Gene therapy: Progress, problems, prospects

Nature Medicine

Volumn 3, Issue 6, 1997, Pages 612-613

  Blau, Helen ^a   Khavari, Paul ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD40 ANTIGEN; GENE PRODUCT; TUMOR VACCINE; VIRUS VECTOR;

ADENOVIRUS; CARDIOVASCULAR DISEASE; CYSTIC FIBROSIS; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; IMMUNE RESPONSE; IMMUNOGENICITY; INFLAMMATION; PRIORITY JOURNAL; SHORT SURVEY; TRANSGENE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADENOVIRIDAE; ANIMALS; CYSTIC FIBROSIS; GENE THERAPY; GENETIC VECTORS; HUMANS; NEOPLASMS;

EID: 0030948670     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0697-612     Document Type: Short Survey

References (8)

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3. Koeberl, D. D., Alexander, I. E., Halbert, C. L., Russell, D. W. & Miller, A. D. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. PNAS USA 94, 1426-1431 (1997).
4. Ilan, Y. et al. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. PNAS USA 94, 2587-2592 (1997).
5. Fasbender, A. et al. Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer In vitro and in vivo. J. Biol. Chem. 272, 6479-6489 (1997).
6. Naldini, L., Blomer, U., Cage, F. H., Trono, D. & Verma, I. M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. PNAS USA 93, 11382-11388 (1996).
7. Tinsley, J. M. et al. Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene. Nature 384, 349-353 (1996).
8. Bohl, D., Naffakh, N. & Heard, J. M. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nature Med. 3, 299-305 (1997).