Lazaroids - Not nitric oxide synthetase inhibitors - Improve hemodynamics after thermal injury in anesthetized guinea pigs

Journal of Burn Care and Rehabilitation

Volumn 17, Issue 4, 1996, Pages 294-301

  Mosher, Mat ^b   Hurst, Thomas S ^b   Mayers, Irvin ^b   Johnson, David H ^a  

^a ROYAL UNIVERSITY HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; FREE RADICAL; LAZAROID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BURN SHOCK; CONTROLLED STUDY; GAS EXCHANGE; GUINEA PIG; HEART OUTPUT; HEART PERFORMANCE; HEMODYNAMICS; LIPID PEROXIDATION; MEAN ARTERIAL PRESSURE; NONHUMAN; SYSTEMIC VASCULAR RESISTANCE; THERMAL INJURY; VASOCONSTRICTION;

EID: 0029798297     PISSN: 02738481     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004630-199607000-00003     Document Type: Article

References (43)

1. Marshall WG Jr, Dimick AR. The natural history of major burns with multiple subsystem failure. J Trauma 1983;23: 102-5.
2. Baxter CR, Fluid volume and electrolyte changes in the early postburn period. Clin Plast Surg 1974;1:693-705.
3. Cotran RS. The delayed and prolonged vascular leakage in inflammation; II: an electron microscope study of the vascular response after thermal injury. Am J Pathol 1965;46:589.
4. Horton JW, Baxter CR, White J. Difference in cardiac responses to resuscitation from burn shock. Surg Gynecol Obstet 1982;168:201-6.
5. Horton JW, White J, Baxter CR The role of oxygen derived free radicals in burn-induced myocardial contractile depression. J Burn Care Rehabil 1988;9:589-94.
6. Mulligan MS, Yeh CG, Rudolph AR, Ward PA. Protective effects of soluble CR1 in complement- and neutrophil-mediated tissue injury. J Immunol 1992;148:1479-85.
7. Glauser MP, Zanetti G, Baumgartner J-D, Cohen J. Septic shock: pathogenesis. Lancet 1991;338:732-9.
8. Solomkin JS. Neutrophil disorders in burn injury: complement, cytokines, and organ injury. J Trauma 1990;30(suppl): S80-S5.
9. Mileski W, Borgstrom D, Lighrfoot E, Rothlein R, Fanes R, Lipsky P, et al. Inhibition of leukocyte-endothelial adherence following thermal injury. J Surg Res 1992;52:334-9.
10. Becker WK, Shippee RL, McManus AT, Mason AD, Pruitt BA Jr. Kinetics of nitrogen oxide production following experimental thermal injury in rats. J Trauma 1993;34:855-62.
11. Bamberger T, Masson I, Mathieu J, Chauvelot-Moachon L, Giroud JP, Florentin I. Nitric oxide mediates the depression of lymphoproliferative responses following burn injury in rats. Biomed Pharmacother 1992;46:495-500.
12. Horton JW, White DJ. Diminished cardiac contractile response to burn injury in aged guinea pigs. J Trauma 1993; 34:429-36.
13. Choi M, Ehrlich HP. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am J Pathol 1993; 142:519-28.
14. G-monomethyl-L-arginine does not restore loss of hypoxic pulmonary vasoconstriction induced by TNF-α. J Appl Physiol 1993;75:618-25.
15. Johnson D, Hurst T, Prasad K, Wilson T, Saxena A, Murphy F, Mayers I. Lazaroid pretreatment preserves gas exchange in endotoxin-treated dogs. J Crit Care 1994;9:213-23.
16. Feldman HA. Families of lines: random effects in linear regression analysis. J Appl Physiol 1988;64:1721-32.
17. Crum RL, Dominic W, Hansbrough JF, Shackford SR, Brown MR. Cardiovascular and neurohumoral responses following burn injury. Arch Surg 1990;125:1065-9.
18. DePasquale N, Burch G, Hyman A. Pulmonary venous response to immersion hyperthermia and hypothermia. Am Heart J 1965;70:486-93.
19. Demling RH, Deguang Z, LaLonde C. Early pulmonary and hemodynamic effects of a chest wall burn (effect of ibuprofen). Surgery 1988;104:10-7.
20. Miller JG, Carruthers HR, Burd DAR. An algorithmic approach to the management of cutaneous burns. Burns 1992; 18:200-11.
21. Dries DJ, Waxman K. Adequate resuscitation of burn patients may not be measured by urine output and vital signs. Crit Care Med 1991;19:327-9.
22. Aikawa N, Wakabayashi G, Masakazu U, Shinozawa Y. Regulation of renal function in thermal injury. J Trauma 1990; 30(12):S174-S178.
23. Cioffi WG Jr, Vaughan GM, Heironimus JD, Jordan BS, Mason AD, Pruitt BA. Dissociation of blood volume and flow in regulation of salt and water balance in burn patients. Ann Surg 1991;214(suppl):213-20.
24. Du G-B, Slater H, Goldfarb IW. Influences of different resuscitation regimens on acute early weight gain in extensively burned patients. Burns 1991;17:147-50.
25. Youn Y-K, LaLonde C, Demling R. Oxidants and the pathophysiology of burn and smoke inhalation injury. Free Radic Biol Med 1992;12:409-15.
26. Gore DC, Honeycutt D, Jahoor F, Barrow RE, Wolfe RR, Herndon DN. Propranolol diminishes extremity blood flow in burned patients. Ann Surg 1991;213:568-74.
27. Saez JC, Ward PH, Gunther B, Vivaldi E. Superoxide radical involvement in the pathogenesis of burn shock. Circ Shock 1984;12:229-39.
28. Demling R, LaLonde C, Knox J, Shu DG, Daryani R. Fluid resuscitation with desferroxamine prevents systemic burn induced oxidant injury. J Trauma 1991;31:538-44.
29. Demling RH, LaLonde C. Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post resuscitation period. J Trauma 1990;30:69-73.
30. Kennedy TP, Rao NV, Noah W, Michael JR, Jafri MH Jr, Gurtner GH, et al. Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J Clin Invest 1990;86:1565-73.
31. Horton JW, White DJ. U-74, 500A inhibition of burn-induced cardiac dysfunction. J Surg Res 1992;52:251-7.
32. Olsen KS, Videbaek C, Agerlin N, Kroll M, Boge-Rasmussen T, Paulson OB, et al. The effect of tirilazad mesylate (U74006F) on cerebral oxygen consumption, and reactivity of cerebral blood flow to carbon dioxide in healthy volunteers. Anesthesiology 1993;79:666-71.
33. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992;257:387-9.
34. Hare JM, Loh E, Creager MA, Colucci WS. Nitric oxide inhibits the positive inotropic response to β-adrenergic stimulation in humans with left ventricular dysfunction. Circulation 1995;92:2198-203.
35. Freeman B. Free radical chemistry of nitric oxide: looking at the dark side. Chest 1994;105(suppl):79S-84S.
36. Garcia NM, Horton JW, White DJ, Walker PB, Morton DP. The contribution of nitric oxide to post burn cardiac dysfunction [abstract]. Circ Shock 1993;40(suppl 2):226.
37. G-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxcmic dogs. Crit Care Med 1994;22: 1835-40.
38. w-amino-L-arginine, an inhibitor of nitric oxide synthetase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. J Exp Med 1992;176:1175-82.
39. Petros A, Bennett D, Vallance P. Effect of nitric oxide synthetase inhibitors on hypotension in patients with septic shock. Lancet 1991;338:1557-8.
40. Li Juan Jin, LaLonde C, Demling RH. Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release. J Appl Physiol 1986;61:103-12.
41. Summer WR. Adult respiratory distress syndrome. In: Haponik EF, Muster AM, editors. Respiratory injury: smoke inhalation and burns. New York: McGraw-Hill 1990:73-113.
42. G-L-methyl-arginine in a rabbit model of thermal injury. Am J Emerg Med. In press.
43. Liu S, Crawley DE, Barnes PJ, Evans TW. Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis 1991;143:32-7.