Lipid signaling and cell responses at the nuclear level

Histology and Histopathology

Volumn 14, Issue 1, 1999, Pages 321-335

  Neri, L M ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Differentiation; Lipids; Nuclear matrix; Nucleus; Proliferation; Signaling

Indexed keywords

DOUBLE STRANDED DNA; LIPID; POLYPHOSPHOINOSITIDE; RNA;

CELL DIFFERENTIATION; CELL FUNCTION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CELL TRANSFORMATION; DNA REPAIR; DRUG RESISTANCE; HUMAN; LIPID METABOLISM; NONHUMAN; REVIEW; RNA SYNTHESIS; SIGNAL TRANSDUCTION; TOPOGRAPHY;

EID: 0032968360     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (157)

1. Albi E., Micheli M. and Viola Magni M.P. (1996). Phospholipids and nuclear RNA. Cell Biol. Int. 20, 407-412.
2. Albi E. and Viola Magni M.P. (1997). Chromatin neutral sphingomyelinase and its role in hepatic regeneration. Biochem. Biophys. Res. Commun. 236, 29-33.
3. Alessenko A. and Chatterjee S. (1995). Neutral sphingomyelinase: localization in rat liver nuclei and involvement in regeneration proliferation. Mol. Cell. Biochem. 143, 169-174.
4. Andjelkovic M., Alessi D.R., Meier R., Fernandez A., Lamb N.J., Freeh M., Kron P., Cohen P., Lucocq J.M. and Hemmings D.A. (1997). Role of translocation and function of protein kinase B. J. Biol. Chem. 272, 31515-31524.
5. Asano M., Tamiya-Koizumi K., Homma Y., Takenawa T., Nimura Y., Kojima K. and Yoshida S. (1994). Purification and characterization of nuclear phospholipase C specific for phosphoinositides. J. Biol. Chem. 269, 12360-12366.
6. Bae Y.S., Cantley L.G., Chen C.S., Kim S.R., Kwon K.S. and Rhee S.G. (1998). Activation of phospholipase C-y by phosphatidylinositol 3,4,5- trisphosphate. J. Biol. Chem. 273, 4465-4469.
7. Bahk Y.Y., Lee Y.H., Lee T.G., Seo J., Ryu S.H. and Suh P.-G. (1994). Two forms of phospholipase C-131 generated by alternative splicing. J. Biol. Chem. 269, 8240-8245.
8. Bahk Y.Y., Song H., Baek S.H., Park B.Y., Kim H., Ryu S.H. and Suh P.-G. (1998). Localization of two forms of phospholipase C-01, a and b, in C6Bu-1 cells. Biochim. Biophys. Acta 1389, 76-80.
9. Balboa M.A. and Insel P.A. (1995). Nuclear phospholipase D in Madin- Darby canine kidney cells. J. Biol. Chem. 270, 29843-29847.
10. Balboa M.A., Balsinde J., Dennis E.A. and Insel P.A. (1995). A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. J. Biol. Chem. 270, 11738-11740.
11. Baldassare J.J., Jarpe M.B., Alferes L. and Raben D.M. (1997). Nuclear translocation of RhoA mediates the mitogen-induced activation of phospholipase D involved in nuclear envelope signal transduction. J. Biol. Chem. 272, 4911-4914.
12. Banfic H., Zizak M., Divecha N. and Irvine R.F. (1993). Nuclear diacylglycerol is increased during cell proliferation in vivo. Biochem. J. 290, 633-636.
13. Berezney R., Mortillaro M.J., Ma H., Wei X. and Samarabandu J. (1995). The nuclear matrix: a structural milieu for genomic function. Int. Rev. Cytol. 162A, 1-65.
14. Bertagnolo V., Mazzoni M., Ricci D., Carini C., Neri L.M., Previati M. and Capitani S. (1995). Identification of PI-PLC 01, y1, and 81 in rat liver: subcellular distribution and relationship to inositol lipid nuclear signalling. Cell. Signal. 7, 669-678.
15. Bertagnolo V., Marchisio M., Capitani S. and Neri LM. (1997). Intranuclear translocation of phospholipase C 02 during HL-60 myeloid differentiation. Biochem. Biophys. Res. Commun. 235, 831-837.
16. Billi A.M., Cocco L., Martelli A.M., Gilmour R.S. and Weber G. (1993). Tiazofurin-induced changes in inositol lipid cycle in nuclei of Friend erythroleukemia cells. Biochem. Biophys. Res. Commun. 195, 8-12.
17. Billi A.M., Matteucci A., Faenza I., Manzoli L., Rubbini S., Gilmour R.S., Rhee S.G. and Cocco L. (1997). Control of expression of PLC 01 by LAC repressor system: relationship between nuclear PLC 01 overexpression and growth factor stimulation. Biochem. Biophys. Res. Commun. 241,122-126.
18. Brock T.G., McNish R.W., Bailie M.B. and Peters-Golden M. (1997). Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J. Biol. Chem. 272, 8276-8280.
19. Capitani S., Cocco L., Maraldi N.M., Papa S. and Manzoli F.A. (1986). Effect of phospholipids on transcription and ribonucleoprotein processing in isolated nuclei. Advan. Enzyme Regul. 25, 425-438.
20. Capitani S., Bertagnolo V., Mazzoni M., Santi P., Previati M., Antonucci A. and Manzoli F.A. (1989). Lipid phosphorylation in isolated rat liver nuclei. FEBS Lett. 254, 194-198.
21. Capitani S., Helms B., Mazzoni M., Previati P., Bertagnolo V., Wirtz K.W.A. and Manzoli F.A. (1990). Uptake and phosphorylation of phosphatidylinositol in rat liver nuclei: role of phosphatidylinositol transfer protein. Biochim. Biophys. Acta 1044, 189-200.
22. Capitani S., Billi A.M., Bertagnolo V., Previati M., Mazzoni M., Neri L.M. and Manzoli F.A. (1991). Inositol lipids in Friend erythroleukemia cells: evidence for changes in nuclear metabolism after differentiation. Cell Biochem. Funct. 9, 135-145.
23. Capriotti A.M., Furth E.E., Arrasmith M.E. and Laposata M. (1988). Arachidonate released upon agonist stimulation preferentially originates from arachidonate most recently incorporated into nuclear membrane phospholipids. J. Biol. Chem 263, 10029-10034.
24. Caramelli E., Matteucci A., Zini N., Carini C., Guidotti L., Ricci D., Maraldi N.M. and Capitani S. (1996). Nuclear phosphoinositide- specific phospholipase C, phosphatidylinositol 4,5-bisphosphate and protein kinase C during rat spermatogenesis. Eur. J. Cell Biol. 71, 154-164.
25. Carpenter C.L. and Cantley L.C. (1996). Phosphoinositide 3-kinase and the regulation of cell growth. Biochim. Biophys. Acta 1288, 11-16.
26. Catalan R.E., Calcerrada M.C., Miguel B.G. and Martinez A.M. (1997a). Mechanisms or arachidonic acid-induced Ca++ mobilization in liver nuclei. J. Lipid Mediat. Cell Signal. 17, 167-174.
27. Catalan R.E., Miguel B.G., Calcerrada M.C., Ruiz S. and Martinez A.M. (1997b). Sphingolipids increase calcium concentration in isolated rat liver nuclei. Biochem. Biophys. Res. Commun. 238, 347-350.
28. Cataldi A., Miscia S., Lisio R., Rana R. and Cocco L. (1990). Transient shift of diacylglycerol and inositol lipids induced by interferon in Daudi cells. Evidence for a different pattern between nuclei and intact cells. FEBS Lett. 269, 465-468.
29. Cataldi A., Rana R., Bareggi R., Lisio R., Robuffo I., Di Valerio V. and Miscia S. (1993a). Evidence for nuclear phosphoinositidase C activity in the antiproliferative signals produced by interferon in Burkitt lymphoma cells. Cytokine 5, 235-239.
30. Cataldi A., Di Primio R., Lisio R., Rana R., Robuffo I., Bosco D. and Miscia S. (1993b). Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon a-sensitive and -resistant Daudi lymphoma cells. Cell. Signal. 5, 331-336.
31. Cataldi A., Di Pietro R., Robuffo I., Di Baldassarre A. and Miscia S. (1994a). Nuclear phosphoinositide signalling enzymes in human B lymphoid cells. Cell Struct. Funct. 19, 375-384.
32. Cataldi A., Lisio R., Robuffo I., Di Baldassarre A., Di Valerio V. and Miscia S. (1994b). Interferon mediated phosphatidylinositol uptake and processing in nuclei isolated from Burkitt lymphoma cells. Cell. Signal. 6, 657-662.
33. Cataldi A., Di Pietro R., Antonucci A., Di Baldassarre A. and Miscia S. (1995a). Phosphoinositidase C 01 isoform expression is modulated by interferon a in Burkitt lymphoma cells. Cell. Signal. 7, 105-112.
34. Cataldi A., Rana R., Caracino A., Di Baldassarre A., Robuffo I. and Miscia S. (1995b). Phosphoinositide signalling enzymes in human T lymphocytes: modulation of phosphoinositidase C isoform y1 upon interferon treatment. Cell Struct. Funct. 20, 143-149.
35. Chapkin R.S., Davidson L.D. and Davidson L.A. (1992). Phospholipid molecular species composition of mouse liver nuclei. Influence of dietary n-3 fatty acid ethyl esters. Biochem. J. 287, 237-240.
36. Clark J.M., Hodgkin M.N. and Wakelam M.J. (1997). HL 60 nuclei lacking the nuclear double membrane contain a PLD activity which is insensitive to the ADP-ribosylation factor. Biochem. Soc. Trans. 25, S590.
37. Cocco L., Gilmour R.S., Ognibene A., Manzoli F.A. and Irvine R.F. (1987a). Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for phosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem. J. 248, 765-770.
38. Cocco L., Martelli A.M., Billi A.M., Cataldi A., Miscia S., Mottola M.R and Manzoli L. (1987b). Phospholipids as components of the nuclear matrix: their possible biological significance. Basic Appl. Histochem. 31, 413-419.
39. Cocco L., Martelli A.M., Gilmour R.S., Ognibene A., Manzoli F.A. and Irvine R.F. (1988). Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I. Biochem. Biophys. Res. Commun. 154, 1266-1278.
40. Cocco L., Martelli A.M., Gilmour R.S., Ognibene A., Manzoli F.A. and Irvine R.F. (1989). Changes in nuclear inositol lipids induced in intact cells by IGF-I. Biochem. Biophys. Res. Commun. 159, 720-725.
41. Cocco L., Martelli A.M. and Gilmour R.S. (1994). Inositol lipid cycle in the nucleus. Cell. Signal. 6, 481-485.
42. Cockroft S. (1997). Phosphatidylinositol transfer protein: requirements in phospholipase C signaling and in regulated exocytosis. FEBS Lett. 410, 44-48.
43. Collins S. (1987). The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70, 1233-1244.
44. Crouch M.F. (1991). Growth factor-induced cell division is paralleled by translocation of Gict to the nucleus. FASEB J. 5, 200-206.
45. de Vries K.J., Westerman J, Bastiaens P.I.H., Jovin T.M., Wirtz K.W.A. and Snoek T. (1996). Fluorescently labelled phosphatidylinositol- transfer protein isoforms (a) and (3), microinjected into foetal bovine heart endothelial cells, are targeted to distinct intracellular sites. Exp. Cell Res. 227, 33-39.
46. Diakonova M., Chilov D., Arnaoutov A., Alexeyev V., Nikolski N. and Medvedeva N. (1997). Intracellular distribution of phospholipase C Y1 in cell lines with different levels of transformation. Eur. J. Cell Biol. 73, 360-367.
47. Divecha N. and Irvine R.F. (1995). Phospholipid signalling. Cell 80, 269-278.
48. Divecha N., Banfic H. and Irvine R.F. (1991). The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J. 10, 3207-3214.
49. Divecha N., Rhee S.G., Letcher A.J. and Irvine R.F. (1993). Phospho-inositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform 81 is specifically, but not predominantly, located in the nucleus. Biochem. J. 289, 617-620.
50. Divecha N., Letcher A.J., Banfic H.H., Rhee S.G. and Irvine R.F. (1995). Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells. Biochem. J. 312, 63-67.
51. Exton J.H. (1994). Messenger molecules derived from membrane lipids. Curr. Opin. Cell Biol. 6, 226-229.
52. Exton J.H. (1997). New developments in phospholipase D. J. Biol. Chem. 272, 15579-15582.
53. Fee J.A., Monsey J.D., Handler R.J., Leonis M.A., Mullaney S R., Hope H M. and Silbert D.F. (1994). A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-131. J. Biol. Chem. 269, 21699-21708.
54. Freeman E.J., Ruehr M.L and Dorman R.V. (1998). ANG ll-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells. Am. J. Physiol. 274, 282-288.
55. Friedman E.A. and Schildkraut C.K. (1977). Terminal differentiation in cultured Friend erythroleukemia cells. Cell 12, 901-913.
56. Hansonn A. and Thoren M. (1995). Activation of MAP kinase in Swiss 3T3 fibroblasts by insulin-like growth factor-l. Growth Regul 5, 92-100.
57. Humbert J.P., Matter N., Artault J.C., Koppler P. and Maviya A.N. (1995). Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear membranes. J. Biol. Chem. 271, 478-485.
58. Ishihara H., Tamiya-Koizumi K., Kuriki H., Yoshida S. and Kojima K. (1991). Growth-associated changes in fatty acid compositions of nuclear phospholipids of liver cells. Biochem. Biophys. Acta 1084, 53-59.
59. Jarpe M.B., Leach K.L. and Raben D.M. (1994). A-thrombin-associated nuclear sn-1,2-diacylglycerols are derived from phosphatidylcholine hydrolysis in cultured fibroblasts. Biochemistry 33, 526-534.
60. Kanfer J.N., McCartney D.G., Singh I.N. and Freysz L. (1996). Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei. FEBS Lett. 383, 6-8.
61. Kim C.G., Park D. and Rhee S.G. (1996). The role of carboxyl-terminal basic amino acids in the Gqa-dependent activation, particulate association, and nuclear localization of phospholipase C-B1. J. Biol. Chem. 271, 21187-21192.
62. Kim S.J. and Kahn C.R. (1997). Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression. Biochem J. 323, 621-627.
63. Koppler P., Matter N. and Malviya A.N. (1993). Evidence for stereo- specific inositol 1,3,4,5-[3H]tetrakisphosphate binding sites on rat liver nuclei. Delineating inositol 1,3,4,5-tetrakisphosphate interaction in nuclear calcium signaling process. J. Biol. Chem. 268, 26248-26252.
64. Koppler P., Mersel M., Humbert J.P., Vignon J., Vincendon G. and Malviya A.N. (1996). High affinity inositol 1,3,4,5-tetrakisphosphate receptor from rat liver nuclei: purification, characterization, and amino-terminal sequence. Biochemistry 35, 5481-5487.
65. Kuriki H., Tamiya-Koizumi K., Asano M., Yoshida S., Kojima K. and Nimura Y. (1992). Existence of phosphoinositide-specific phospholipase C in rat liver nuclei and its changes during liver regeneration. J. Biochem. 111, 283-286.
66. Leach K.L., Ruff V.A., Jarpe M.B., Adams L.D., Fabbro D. and Raben D.M. (1992). A-thrombin stimulates nuclear diglyceride kinase levels and differential nuclear localization of protein kinase C isozymes in IIC9 cells. J. Biol. Chem. 267, 21816-21822.
67. Lee S.B. and Rhee S.G. (1995). Significance of PIP2 hydrolysis and regulation of phospholipase C enzymes. Curr. Opin. Cell Biol. 7, 183-189.
68. Lee J.Y., Hannun Y.A. and Obeid L.M. (1996). Ceramide inactivates cellular protein kinase C-cx. J. Biol. Chem. 271, 13169-13174.
69. Levi Montalcini R. (1987). The nerve growth factor, thirty-five years later. EMBO J. 6, 1145-1154.
70. Liscovitch M. and Cantley L.C. (1994). Lipid second messengers. Cell 77, 329-334.
71. Liu N., Fukami K., Yu H. and Takenawa T. (1996). A new phospholipase C 64 is induced at S-phase of the cell cycle and appears in the nucleus. J. Biol. Chem. 271, 355-360.
72. Lu P.J., Hsu A.L., Wang D.S., Yan H.Y., Yin H.L. and Chen C.S. (1998). Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry 37, 5738-5745.
73. Mallia C.M., Smith M., Clejan S. and Beckman B.S. (1997). Erythropoietin stimulates nuclear localization of diacylglycerol and protein kinase C-BII in B6Eut.Ep cells. J. Lipid Mediat, Cell Signal. 17, 135-150.
74. Malviya A.N., Rogue P. and Vincendon G. (1990). Stereospecific inositol 1,4,5- [32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus. Proc. Natl. Acad. Sci. USA 87, 9270-9274.
75. Malviya A.N. (1994). The nuclear inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate receptors. Cell Calcium 16, 301-313.
76. Manzoli F.A., Muchmore J.H., Bonora B., Capitani S. and Bartoli S. (1974). Lipid-DNA interactions. Phospholipids, cholesterol, glycero- phosphocholine, sphingosine and fatty acids. Biochim. Biophys. Acta 34, 1-15.
77. Manzoli L., Billi A.M., Gilmour R.S., Martelli A.M., Matteucci A., Rubbini S., Weber G. and Cocco L. (1995). Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C β1. Cancer Res. 55, 2978-2980.
78. Manzoli L., Billi A.M., Rubbini S., Bavelloni A., Faenza I., Gilmour R. S., Rhee S.-G. and Cocco L. (1997). Essential role for nuclear phospho-lipase C 81 in insulin-like growth factor l-induced mitogenesis. Cancer Res. 57, 2137-2139.
79. Maraldi N.M., Mazzotti G., Capitani S., Rizzzoli R., Zini N., Squarzoni S. and Manzoli F.A. (1992a). Morphological evidence of function- related localization of phospholipids in the cell nucleus. Adv. Enzyme Regul. 32, 73-90.
80. Maraldi N.M., Zini N., Squarzoni S., Del Coco R., Sabatelli P. and Manzoli F.A. (1992b). Intranuclear localization of phospholipids by ultrastructural cytochemistry. J. Histochem. Cytochem. 40, 1383-1392.
81. Maraldi N.M., Zini N., Santi S., Bavelloni A., Valmori A., Marmiroli S. and Ognibene A. (1993a). Phosphoinositidase C isozymes in Saos-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments. Biol. Cell 79, 243-250.
82. Maraldi N.M., Santi S., Zini N., Ognibene A., Rizzoli R., Mazzotti G., Di Primio R., Bareggi R., Bertagnolo V., Pagliarini C. and Capitani S. (1993b). Decrease in nuclear phospholipids associated with DNA replication. J. Cell Sci. 104, 853-859.
83. Maraldi N.M., Zini N., Ognibene A., Martelli A.M., Barbieri M., Mazzotti G. and Manzoli F.A. (1995). Immunocytochemical detection of the intranuclear variations of phosphatidylinositol 4,5-bisphosphate amount associated with changes of activity and amount of phospholipase C 81 in cells exposed to mitogenic or differentiating agonists. Biol. Cell 83, 201-210.
84. Marmiroli S., Ognibene A., Bavelloni A., Cinti C., Cocco L. and Maraldi N.M. (1994). Interleukin 1a stimulates nuclear phospholipase C in human osteosarcoma Saos-2 cells. J. Biol. Chem. 269 13-16.
85. Marmiroli S., Zini N., Bavelloni A., Faenza I., Ognibene A. and Maraldi N.M. (1995). Transfected Saos-2 cells overexpressing phosphoinositidase C 81 isoform accumulate it within the nucleus. Biol. Cell 86, 121-126.
86. Martelli A M., Neri L.M., Gilmour R.S., Barker P.J., Huskisson N.S., Manzoli F.A. and Cocco L. (1991a). Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides. Biochem. Biophys. Res. Commun. 177, 480-487.
87. Martelli A.M., Gilmour R.S., Neri L.M., Manzoli L., Corps A.N. and Cocco L. (1991b). Mitogen stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein kinase C requirement and the onset of DNA synthesis. FEBS Lett. 283, 243-246.
88. Martelli A.M., Gilmour R.S., Bertagnolo V., Neri L. M., Manzoli L. and Cocco L. (1992). Nuclear localisation and signalling activity of phosphoinositidase C 81 in Swiss 3T3 cells. Nature 358, 242-245.
89. Martelli A.M., Billi A.M., Gilmour R.S., Neri L.M., Manzoli L., Ognibene A. and Cocco L. (1994). Phosphoinositide signaling in nuclei of Friend cells: phospholipase C down-regulation is related to cell differentiation. Cancer Res. 54, 2536-2540.
90. Martelli A.M., Cataldi A., Manzoli L., Billi A.M., Rubbini S., Gilmour R.S. and Cocco L. (1995). Inositides in nuclei of Friend cells: changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation. Cell. Signal. 7, 53-56.
91. Martelli A.M., Cocco L., Riederer B.M. and Neri L.M. (1996a). The nuclear matrix: a critical appraisal. Histol. Histopathol. 11, 1035-1048.
92. Martelli A.M., Bareggi R., Cocco L. and Manzoli F.A. (1996b). Stimulation of nuclear polyphosphoinositide synthesis by GTPy-S. A potential regulatory role for nuclear GTP-binding proteins. Biochem. Biophys. Res. Commun. 218, 182-186.
93. Matsumoto K., Morita I. and Murota S. (1994). Arachidonic acid metabolism by nuclei of a retinoic acid- or vitamin D3-differentiated human leukemia cell line HL-60. Prostaglandins Leukot. Essent. Fatty Acids 51, 51-55.
94. Matter N., Ritz M.F., Freyermuth S., Rogue P. and Malviya A.N. (1993). Stimulation of nuclear protein kinase C leads to phosphorylation of nuclear inositol 1,4,5-trisphosphate receptor and accelerated calcium release by inositol 1,4,5-trisphosphate from isolated rat liver nuclei. J. Biol. Chem. 268, 732-736.
95. Mazzoni M., Bertagnolo V., Neri L.M., Carini C., Milani D., Marchisio M., Manzoli F.A. and Capitani S. (1992). Discrete subcellular localization of phosphoinositidase C 8, y, and 5 in PC12 rat pheochromocytoma cells. Biochem. Biophys. Res. Commun. 187, 114-120.
96. Mazzotti G., Zini N., Rizzi E., Rizzoli R., Galanzi A., Ognibene A., Santi S., Matteucci A., Martelli A.M. and Maraldi N.M. (1995). Immuno-cytochemical detection of phosphatidylinositol 4,5-bisphosphate localization sites within the nucleus. J. Histochem. Cytochem. 43, 181-191.
97. Meier R., Alessi D.R., Cron P., Andjelkovic M. and Hemmings B.A. (1995). Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase B8. J. Biol. Chem. 272, 30491-30497.
98. Miscia S., Cataldi A., Ognibene A., Martelli A.M., Manzoli L., Billi A.M., De Marchis C. and Cocco L. (1988). Evidence for a reduction of the replicative activity of matrix-bound DNA polymerase following treatment with phospholipase C. Cell Biol. Int. Rep. 12, 347-354.
99. Miscia S., Cataldi A. and Grimley P.M. (1990). Early modifications of nucleic acid metabolism and nuclear lipid biosynthesis associated with antiproliferative activity of interferon-a on Daudi lymphoma cells. Exp. Cell Res. 187, 197-202.
100. Miscia S., Cataldi A., Lisio R., Tulipano G., Rizzoli R., Rana R. and Cocco L. (1991). Interferon transiently modulates intranuclear signalling system in erythroleukemia Friend cells. Cell Biol. Int. Rep. 15, 427-435.
101. Murray N.R. and Fields A.P. (1998). Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C. J. Biol. Chem. 273, 11514-11520.
102. Nakanishi H.: Brewer K.A. and Exton J.H. (1993). Activation of the -5 isozyme of protein kinase C by phosphatidylinositol 3,4,5- trisphosphate. J. Biol Chem. 268, 13-16.
103. Neitcheva T. and Peeva D. (1995). Phospholipid composition, phospholipase A2 and sphingomyelinase activities in rat liver nuclear membrane and matrix. Int. J. Biochem. Cell Biol. 27, 995-1001.
104. Neri L.M., Milani D., Marchisio M., Bertolaso L., Marinelli F., Manzoli F.A. and Capitani S. (1993). Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the 8 isoform during neural differentiation. Histochemistry 100, 121-129.
105. Neri L.M, Milani D., Bertolaso L., Stroscio M., Bertagnolo V. and Capitani S. (1994). Nuclear translocation of phosphatidylinositol 3- kinase in rat pheochromocytoma PC12 cells after treatment with nerve growth factor. Cell. Mol. Biol. 40, 619-626.
106. Neri L.M., Ricci D., Carini C., Marchisio M., Capitani S and Bertagnolo V. (1997). Changes of nuclear PI-PLC v1 during rat liver regeneration. Cell. Signal. 9, 353-362.
107. Neri L.M., Borgatti P., Capitani S. and Martelli A.M. (1998). Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-a. J. Biol. Chem. 273, 29738-29744.
108. Neufeld E.J., Majerus P.W., Krueger C.M. and Saffitz J.E. (1985). Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography. J. Cell Biol. 101, 573-581.
109. Nishizuka Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
110. Olah E., Natsumeda Y., Ikegami T., Kote Z., Horanyi M., Szelenyi J., Paulik E., Kremoler T., Hollan S.R., Sugar J. and Weber G. (1988). Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells. Proc. Natl. Acad. Sci. USA 85, 6533-6537.
111. Payrastre B., Nievers M., Boonstra J., Breton M., Verkleij A.J. and van Bergen-Henegouwen P.M.P. (1992). A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix. J. Biol. Chem. 267, 5078-5084.
112. Pettitt T.R., Martin A., Horton T., Liossis C., Lord J.M. and Wakelam M.J. (1997). Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells. J. Biol. Chem. 272, 17354-17359.
113. Previati M., Bertagnolo V., Mazzoni F., Osti F., Borgatti P. and Capitani S. (1994). Diacylglycerol kinase activity in rat liver nuclei. Cell. Signal. 6, 393-403.
114. Raben D.M., Jarpe M.B. and Leach K.L. (1994). Nuclear lipid metabolism in NEST: nuclear envelope signal transduction. J. Membrane Biol. 142, 1-7.
115. Rana R., Cataldi A., Di Pietro R., Mazzotti G., Centurione L., Robuffo I., Vitale M, and Miscia S. (1994). Evidence for an early and transient involvement of nuclear inositol lipids in subcellular signalling events related to DNA repair processes. Cell. Signal. 6, 475-480
116. Rhee S.G. and Bae Y.S. (1997). Regulation of phosphoinositide-specific phospholipase C isozymes. J. Biol. Chem. 272, 15045-15048.
117. Rosenberger U., Shakibaei M. and Buchner K. (1995). Localization of non-conventional protein kinase C isoforms in bovine brain cell nuclei. Biochem. J. 305, 269-275.
118. Rozengurt E. (1986). Early signals in mitogenic response. Science 234, 161-166.
119. Rubbini S., Cocco L., Manzoli L., Luttermann J., Billi A.M., Matteucci A. and Wirtz K.W.A. (1997). Phosphoinositide signalling in nuclei of Friend cells: DMSO-induced differentiation reduces the association of phosphatidylinositol-transfer protein with the nucleus. Biochem. Biophys. Res. Commun. 230, 302-305.
120. Saffitz J.E., Nash J.A., Green K.G., Luke R.A., Ransnas L.A. and Insel P.A. (1994). Immunoelectron microscopic identification of cyto¬plasmic and nuclear Gs in S49 lymphoma cells. FASEB J. 8, 252-258.
121. Santella L. and Carafoli E. (1997). Calcium signaling in the cell nucleus. FASEB J. 11, 1091-1109.
122. Santi P., Martelli A.M., Gilmour R.S., Falcieri E., Rana R., Cataldi A., Lattanzi G., Bareggi R. and Cocco L. (1992). Changes in polyphosphoinositide levels in rat liver nuclei in response to prolactin, a known hepatic mitogen. Cell. Signal. 4, 385-391.
123. Santi P., Marmiroli S., Falcieri E., Bertagnolo V. and Capitani S. (1994). Inositol lipid phosphorylation and breakdown in rat liver nuclei is affected by hydrocortisone blood levels. Cell Biochem. Funct. 12, 201-207.
124. Skinner M.K. (1991). Cell-cell interactions in the testis. Endocr. Rev. 12, 45-54.
125. Sierra-Honigmann M.R., Bradley J.R. and Pober J.S. (1996). “Cytosolic” phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation. Lab. Invest. 74, 684-695.
126. Smith C.D. and Wells W.W. (1983). Phophorylation of rat liver nuclear envelopes. II. Characterization of in vitro lipid phosphorylation. J. Biol. Chem. 258, 9368-9373.
127. Sun B., Murray N.R. and Fields A.P. (1997). A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition. J. Biol. Chem. 272, 26313-26317.
128. Surette M.E. and Chilton F.H. (1998). The distribution and metabolism of arachidonate-containing phospholipids in cellular nuclei. Biochem. J. 330, 915-921.
129. Sylvia V.L., Joe C O., Norman J.O., Curtin G.M. and Busbee D.L. (1986a). Phosphatidylinositol-dependent activation of DNA polymerase a. Biochem. Biophys. Res. Commun. 135, 880-885.
130. Sylvia V.L., Norman J.O., Curtin G.M. and Busbee D.L. (1986b). Monoclonal antibody that blocks phosphoinositide-dependent activation of mouse tumor DNA polymerase a. Biochem. Biophys. Res. Commun. 141, 60-66.
131. Sylvia V.L., Curtin G.M., Norman J.O., Stec J. and Busbee D.L. (1988). Activation of a low specific activity form of DNA polymerase a by inositol-1 -4-bisphosphate. Cell 54, 651-658.
132. Tamiya-Koizumi K., Umekawa H., Yoshida S., Ishihara H. and Kojima K. (1989a). A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulaiion of the Ca2+ dependency by polyphosphoinositides. Biochim. Biophys. Acta 1002, 182-188.
133. Tamiya-Koizumi K, Umekawa H., Yoshida S. and Kojima K. (1989b). Existence of Mg2+-dependent, neutral sphingomyelinase in nuclei of rat ascites hepatoma cells. J. Biochem. 106, 593-598.
134. Testi R. (1996). Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 21, 468-471.
135. Thomas G.M.H., Cunningham E., Fensome A., Ball A., Totty N.F., Truong O., Hsuan J. J. and Cockroft S. (1993). An essential role for phosphatidylinositol-transfer protein in phospholipase C-mediated inositol lipid signaling. Cell 74, 919-928.
136. Tran D., Gassard P., Berthon B., Fukami K., Takenawa T., Giraud F. and Claret M. (1993). Cellular distribution of polyphosphoinositides in rat hepatocytes. Cell. Signal. 5, 565-576.
137. Trubiani O., Martelli A.M., Manzoli L., Santavenere E. and Cocco L. (1990). Nuclear lipids in Friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO. Cell Biol. Int. Rep. 14, 559-566.
138. Trubiani O., Cataldi A., Rapino M., Bollum F. J. and Di Primio R. (1993). Phorbol ester induces changes in the synthesis of nuclear poly-phosphoinositides and expression of terminal deoxynucleotidyl transferase (TdT) in nuclei of KM-3 cells Biochem. Mol. Biol. Int. 29, 1123-1130.
139. Vann L.R., Wooding F.B.P., Irvine R.F. and Divecha N. (1997). Metabolism and possible compartmentalization of inositols lipids in isolated rat liver nuclei. Biochem. J. 327, 569-576.
140. Ves-Losada A. and Brenner R.R. (1995). Fatty acid 5 desaturation in rat liver cell nuclei. Mol. Cell. Biochem. 142, 163-170.
141. Wang Y., Sweitzer T.D., Weinhold P.A. and Kent C. (1993). Nuclear localization of soluble CTP: phosphocholine cytidyltransferase, J. Biol. Chem. 268, 5899-5904.
142. Wirtz K.W.A. (1991). Phospholipid transfer proteins. Annu. Rev. Biochem. 60, 73-99.
143. Woods J.W., Evans J.F., Ethier D., Scott S., Dickers P.J., Hearn L., Heibein J.A., Charleson S. and Singer H. (1993). 5-lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178, 1935-1946.
144. Woods J.W., Coffey M.J., Brock T.G., Siger H, and Peters-Golden M. (1995). 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Invest. 95, 2035-2046.
145. York J.D. and Majerus P.W. (1994). Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. J. Biol. Chem. 269, 7847-7850.
146. York J.D., Saffitz J.E. and Majerus P.W. (1994). Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. J. Biol. Chem. 269, 19992-19999.
147. Yu H., Fukami K., Watanabe Y., Ozaki C. and Takenawa T. (1998). Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1. Eur. J. Biochem. 251, 281-287.
148. Zauli G., Previati M., Caramelli E., Bassini A., Falcieri E., Gibellini D., Bertolaso L., Bosco D., Robuffo I. and Capitani S. (1995). Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. Eur. J. Immunol. 25, 2695-2700.
149. Zauli G., Visani G., Bassini A., Caramelli E., Ottaviani E., Bertolaso L., Bertagnolo V., Borgatti P. and Capitani S. (1996). Nuclear trans¬location of protein kinase C-a and -t, isoforms in HL-60 cells induced to differentiate along the granulocytic lineage by all-trans-retinoic acid. Br. J. Haematol. 93, 542-550.
150. Zhou G., Seibenhener M.L. and Wooten M. W. (1997). Nucleolin is a protein kinase C-i; substrate. Connection between cell surface signaling and nucleus in PC12 cells. J. Biol. Chem. 272, 31130-31137.
151. Zini N., Maraldi N.M., Martelli A.M., Antonucci A., Santi P., Mazzotti G., Rizzoli R. and Manzoli F.A. (1989). Phospholipase C digestion induces the removal of nuclear RNA. A cytochemical quantitative study. Histochem. J. 21, 491-499.
152. Zini N., Martelli A.M., Cocco L., Manzoli F.A. and Maraldi N.M. (1993). Phosphoinositidase C isoforms are specifically localized in the nuclear matrix and cytoskeleton of Swiss 3T3 cells. Exp. Cell Res. 208: 257-269.
153. Zini N., Mazzoni M., Neri L.M., Bavelloni A., Marmiroli S., Capitani S. and Maraldi N.M. (1994). Immunocytochemical detection of the specific association of different PIC isoforms with cytoskeletal and nuclear matrix compartments in PC12 cells. Eur. J. Cell Biol. 65, 206-213.
154. Zini N., Ognibene A., Marmiroli S., Bavelloni A., Maltarello M.C., Faenza I., Valmori A. and Maraldi N.M. (1995). The intranuclear amount of phospholipase C β1 decreases following cell differentiation in Friend cells, whereas 1 isoform is not affected. Eur. J. Cell Biol. 68, 25-34.
155. Zini N., Sabatelli P., Faenza I., Ognibene A. and Maraldi N. M. (1996a). Interleukin-α1 induces variations of the intranuclear amount of phosphatidylinositol 4,5-bisphosphate and phospholipase C β1 in human osteosarcoma Saos-2 cells. Histochem. J. 28, 495-504.
156. Zini N., Ognibene A., Bavelloni A., Santi S., Sabatelli P., Baldini N., Scotlandi K., Serra M. and Maraldi N. M. (1996b). Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells. Histochem. Cell Biol. 106, 457-464.
157. Zini N., Neri L. M., Ognibene A., Scotlandi K., Baldini N. and Maraldi N. M. (1997). Increase of nuclear phosphatidylinositol 4,5-bisphosphate and phospholipase C β1 is not associated to variations of protein kinase C in multidrug-resistant Saos-2 cells. Microsc. Res. Tech. 36, 172-178.