Reduced purine 5'-nucleotidase activity in lymphocytes of patients with systemic lupus erythematosus: Results of a pilot study

Annals of the Rheumatic Diseases

Volumn 58, Issue 2, 1999, Pages 122-125

  Stolk, Jan N ^a   De Koning, Diana G M ^a   Pennings, Arie H ^a   De Abreu, Ronney A ^a   Van De Putte, Leo B A ^a   Boerbooms, Agnes M Th ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; HUMAN; LYMPHOCYTE; MALE; PILOT STUDY; PRIORITY JOURNAL; PURINE METABOLISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0032971033     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.58.2.122     Document Type: Article

References (16)

1. 1 Tsokos GC. An overview of cellular immune function in systemic lupus erythematosus. Chapter 2. In: Lahita RG, ed. Systemic lupus erythematosus. 2nd edition. New York: Churchill Livingstone, 1992.
2. 2 Horwitz DA. Systemic lupus erythematosus: generalized autoimmunity arising from disordered immune regulation. Chapter 69. In: McCarty DJ, Koopman WJ, eds. Arthritis and allied conditions. 12th edition. Philadelphia: Lea and Febiger, 1993.
3. 3 Thompson LF, Seegmiller JE. Adenosine deaminase deficiency and severe combined immunodeficiency disease. Adv Enzymol 1980;51:167-210.
4. 4 Markert ML. Purine nucleoside phosphorylase deficiency. Immunodeficiency Rev 1991;3:45-81.
5. 5 Sunderman FW jr. The clinical biochemistry of 5'-Nucleotidase. Ann Clin Lab Sci 1990;20:123-39.
6. 6 Stolk JN, De Abreu RA, Boerbooms AMTh, de Koning DGM, de Graaf R, Kerstens PJSM, et al. Purine enzyme activities in peripheral mononuclear cells: comparison of a new non-radiochemical high-performance liquid chromatography procedure and a radiochemical thin-layer chromatography procedure. J Cromatogr B 1995;666:33-43.
7. 7 Stolk JN, Boerbooms AMTh, De Abreu RA, Kerstens PJSM, de Koning DGM, de Graaf R, Mulder J, et al. Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls? Ann Rheum Dis 1996;55:733-8.
8. 8 Stolk JN, Boerbooms AMTh, De Abreu RA, de Koning DGM, van Beusekom HJ, Hissink Muller W, et al. Reduced thiopurine-methyltransferase activity and development of side effects on azathioprine in the treatment of rheumatoid arthritis. Arthritis Rheum 1998;41:1858-66.
9. 9 Edwards NL, Recker D, Manfredi J, Rembecki R, Fox IH. Regulation of purine metabolism by plasma membrane and cytoplasmic 5'-nucleotidase. Am J Physiol 1982;243: C270-7.
10. 10 Edwards NL, Gelfand EW, Burk L, Dosch HM, Fox IH. Distribution of 5'-nucleotidase in human lymphoid tissues. Proc Natl Acad Sci USA 1979;7:3474-6.
11. 11 Thompson LF, Ruedi JM, Low MG, Clement LT. Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies. J Immunol 1987;139:4042-8.
12. 12 Stone TW, Simmonds HA. Clinical consequences of aberrant purine metabolism. Chapter II. In: Stone TW, Simmonds HA, eds. Purines: basic and clinical aspects. Dordrecht: Kluwer Academic Publishers, 1991.
13. 13 Carson DA, Carrera CJ, Wasson DB, Iizasa T. Deoxyadenosine-resistent human T lymphoblasts with elevated 5'-nucleotidase activity. Biochim Biophys Acta 1991;1091:22-8.
14. 14 McCurdy D, Tai LQ, Frias S, Wang Z. Delayed repair of DNA damage by ionizing radiation in cells from patients with juvenile systemic lupus erythematosus and rheumatoid arthritis. Radiat Res 1997;147:48-54.
15. 15 Palmer RG, Dore CJ, Denman AM. Sister-chromatid exchange frequencies in lymphocytes of controls and patients with connective tissue diseases. Mutat Res 1986;162:113-20.
16. 16 Gadangi P, Longaker M, Naime D, Levin RI, Recht PA, Montesinos MC, et al. The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J Immunol 1996;156:1937-41.