherapeutic agent. J Chronic Dis 1961, 13, 346-353.
    • (1961) J Chronic Dis , vol.13 , pp. 346-353
    • Gehan, E.A.1
  • 23
    • 0026507592 scopus 로고
    • Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: A phase I-II study
    • 23. Machover D, Grison X, Goldschmidt E, et al. Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study. J Natl Cancer Inst 1992, 84, 321-327.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 321-327
    • Machover, D.1    Grison, X.2    Goldschmidt, E.3
  • 24
    • 0028241595 scopus 로고
    • Phase II trial of 5-fluorouracil and the natural l isomer of folinic acid in the treatment of advanced colorectal carcinoma
    • 24. Rosso R, Mazzei T, Sobrero A, et al. Phase II trial of 5-fluorouracil and the natural l isomer of folinic acid in the treatment of advanced colorectal carcinoma. Eur J Cancer 1994, 30A, 338-343.
    • (1994) Eur J Cancer , vol.30 A , pp. 338-343
    • Rosso, R.1    Mazzei, T.2    Sobrero, A.3
  • 25
    • 0025762832 scopus 로고
    • Sequential high-dose methotrexate and fluorouracil combined with doxorubicin. A step ahead in the treatment of advanced gastric cancer: A trial of the European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group
    • 25. Wils JA, Klein HO, Wagener DJTh, et al. Sequential high-dose methotrexate and fluorouracil combined with doxorubicin. A step ahead in the treatment of advanced gastric cancer: a trial of the European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group. J Clin Oncol 1991, 9, 827-831.
    • (1991) J Clin Oncol , vol.9 , pp. 827-831
    • Wils, J.A.1    Klein, H.O.2    Wagener, D.J.T.H.3
  • 26
    • 0026548710 scopus 로고
    • FAMTX versus etoposide, doxorubicin, and cisplatin; A random assignment trial in gastric cancer
    • 26. Kelsen D, Atiq OT, Saltz L, et al. FAMTX versus etoposide, doxorubicin, and cisplatin; a random assignment trial in gastric cancer. J Clin Oncol 1992, 10, 541-548.
    • (1992) J Clin Oncol , vol.10 , pp. 541-548
    • Kelsen, D.1    Atiq, O.T.2    Saltz, L.3
  • 27
    • 0028334662 scopus 로고
    • Etoposide, doxorubicin and cisplatin (EAP) treatment in advanced gastric carcinoma: A multicentre study of the Italian Trials in Medical Oncology (ITMO) Group
    • 27. Bajetta E, Di Bartolomeo M, De Braud F, et al. Etoposide, doxorubicin and cisplatin (EAP) treatment in advanced gastric carcinoma: a multicentre study of the Italian Trials in Medical Oncology (ITMO) Group. Eur J Cancer 1994, 30A, 596-900.
    • (1994) Eur J Cancer , vol.30 A , pp. 596-900
    • Bajetta, E.1    Di Bartolomeo, M.2    De Braud, F.3
  • 28
    • 0028032976 scopus 로고
    • FAM combination versus PELF combination (cisplatin, epirubicin, leucovorin, 5-fluorouracil) in advanced gastric cancer. A prospective randomized trial of the Italian Oncology Group for Clinical Research (GOIRC)
    • 28. Cocconi G, Bella M, Zironi S, et al. FAM combination versus PELF combination (cisplatin, epirubicin, leucovorin, 5-fluorouracil) in advanced gastric cancer. A prospective randomized trial of the Italian Oncology Group for Clinical Research (GOIRC). J Clin Oncol 1994, 12, 2687-2693.
    • (1994) J Clin Oncol , vol.12 , pp. 2687-2693
    • Cocconi, G.1    Bella, M.2    Zironi, S.3
  • 29
    • 0028323029 scopus 로고
    • Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma
    • 29. Conti JA, Kemeny N, Seiter K, et al. Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma. J Clin Oncol 1994, 12, 695-700.
    • (1994) J Clin Oncol , vol.12 , pp. 695-700
    • Conti, J.A.1    Kemeny, N.2    Seiter, K.3
  • 30
    • 0028213430 scopus 로고
    • Weekly therapy with folinic acid (FA) and high-dose 5-fluorouracil (5-FU) 24-hour infusion in pretreated patients with metastatic colorectal carcinoma
    • 30. Weh HJ, Wilke HJ, Dierlamm J, et al. Weekly therapy with folinic acid (FA) and high-dose 5-fluorouracil (5-FU) 24-hour infusion in pretreated patients with metastatic colorectal carcinoma. Ann Oncol 1994, 5, 233-237.
    • (1994) Ann Oncol , vol.5 , pp. 233-237
    • Weh, H.J.1    Wilke, H.J.2    Dierlamm, J.3
  • 31
    • 0028351433 scopus 로고
    • Protracted venous infusion 5-fluorouracil and interferon in advanced and refractory colorectal cancer
    • 31. Findlay M, Hill A, Cunningham D, et al. Protracted venous infusion 5-fluorouracil and interferon in advanced and refractory colorectal cancer. Ann Oncol 1994, 5, 239-243.
    • (1994) Ann Oncol , vol.5 , pp. 239-243
    • Findlay, M.1    Hill, A.2    Cunningham, D.3
  • 32
    • 0024342059 scopus 로고
    • Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group
    • 32. Valone FH, Friedman MA, Wittlinger PS, et al. Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group. J Clin Oncol 1989, 7, 1427-1436.
    • (1989) J Clin Oncol , vol.7 , pp. 1427-1436
    • Valone, F.H.1    Friedman, M.A.2    Wittlinger, P.S.3
  • 33
    • 0028175144 scopus 로고
    • Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
    • 33. Buroker R, O'Connell MJ, Wieand HS, et al. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 1994, 12, 14-20.
    • (1994) J Clin Oncol , vol.12 , pp. 14-20
    • Buroker, R.1    O'Connell, M.J.2    Wieand, H.S.3
  • 34
    • 0027954007 scopus 로고
    • Oral doxifluridine in elderly patients with metastatic colorectal cancer: A muticenter phase II study
    • 34. Falcone A, Pfanner E, Ricci S, et al. Oral doxifluridine in elderly patients with metastatic colorectal cancer: a muticenter phase II study. Ann Oncol 1994, 5, 760-762.
    • (1994) Ann Oncol , vol.5 , pp. 760-762
    • Falcone, A.1    Pfanner, E.2    Ricci, S.3
  • 35
    • 0023747871 scopus 로고
    • The importance of dose intensity in the outcome of chemotherapy
    • In De Vita VT Jr, Hellman S, Rosenberg SA, eds. Philadelphia, Lippin-cott
    • 35. Hryniuk WM. The importance of dose intensity in the outcome of chemotherapy. In De Vita VT Jr, Hellman S, Rosenberg SA, eds. Important Advances in Oncology 1988. Philadelphia, Lippin-cott, 1988, 125-128.
    • (1988) Important Advances in Oncology 1988 , pp. 125-128
    • Hryniuk, W.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.