Systemic thermal injury in anesthetized rabbits causes early pulmonary vascular injury that is not ablated by lazaroids

Canadian Journal of Anaesthesia

Volumn 46, Issue 2, 1999, Pages 142-147

  Miles, Duncan ^a   Hurst, Thomas S ^a   Saxena, A ^b   Mayers, Irvin ^c   Johnson, David H ^a,b,d  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; LAZAROID;

ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTICLE; BURN SHOCK; CONTROLLED STUDY; GAS EXCHANGE; HEMODYNAMICS; LEUKOCYTE COUNT; LUNG ARTERIOVENOUS SHUNT; LUNG ARTERY PRESSURE; LUNG INJURY; LUNG VASCULAR RESISTANCE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RABBIT; THERMAL INJURY;

EID: 0032971209     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03012548     Document Type: Article

References (20)

1. Horton JW, Baxter CR, White DJ. Differences in cardiac responses to resuscitation from burn shock. Surg Gynecol Obstet 1989; 168: 201-13.
2. Horton JW, White J, Baxter CR. The role of oxygen-derived free radicals in burn-induced myocardial contractile depression. J Burn Care Rehab 1988; 9: 589-98.
3. Mulligan MS, Yeh CG, Rudolph AR, Ward PA. Protective effects of soluble CR1 in complement-and neutrophil-mediated tissue injury. J Immunol 1992; 148: 1479-85.
4. Glauser MP, Zanetti G, Baumgartner J-D, Cohen J. Septic shock: pathogenesis. Lancet 1991; 338: 732-6.
5. Horton JW, White DJ. Diminished cardiac contractile response to burn injury in aged guinea pigs. J Trauma 1993; 34: 429-36.
6. Choi M, Ehrlich HP. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am J Pathol 1993; 142: 519-28.
7. Jin LJ, LaLonde C, Demling RH. Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release. J Appl Physiol 1986; 61: 103-12.
8. Demling RH, Zhu D, LaLonde C. Early pulmonary and hemodynamic effects of a chest wall burn (effect of ibuprofen). Surgery 1988; 104: 10-7.
9. Demling RH. Smoke inhalation injury. New Horiz 1993; 1: 422-34.
10. Johnson DH, Hurst TS, Mayers I. The effects of U74389G, a 21-aminosteroid, upon pulmonary vascular resistance following a scald. J Burn Care Rehab 1997; 18: 395-401.
11. Crum RL, Dominic W, Hansbrough JF, Shackford SR, Brown MR. Cardiovascular and neurohumoral responses following burn injury. Arch Surg 1990; 125: 1065-9.
12. G-L-methyl-arginine in a rabbit model of thermal injury. Am J Emerg Med 1996; 14: 629-34.
13. Mosher M, Hurst TS, Mayers I, Johnson DH. Lazaroids -not nitric oxide synthetase inhibitors - improve hemodynamics after thermal injury in anesthetized guinea pigs. J Burn Care Rehab 1996; 17: 294-301.
14. Youn Y-K, LaLonde C, Demling R. Oxidants and the pathophysiology of burn and smoke inhalation injury. Free Radic Biol Med 1992; 12: 409-15.
15. Hansbrough JF, Wikström T, Braide M, et al. Effects of E-selectin and P-selectin blockade on neutrophil sequestration in tissues and neutrophil oxidative burst in burned rats. Crit Care Med 1996; 24: 1366-72.
16. Mandrup-Poulsen T, Wogensen LD, Jensen M, et al. Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Crit Care Med 1995; 23: 26-33.
17. Gore DC, Honeycutt D, Jaboor F, Barrow RE, Wolfe RR, Herndon DN. Propranolol diminishes extremity blood flow in burned patients. Ann Surg 1991; 213: 568-74.
18. Saez JC, Ward PH, Gunther B, Vivaldi E. Superoxide radical involvement in the pathogenesis of burn shock. Circ Shock 1984; 12: 229-39.
19. Demling RH, LaLonde C. Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post resuscitation period. J Trauma 1990; 30: 69-74.
20. Kennedy TP, Rao NV, Noah W, et al. Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J Clin Invest 1990; 86: 1565-73.