Transduction of a preselected population of human epidermal stem cells: Consequences for gene therapy

Proceedings of the Association of American Physicians

Volumn 111, Issue 3, 1999, Pages 184-189

  Bickenbach, J R ^a   Roop, D R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Bioengineered tissue; Epidermolysis bullosa simplex (EBS); Keratin 14 (K14); Organotypic culture; Recombinant gene; Retrovirus

Indexed keywords

COLLAGEN TYPE 4; KERATIN;

CELL DIVISION; CELL PROLIFERATION; EPIDERMIS CELL; EPIDERMOLYSIS BULLOSA SIMPLEX; EPITHELIUM CELL; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; KERATINOCYTE; RECOMBINANT GENE; REVIEW; SKIN DISEASE; STEM CELL; TISSUE REGENERATION;

EID: 0032969257     PISSN: 1081650X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1381.1999.99222.x     Document Type: Review

References (44)

1. 1 Potten C.S. Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int. Rev. Cytol. 69: 271 318, 1981.
2. 2 Cairnie A.B., Lala P.K., Osmond D.U.G. In: Stem Cells of Renewing Cell Populations. New York: Academic Press, 1976.
3. 3 Potten C.S. In: Stem Cells. London: Academic Press, 1997.
4. 4 Cairns J. Mutation selection and the natural history of cancer. Nature 255: 197 200, 1975.
5. 5 Rothnagel J.A. & Roop D.R. Analysis, diagnosis, and molecular genetics of keratin disorders. Curr. Opin. Dermatol. 2: 211 218, 1995.
6. 6 Korge B.P. & Krieg T. The molecular basis for inherited bullous diseases. J. Mol. Med. 74: 59 70, 1996.
7. 7 Fuchs E. Of mice and men: Genetic disorders of the cytoskeleton. Mol. Biol. Cell 8: 189 203, 1997.
8. 8 Rothnagel J.A., Dominey A.M., Dempsey L.D., et al. Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. Science 257: 1128 1130, 1992.
9. 9 Christiano A.M., Greenspan D.S., Hoffman G.G., et al. Missense mutations in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa. Nat. Genet. 4: 62 66, 1993.
10. 10 Christiano A.M. & Uitto J. Molecular complexity of the cutaneous basement membrane zone. Revelations front the paradigms of epidermolysis bullosa. Exp. Dermatol. 5: 1 11, 1996.
11. 11 Pulkkinen L., Kimonis V.E., Xu Y., et al. Homozygous α6 integrin mutation in junctional epidermolysis bullosa with congenital duodenal atresia. Hum. Mol. Genet. 6: 669 674, 1997.
12. 12 Vidal F., Aberdam D., Miquel C., Christiano A.M. Integrin β4 mutations associated with epidermolysis bullosa with pyloric atresia. Nat. Genet. 10: 229 234, 1995.
13. 13 Kivirikko S., McGrath J.A., Pulkkinen L., et al. Mutational hotspots in the LAMB3 gene in the lethal (Herlitz) type of junctional epidermolysis bullosa. Hum. Mol. Genet. 2: 231 237, 1993.
14. 14 McGrath J.A., Gatalica B., Christiano A.M., et al. Mutations in the 180‐kD bullous pemphigoid antigen, a hemidesmosomal transmembrane collagen, in generalized atrophic benign epidermolysis bullosa. Nat. Genet. 11: 83 86, 1995.
15. 15 Huber M. & Hohl D. Mutations of keratinocyte transglutaminase in lamellar ichthyosis. Science 267: 525 528, 1995.
16. 16 Choate K.A., Medalie D.A., Morgan J.R., Khavari P.A. Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nat. Med. 2: 1263 1267, 1996.
17. 17 Halprin K.M. Epidermal turnover time—a re‐examination. Br. J. Dermatol. 86: 14 19, 1972.
18. 18 Blau H. & Khavari P. Gene therapy: progress, problems, prospects. Nat. Med. 3: 612 613, 1997.
19. 19 Bickenbach J.R. Identification of label‐retaining cells in oral mucosa and skin. J. Dent. Res. 122C: 1611 1620, 1981.
20. 20 Mackenzie I.C. & Bickenbach J.R. Label‐retaining keratinocytes and Langerhans cells in mouse epithelia. Cell Tissue Res. 242: 551 556, 1985.
21. 21 Jones P.H. & Watt F.M. Separation of human epidermal stem cells from transient amplifying cells on the basis of differences in integrin function and expression. Cell 73: 713 724, 1993.
22. 22 Jones P.H., Harper S., Watt F.M. Stem cell patterning and fate in human epidermis. Cell 80: 83 93, 1995.
23. 23 Bickenbach J.R. & Chism E. Selection and extended growth of murine epidermal stem cells in culture. Exp. Cell Res. 244: 184 195, 1998.
24. 24 Potten C.S. & Lord B.I. Stem Cells: Their Identification and Characterization. London: Churchill Livingstone, 1983.
25. 25 Barrandon Y. & Green H. Three types of keratinocytes with different capacities for multiplication. Proc. Natl. Acad. Sci. U.S.A. 84: 2302 2306, 1986.
26. 26 Degreef H.J. How to heal a wound fast. Dermatol. Clinics 16: 365 375, 1998.
27. 27 Rheinwald J.G. & Green H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell. 6: 331 344, 1975.
28. 28 Compton C.C., Gill J.M., Bradford D.A., et al. Skin regenerated from cultured epithelial autografts on full‐thickness burn wounds from 6 days to 5 years after grafting. Lab. Invest. 60: 600 612, 1989.
29. 29 Otto W.R., Nanchahal J., Lu Q.‐L.B., et al. Survival of allogeneic cells in cultured organotypic skin grafts. Surg. Plast. Reconstr. 96: 166 176, 1993.
30. 30 Mackenzie I.C. & Hill M.W. Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse. Cell Tissue Res. 235: 551 559, 1984.
31. 31 Mackenzie I.C., Rittman G., Bohnert A., et al. Influence of connective tissues on the in vitro growth and differentiation of murine epidermis. Epith. Cell Biol. 2: 107 119, 1993.
32. 32 Kraut J.D., Eckhardt A.J., Patton M.L., et al. Combined simultaneous application of cultured epithelial autografts and AlloDerm®. Wounds 7: 137 142, 1995.
33. 33 Garlick J.A., Katz A.B., Fenjves E.S., Taichman L.B. Retrovirus‐mediated transduction of cultured epidermal keratinocytes. J. Invest. Dermatol. 7: 824 829, 1991.
34. 34 Vogt P.M., Thompson S., Andree C., et al. Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis. Proc. Natl. Acad. Sci. U.S.A. 91: 9307 9311, 1994.
35. 35 Ng R.L.H., Woodward B., Bevan S., et al. Retroviral marking identifies grafted autologous keratinocytes in porcine wounds receiving cultured epithelium. J. Invest. Dermatol. 108: 457 462, 1997.
36. 36 Morgan J.R., Barrandon Y., Green H., Mulligan R.C. Expression of an exogenous growth hormone gene by transplantable human epidermal cells. Science 237: 1476 1479, 1987.
37. 37 Fenjives E.S., Yao S.‐N., Kurachi K., Taichman L.B. Loss of expression of a retrovirus‐transduced gene in human keratinocytes. J. Invest. Dermatol. 106: 576 578, 1996.
38. 38 Kamimura J., Lee D., Baden H.P., Brissette J., Dotto G.P. Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. J. Invest. Dermatol. 109: 534 540, 1997.
39. 39 Mackenzie I.C. Retroviral transduction of murine epidermal stem cells demonstrates clonal units of epidermal structure. J. Invest. Dermatol. 109: 377 383, 1997.
40. 40 Kolodka T.M., Garlick J.A., Taichman L.B. Evidence for keratinocyte stem cells in vitro: Long term engraftment and persistence of transgene expression from retrovirus‐transduced keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 95: 4356 4361, 1998.
41. 41 Miller D.G., Adam M.A., Miller D. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell Biol. 10: 4329 4342, 1990.
42. 42 Tani K., Lin T., Hibino H., et al. Transduction of LacZ gene into leukemia cells using viral vectors of retrovirus and adenovirus. Leukemia 9 (3): S64 ‐ 65, 1995.
43. 43 Paller A.S., Syder A.J., Chan Y.‐M., et al. Genetic and clinical mosaicism in a type of epidermal nevus. N. Engl. J. Med. 331: 1408 1415, 1994.
44. 44 Fuchs E., Chan Y.‐M., Paller A.S., Yu Q.‐C. Cracks in the foundation: Keratin filaments and genetic disease. Trends Cell Biol. 4: 321 326, 1994.