Development of HIV/AIDS vaccine using chimeric gag-env virus-like particles

Biological Chemistry

Volumn 380, Issue 3, 1999, Pages 353-364

  Kang, C Yong ^a   Luo, Lizhong ^a   Wainberg, Mark A ^b   Li, Yan ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Baculovirus expression system; Chimeric gag V3 proteins; Cytotoxic T lymphocyte; HIV AIDS; Immune response; Vaccine; Virus like particles

Indexed keywords

CHEMOKINE RECEPTOR; GAG PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYBRID PROTEIN; NEUTRALIZING ANTIBODY; PROTEIN PRECURSOR; PROTEINASE; VIRUS PROTEIN; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ANTIGENICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR IMMUNITY; CHIMERA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DELETION MUTANT; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENE MAPPING; HUMAN IMMUNODEFICIENCY VIRUS 2; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOGENICITY; IMMUNOPRECIPITATION; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; VIRUS PARTICLE; WESTERN BLOTTING;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; ORYCTOLAGUS CUNICULUS; SPODOPTERA FRUGIPERDA; UNIDENTIFIED BACULOVIRUS;

EID: 0032970492     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.047     Document Type: Article

References (46)

1. Aldovini, A., and Young, R.A. (1990). Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J. Virol. 64, 1920-1926.
2. Berzofsky, J.A. (1991). Development of artificial vaccines against HIV using defined epitopes. FASEB L. 5, 2412-2418.
3. Broliden, P.A., Gegerfelt, A.V., Clapham, P., Rosen, J., Fenyo, E.M., Wahren, B., and Broliden, K. (1992). Identification of human neutralization-inducing regions of the human immunodeficiency virus type 1 envelope glycoproteins. Proc. Natl. Acad. Sci. USA 89, 461-465.
4. Burton, D.R., and Montefiori, D.C. (1997). The antibody response in HIV infection. AIDS 11, S87-98.
5. Burton, D.R., and Moore, J.P. (1998). Why do we not have an HIV vaccine and how can we make one? Nature Medicine 4, 495-498.
6. Casement, K.S., Nehete, P.N., Arlingaus, R.B., and Sastry, K.J. (1995). Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1. Virology 211, 261-267.
7. Chrystie, I.L., and Almeida, J.D. (1988). The morphology of human immunodeficiency virus (HIV) by negative staining. J. Med. Virol. 25, 281-288.
8. Dupraz, P., Oertle, S., Meric, C., Damay, P., and Spahr, P.F. (1990). Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein. J. Virol. 64, 4978-4987.
9. Ferrari, G., Humphrey, W., McElrath, M.J., Excler, J.-L., Duliege, A.-M., Clements, M.L., Corey, L.C., Bolognesi, D.P., and Weinhold, K.J. (1997). Clade B-based HIV-1 vaccines elicit crossclade cytotoxic T lymphocyte reactivities in uninfected volunteers. Proc. Natl. Acad. Sci. USA 94, 1396-1401.
10. Gelderblom, H.R., Hausmann, E.H.S., Ozel, M., Pauli, G., and Koch, M.A. (1987). Fine structure of human immunodeficiency virus (HIV) immunolocalization of structural proteins. Virology 156, 171-176.
11. gag virus-like particles from recombinant baculovirus-infected insect cells. Cell 59, 103-112.
12. Gorelick, R.J., Henderson, L.E., Hanser, J.P., and Rein, A. (1988). Point mutants of Moloney murine leukaemia virus that fail to package viral RNA: Evidence for specific RNA recognition by "zinc-finger-like" protein sequence. Proc. Natl. Acad. Sci. USA 85, 8420-8424.
13. Goudsmit, J., Debouck, C., Meloen, R.H., Smith, L., Bakker, M., Asher, D.M. Wolff, A.V., Gibbs, C.J., Jr., Gajdusek, D.C. (1988). Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees. Proc. Natl. Acad. Sci. USA 85, 4478-4482.
14. Hoshikawa, N., Kojima, A., Yasuda, A., Takayashiki, E., Musako, S., Chiba, J., Sata, T., and Kurata, T. (1991). Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: An ultrastructural study. J. Gen. Virol. 72, 2509-2517.
15. Jassoy, C., and Walker, B.D. (1997). HIV-1 specific cytotoxic T lymphocytes and the control of HIV-1 replication. Springer Semin Immunopathol 18, 341-354.
16. Jowett, J.B.M., Hockley, D.J., Nermut, M.V., and Jones, I.M. (1992). Distinct signals in HIV-1 Pr55 necessary for RNA binding and particle formation. J. Gen. Virol. 73, 3079-3086.
17. Klavinskis, L.S., Whitton, J.L., and Oldstone, M.B. (1989). Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. J. Virol. 63, 4311-4316.
18. LaRosa, G.J., Davide, J.P., Weinhold, K., Waterbury, J.A., Profy, A.T., Lewis, J.A. et al. (1990). Conserved sequence and structural elements in HIV-1 principal neutralizing determinant Science 249, 932-935.
19. LeBorgne, S., Mancini, M., LeGrand, R., Schleef, M., Dormont, D., Tiollais, P., Riviére, Y., and Michel, M.-L. (1998). In vivo induction of specific cytotoxic T lymphocytes in mice and Rhesus Macaques immunized with DNA vector encoding an HIV epitope fused with hepatitis B surface antigen, Virology 240, 304-315.
20. Li, Y., Luo, L., Rasool, N., and Kang, C.Y. (1993). Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding. J. Virol. 67, 534-588.
21. Li, Y., Luo, L., Thomas, D.Y., and Kang, C.Y. (1994). Control of expression, glycosylation, and secretion of HIV-1 gp120 by homologous and heterologous signal sequences. Virology 204, 266-278.
22. Luke, W., Voss, G., Stahl-Hening, C., Coulibaly, P.P., Petry, H., and Hunsmann, G. (1993). Protection of Cynomolgus Macaques (Macca fascicularis) against infection with the human immunodeficiency virus type 2 strain ben (HIV-2ben) by immunization with the virion-derived envelope glycoprotein gp130. AIDS Res. Hum. Retroviruses 9, 387-394.
23. mac32H grown on T cells or derived ex vivo. Virology 216, 444-450.
24. Luo, L., Li, Y., and Kang, C.Y. (1990). Expression of gag precursor protein and secretion of virus-like gag particles of HIV-2 from recombinant baculovirus-infected insect cells. Virology 179, 874-880.
25. Luo, L., Li, Y., Cannon, P.M., Kim, S., and Kang, C.Y. (1992). Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies. Proc. Natl. Acad. Sci. USA 89, 10527-10531.
26. Luo, L., Li, Y., Dales, S., and Kang, C.Y. (1994). Mapping of functional domains for HIV-2 gag assembly into virus-like particles. Virology 205, 469-502.
27. Luo, L., Li, Y., Chang, J-S., Cho, S-Y., Kim, T-Y., Choi, M-J. et al. (1998). Induction of V3 specific cytotoxic T lymphocyte responses by HIV gag particles carrying multiple immunodominant V3 epitopes of gp120. Virology 240, 316-325.
28. Myers, G. (1989). Human Retroviruses and AIDS (Los Alamos, NM, USA: Los Alamos National Laboratory), pp. 11-47.
29. Nara, P.L., Hatch, W.C., Dunlop, N.M., Robey, W.G., and Fischinger, P.J. (1987). Simple, rapid, quantitative, syncytiumforming microassay for the detection of human immunodeficiency virus neutralizing antibody. AIDS. Res. Hum. Retroviruses 3, 283-303.
30. Nara, P.L., Robey, W.G., Pyle, S.W., Hatch, W.C., Dunlop, N.M., Bess, J.W., Kelliher, J.C., Arthur, L.O., and Fischinger, P.J. (1988). Purified envelope glycoproteins from human immunodeficiency virus type 1 variants induce individual, type-specific neutralizing antibodies. J. Virol. 62, 2622-2628.
31. Oldstone, M.B. (1997). How viruses escape from cytotoxic T lymphocytes: molecular parameters and players. Virology 234, 179-185.
32. Papsidero, L.D., Sheu, M., and Ruscetti, F.W. (1989). Human immunodeficiency virus type 1 neutralizing monoclonal antibodies which react with p17 core protein: characterization and epitope mapping. J. Virol. 63, 267-272.
33. Poiesz, B.J., Ruscetti, F.W., Gazdar, A.F., Bunn, P.A., Minna, P.A., and Gallo, R.C. (1980). Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77, 7415-7419.
34. Prince, A.M., Horowitz, B., Baker, L., Shulman, R.W., Ralph, H. et al. (1988). Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV. Proc. Natl. Acad. Sci. USA 85, 6944-6948.
35. Prince, A.M., Reesink, H.P.D., Horowitz, B., Hewlett, I., Murthy, K.K., Cobb, K.E. et al. (1991). Prevention of HIV infection by passive immunization with HIV immunoglobin. AIDS. Res. Hum. Retroviruses 7, 971-973.
36. Rouse, B.T., Norley, S., and Martin, S. (1988). Antiviral cytotoxic T lymphocyte induction and vaccination. Rev. Infect. Dis. 10, 16-33.
37. Rowland-Jones, S., Tan, R., and McMichael, A. (1997). Role of cellular immunity in protection against HIV infection. Adv. Immunol. 65, 277-346.
38. Royer, M., Cerutti, M., Gay, B., Hong, S.S., Devauchelle, G., and Boulanger, P. (1991). Functional domains of HIV-1 Gag-polyprotein expressed in baculovirus-infected cells. Virology 184, 417-422.
39. Royer, M., Hong, S.S., Gay, B., Cerutti, M., and Boulanger, P. (1992). Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells. J. Virol. 66, 3230-3235.
40. Schupbach, J., Popovic, M., Gilden, R.V., Gonda, M.A., Sarngadharan, M.G., and Gallo, R.C. (1984). Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS. Science 224, 503-505.
41. Takahashi, H., Nakagawa, Y., Pendleton, C.D., Houghten, R.A., Yokomuro, K., Germain, R.N., and Berzofsky, J.A. (1992). Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science 255, 333-336.
42. Townsend, A.R., Rothbard, J., Gotch, F.M., Bahadur, G., Wraith, D., and McMichael, A.J. (1986). The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44, 959-968.
43. Wagner, R., Teeuwsen, V.J.P., Demi, L., Notka, F., Haaksma, A.G.M., Jhagjhoorsingh, S.S., Niphuis, H., Wolf, H., and Heeney, J.L. (1998). Cytotoxic T cells and neutralizing antibodies induced in Rhesus monkey by virus-like particle HIV vaccines in the absence of protection from SHIV infection. Virology 245, 65-74.
44. Weldon, R.A., Erdie, C.R., Oliver, M.G., and Wills, J.W. (1990). Incorporation of chimeric gag protein into retroviral particles. J. Virol. 64, 4169-4179
45. Williamson, M.P. (1994). The structure and function of proline-rich regions in proteins. Biochem. J. 297, 249-260.
46. Zhou, F., Rouse, B.T., and Huang, L. (1991). An improved method of loading pH-sensitive liposomes with soluble proteins for class I restricted antigen presentation. J. Immunol. Methods 145, 143-152.