Adenosine prevents the death of mesencephalic dopaminergic neurons by a mechanism that involves astrocytes

Journal of Neurochemistry

Volumn 72, Issue 5, 1999, Pages 2074-2082

  Michel, Patrick P ^a,b   Marien, Marc ^b   Ruberg, Merle ^a   Colpaert, Francis ^b   Agid, Yves ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Adenosine; Antimitotic agent; ATP; Dopaminergic neurons; Neuroprotection; Parkinson's disease

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE DEAMINASE INHIBITOR; BUCLADESINE; CYTARABINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; HYPOTHESIS; MESENCEPHALON; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; CELL DEATH; CELL DIVISION; CELLS, CULTURED; DOPAMINE; MESENCEPHALON; NERVE GROWTH FACTORS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC; TIME FACTORS;

ANIMALIA;

EID: 0032971723     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0722074.x     Document Type: Article

References (62)

1. Abbracchio M. P. (1997) ATP in brain function, in Purinergic Approaches in Experimental Therapeutics (Jacobson K. A. and Jarvis M. F., eds), pp. 383-404. Wiley-Liss, New York.
2. Abbracchio M. P., Saffrey M. J., Hopker V., and Burnstock G. (1994) Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 59, 67-76.
3. Bell M. J., Kochanek P. M., Carcillo J. A., Mi Z., Schiding J. K., Wisniewski S. R., Clark R. S., Dixon C. E., Marion D. W., and Jackson E. (1998) Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat. J. Neurotrauma 15, 163-170.
4. Burnstock G. (1990) Overview. Purinergic mechanisms. Ann. NY Acad. Sci. 603, 1-17.
5. Casper D., Mytilineou C., and Blum M. (1991) EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cultures. J. Neurosci. Res. 30, 372-381.
6. Ceruti S., Malorni W., Brambilla R., Cattabeni F., and Abbracchio M. P. (1997) 2-Chloroadenosine-induced apoptosis of human ADF astroglioma cells. Soc. Neurosci. Abstr. 23, 71.
7. Chow S. C., Kass G. E., and Orrenius S. (1997) Purines and their roles in apoptosis. Neuropharmacology 36, 1149-1156.
8. Ciccarelli R., Di Iorio P., Ballerini P., Ambrosini G., Giuliani P., Tiboni G. M., and Caciagli F. (1994) Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J. Neurosci. Res. 39, 556-566.
9. Colpaert F. C. (1994) Noradrenergic mechanisms in Parkinson's disease: a theory, in Noradrenergic Mechanisms in Parkinson's Disease (Briley M. and Marien M., eds), pp. 225-254. CRC Press, Boca Raton, Florida.
10. Damier P., Hirsch E. C., Zhang P., Agid Y., and Javoy-Agid F. (1993) Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience 52, 1-6.
11. Di Virgilio F., Ferrari D., Chiozzi P., Falzoni S., Sanz J. M., Dal Susino M., Mutini C., Hanau S., and Baricordi O. R. (1996) Purinoceptor function in the immune system. Drug Dev. Res. 39, 319-329.
12. Dixon A. K., Gubitz A. K., Sirinathsinghji D. J., Richardson P. J., and Freeman T. C. (1996) Tissue distribution of adenosine receptor mRNA in the rat. Br. J. Pharmacol. 118, 1461-1468.
13. Driscoll B. F., Law M. J., and Crane A. M. (1993) Cell damage associated with changing the medium of mesencephalic cultures in serum-free medium is mediated via N-methyl-D-aspartate receptors. J. Neurochem. 56, 1201-1206.
14. Du X. and Iacovitti L. (1995) Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons. J. Neurosci. 15, 5420-5427.
15. Fox I. H. and Kelley W. N. (1978) The role of adenosine and 2′deoxyadenosine in mammalian cells. Annu. Rev. Biochem. 47, 655-686.
16. 3H-adenine labeled hypothalamic synaptosomes. Acta Physiol. Scand. 106, 97-107.
17. 2A antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 55, PL61-PL65.
18. Graham F. L. and Whitmore G. F. (1970) Studies in mouse L-cells on the incorporation of 1-β-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-β-D-arabinofuranosylcytosine 5′-triphosphate. Cancer Res. 30, 2636-2644.
19. 3H]adenosine from rat brain synaptosomal preparations. J. Neurochem. 64, 2105-2110.
20. Hagberg H., Andersson P., Lacarewicz J., Jacobson I., Butcher S., and Sandberg M. (1987) Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J. Neurochem. 49, 227-231.
21. Higgins M. J., Hosseinzadeh H., MacGregor D. G., Ogilvy H., and Stone T. W. (1994) Release and actions of adenosine in the central nervous system. Pharm. World Sci. 16, 62-68.
22. Höpker V. H., Saffrey M. J., and Burnstock G. (1996) Neurite outgrowth of striatal neurons in vitro: involvement of purines in the growth-promoting effect of myenteric plexus explants. Int. J. Dev. Neurosci. 14, 439-451.
23. Huffaker T., Corcoran T., and Wagner J. A. (1984) Adenosine inhibits cell division and promotes neurite extension in PC12 cells. J. Cell. Physiol. 120, 188-196.
24. Hunot S., Brugg B., Ricard D., Michel P. P., Muriel M. P., Ruberg M., Faucheux B. A., Agid Y., and Hirsch E. C. (1997) Nuclear translocation of NFκB is increased in dopaminergic neurons of patients with Parkinson disease. Proc. Natl. Acad. Sci. USA 94, 7531-7536.
25. Ijzerman A. D. and Van Der Wenden N. M. (1997) Modulators of adenosine uptake, release and inactivation, in Purinergic Approaches in Experimental Therapeutics (Jacobson K. A. and Jarvis M. F., eds), pp. 129-148. Wiley-Liss, New York.
26. Illes P., Nieber K., and Norenberg W. (1996) Electrophysiological effects of ATP on brain neurones. J. Auton. Pharmacol. 16, 407-411.
27. Jones P. A., Smith R. A., and Stone T. W. (1998) Protection against kainate-induced excitotoxicity by adenosine A2a receptor agonists and antagonists. Neuroscience 85, 229-237.
28. Kawamoto J. C. and Barrett J. N. (1986) Cryopreservation of primary neurons for tissue culture. Brain Res. 384, 84-93.
29. Kegel B., Braun N., Heine P., Maliszewski C. R., and Zimmermann H. (1997) An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain. Neuropharmacology 36, 1189-1200.
30. Kennedy C. and Leff P. (1995) How should P2X purinoceptors be classified pharmacologically? Trends Pharmacol. Sci. 16, 168-174.
31. Kume A., Takahashi A., and Hashizume Y. (1993) Neuronal cell loss of the striatonigral system in multiple system atrophy. J. Neurol. Sci. 117, 33-40.
32. Lin L. F. H., Doherty D. H., Lile J. D., Bektesh S., and Collins F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132.
33. Manome Y., Wen P. Y., Dong Y., Tanaka T., Mitchell B. S., Kufe D. W., and Fine H. A. (1996) Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat. Med. 2, 567-573.
34. Marangos P. J. and Boulenger J. P. (1985) Basic and clinical aspects of adenosine neuromodulation. Neurosci. Biobehav. Rev. 9, 421-430.
35. Marey-Semper I., Gelman M., and Levi-Strauss M. (1993) The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra. Eur. J. Neurosci. 5, 1029-1034.
36. Michel P. P. and Agid Y. (1996) Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons. J. Neurochem. 67, 1633-1642.
37. Michel P. P., Dandapani B. K., Knusel B., Sanchez-Ramos J. R., and Hefti F. (1990) Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. J. Neurochem. 54, 1102-1109.
38. Michel P. P., Ruberg M., and Agid Y. (1997a) Rescue of mesencephalic dopamine neurons by anticancer drug cytosine arabinoside. J. Neurochem. 69, 1499-1507.
39. Michel P. P., Marien M., Ruberg M., Colpaert F., and Agid Y. (1997b) ATP and adenosine promote survival and differentiation of mesencephalic dopaminergic neurons. Soc. Neurosci. Abstr. 23, 893.
40. National Research Council (1996) Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C.
41. Neary J. T., Rathbone M. P., Cattabeni F., Abbrachio M. P., and Burnstock G. (1996) Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Pharmacol. Sci. 19, 13-18.
42. Neary J. T., McCarthy M., Kang Y., and Zuniga S. (1998) Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures. Neurosci. Lett. 242, 159-162.
43. Palmer T. M. and Stiles G. L. (1995) Adenosine receptors. Neuropharmacology 34, 683-694.
44. 2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Br. J. Pharmacol. 111, 191-198.
45. Plagemann P. G., Wohlhueter R. M., and Woffendin C. (1988) Nucleoside and nucleobase transport in animal cells. Biochim. Biophys. Acta 947, 405-443.
46. Rathbone M. P., Middlemiss P. J., Gysbers J. W., Deforge S., Costello P., and Del Maestro R. F. (1992) Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types. In Vitro Cell. Dev. Biol. 28A, 529-536.
47. Rodwell V. W. (1994) Metabolism of purine and pyrimidine nucleotide, in Harper's Biochemistry (Murray R. K., Granner D. K., Mayes P. A., and Rodwell V. W., eds), pp. 363-377. Appleton and Lange, Norwalk, Connecticut.
48. Rosenberg P. A. and Aizenman E. (1989) Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci. Lett. 103, 162-168.
49. Rothman T. P., Specht L. A., Gershon M. D., Joh T. H., Teitelman G., Pickel V. M., and Reis D. J. (1980) Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system. Proc. Natl. Acad. Sci. USA 77, 6221-6225.
50. Rousselet A., Fetler L., Chamak B., and Prochiantz A. (1988) Rat mesencephalic neurons in culture exhibit different morphological traits in the presence of media conditioned on mesencephalic or striatal astroglia. Dev. Biol. 129, 495-504.
51. Sajjadi F. G., Takabayashi K., Foster A. C., Domingo R. C., and Firenstein G. S. (1996) Inhibition of TNF-α expression by adenosine: role of A3 adenosine receptors. J. Immunol. 156, 3435-3442.
52. 3H]noradrenaline from rat hypothalamic slices: origin and modulation by α-2 adrenoceptors. Neuroscience 82, 511-520.
53. Sweeney M. I. (1996) Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins. J. Neurochem. 67, 81-88.
54. Takeshima T., Johnston J. M., and Commissiong J. W. (1994) Mesencephalic type I astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J. Neurosci. 14, 4769-4779.
55. Unterharnscheidt F. (1995) A neurologist's reflections on boxing. V. Concluding remarks. Rev. Neurol. 23, 1027-1032.
56. Vesely J., Havlicek L., Strnad M., Blow J. J., Donella-Deana A., Pinna L., Lethma D. S., Kato J., Detivaud L., Leclerc S., and Meijer L. (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224, 771-786.
57. Von Lubitz D. K. (1997) Adenosine and acute treatment of cerebral ischemia and stroke. "Put out more flags," in Purinergic Approaches in Experimental Therapeutics (Jacobson K. A. and Jarvis M. F., eds), pp. 449-470. Wiley-Liss, New York.
58. Wenning G. K., Tison F., Ben Shlomo Y., Daniel S. E., and Quinn N. P. (1997) Multiple system atrophy: a review of 203 pathological proven cases. Mov. Disord. 12, 133-147.
59. Zhang G., Franklin P. H., and Murray T. F. (1993) Manipulation of endogenous adenosine in the rat piriform cortex modulates seizure susceptibility. J. Pharmacol. Exp. Ther. 264, 1415-1424.
60. Zhang Y. X., Yamashita H., Sawamoto N., and Nakamura S. (1996) ATP induces release of newly synthetized dopamine in the rat striatum. Neurochem. Int. 28, 395-400.
61. Zimmermann H. (1994) Signaling via ATP in the nervous system. Trends Neurosci. 17, 420-426.
62. Zimmermann H. (1996) Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog. Neurobiol. 49, 589-618.