Expression, secretion, and inhibition of angiotensin-converting enzyme in cultured human bronchial epithelial cells

European Journal of Pharmacology

Volumn 370, Issue 2, 1999, Pages 169-177

  Takimoto, Misato ^a   Mitani, Hironobu ^a   Hori, Seiji ^a   Kimura, Masaaki ^a   Bandoh, Tsutomu ^a   Okada, Toshikazu ^a  

^a NOVARTIS PHARMA K K   (Japan)

Author keywords

Airway; Angiotensin II; Angiotensin converting enzyme; Bradykinin; Bronchial epithelial cell

Indexed keywords

ANGIOTENSIN; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; IMIDAPRILAT;

AGAR GEL ELECTROPHORESIS; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CONTROLLED STUDY; COUGHING; ESSENTIAL HYPERTENSION; HEART FAILURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; BRADYKININ; BRONCHI; CELLS, CULTURED; DRUG INTERACTIONS; ENALAPRILAT; EPITHELIAL CELLS; HUMANS; PEPTIDYL-DIPEPTIDASE A; RECEPTORS, ANGIOTENSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLES; VALINE;

EID: 0032968015     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00116-8     Document Type: Article

References (36)

1. Bhoola K.D., Figueroa C.D., Worthy K. Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol. Rev. 44:1992;1-80.
2. Bramley A.M., Samhoun M.N., Piper P.J. The role of the epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro. Br. J. Pharmacol. 99:1990;762-766.
3. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
4. Costerousse O., Allegrini J., Clozel J.-P., Menard J., Alhenc-Gelas F. Angiotensin I-converting enzyme inhibition but not angiotensin II suppression alters angiotensin I-converting enzyme gene expression in vessels and epithelia. J. Pharmacol. Exp. Ther. 284:1998;1180-1187.
5. 1-receptor subtype. Br. J. Pharmacol. 110:1993;761-771.
6. Denning G.M., Welsh M.J. Polarized distribution of bradykinin receptors on airway epithelial cells and independent coupling to second messenger pathways. J. Biol. Chem. 266:1991;12932-12938.
7. Dusser D.J., Nadel J.A., Sekizawa K., Graf P.D., Borson D.B. Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. J. Pharmacol. Exp. Ther. 244:1988;531-536.
8. 9]BK: influence of enalaprilat. Am. J. Physiol. 270:1996;H1340-H1347.
9. Foote E.F., Halstenson C.E. New therapeutic agents in the management of hypertension: angiotensin II-receptor antagonists and renin inhibitors. Ann. Pharmacother. 27:1993;1495-1503.
10. Fox A.J., Lalloo U.G., Belvisi M.G., Bernareggi M., Chung K.F., Barnes P.J. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat. Med. 2:1996;814-817.
11. Frossard N., Stretton C.D., Barnes P.J. Modulation of bradykinin responses in airway smooth muscle by epithelial enzymes. Agents Actions. 31:1990;204-209.
12. Grunenert D.C., Finkbeiner W.E., Widdicombe J.H. Culture and transformation of human airway epithelial cells. Am. J. Physiol. 268:1995;L347-L360.
13. Holwerda N.J., Fogari R., Angeli P., Porcellati C., Hereng C., Oddou-Stock P., Heath R., Bodin F. Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril. J. Hypertens. 14:1996;1147-1151.
14. Hubert C., Houot A.M., Corvol P., Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J. Biol. Chem. 266:1991;15377-15383.
15. 2 and thromboxane prostanoid receptors. Am. J. Respir. Crit. Care. Med. 150:1994;1012-1018.
16. Ichinose M., Barnes P.J. The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo. Br. J. Pharmacol. 101:1990;77-80.
17. Ishida H., Scicli A.G., Carretero O.A. Role of angiotensin converting enzyme and other peptidases in in vivo metabolism of kinins. Hypertension. 14:1989;322-327.
18. Jetten A.M. Growth and differentiation factors in tracheobronchial epithelium. Am. J. Physiol. 260:1991;L361-L373.
19. Johnson A.R., Ashton J., Schulz W.W., Erdös E.G. Neutral metalloendopeptidase in human lung tissue and cultured cells. Am. Rev. Respir. Dis. 132:1985;564-568.
20. Koyama S., Rennard S.I., Robbins R.A. Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am. J. Physiol. 269:1995;L38-L44.
21. Linz W., Wiemer G., Gohlke P., Unger T., Schölkens B.A. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol. Rev. 47:1995;25-49.
22. Mak J.C.W., Barnes P.J. Autoradiographic visualization of bradykinin receptors in human and guinea pig lung. Eur. J. Pharmacol. 194:1991;37-43.
23. 1. Am. J. Respir. Cell Mol. Biol. 18:1998;823-833.
24. Millar E.A., Angus R.M., Hulks G., Morton J., Connell J.M., Thomson N.C. Activity of the renin-angiotensin system in acute severe asthma and the effect of angiotensin II on lung function. Thorax. 49:1994;492-495.
25. Mitani H., Bandoh T., Kimura M., Totsuka T., Hayashi S. Increased activity of vascular ACE related to artherosclerotic lesions in hyperlipidemic rabbits. Am. J. Physiol. 271:1996;H1065-H1071.
26. Müns G., Vishwanatha J.K., Rubinstein I. Regulation of angiotensin I-converting enzyme in cultured bovine bronchial epithelial cells. J. Cell. Biochem. 53:1993;352-359.
27. Ohkubo K., Lee C.H., Baraniuk J.N., Merida M., Hausfeld J.N., Kaliner M.A. Angiotensin-converting enzyme in the human nasal mucosa. Am. J. Respir. Cell Mol. Biol. 11:1994;173-180.
28. Overlack A. ACE inhibitor-induced cough and bronchospasm. Drug Safety. 15:1996;72-78.
29. Proud D., Subauste M.C., Ward P.E. Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line. Am. J. Respir. Cell Mol. Biol. 11:1994;57-65.
30. Ramchandran R., Kasturi S., Douglas J.G., Sen I. Metalloprotease-mediated cleavage secretion of pulmonary ACE by vascular endothelial and kidney epithelial cells. Am. J. Physiol. 271:1996;H744-H751.
31. Soffer R.L. Angiotensin-converting enzyme and the regulation of vasoactive peptide. Annu. Rev. Biochem. 45:1976;73-94.
32. Specks U., Martin W.J. II, Rohrbach M.S. Bronchoalveolar lavage fluid angiotensin-converting enzyme in interstitial lung diseases. Am. Rev. Respir. Dis. 141:1990;117-123.
33. Studer R., Reinecke H., Müller B., Holtz J., Just H., Drexler H. Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction. J. Clin. Invest. 94:1994;301-310.
34. Sugiyama Y., Yotsumoto H., Okabe T., Takaku F. Measurement of angiotensin-converting enzyme activity in intact human alveolar macrophages and effect of smoking. Respiration. 53:1988;153-157.
35. Takimoto M., Oda K., Sasaki Y., Okada T. Endothelin-A receptor-mediated prostanoid secretion via autocrine and deoxyribonucleic acid synthesis via paracrine signaling in human bronchial epithelial cells. Endocrinology. 137:1996;4542-4550.
36. Tamaoki J., Kobayashi K., Sakai N., Chiyotani A., Kanemura T., Takizawa T. Effect of bradykinin on airway ciliary motility and its modulation by neutral endopeptidase. Am. Rev. Respir. Dis. 140:1989;430-435.