GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding and steroidogenic acute regulatory protein expression during pregnancy

Journal of Molecular Endocrinology

Volumn 22, Issue 1, 1999, Pages 45-54

  Sridaran, R ^c   Philip, G H ^c   Li, H ^a   Culty, M ^a   Liu, Z ^b   Stocco, D M ^b   Papadopoulos, V ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; GONADORELIN AGONIST; LIGAND; MESSENGER RNA; REGULATOR PROTEIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL TRANSPORT; CORPUS LUTEUM; FEMALE; LIGAND BINDING; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; RAT; STEROIDOGENESIS;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORPUS LUTEUM; FEMALE; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; MITOCHONDRIA; PHOSPHOPROTEINS; PHOSPHORYLATION; PREGNANCY; PREGNANCY, ANIMAL; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RNA, MESSENGER;

EID: 0032965206     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0220045     Document Type: Article

References (40)

1. Amri H, Ogwuegbu SO, Boujrad N, Drieu K & Papadopoulos V 1996 In vivo regulation of the peripheral-type benzodiazepine receptor and glucocorticoid synthesis by the Ginkgo biloba extract Egb 761 and isolated ginkgolides. Endocrinology 137 5707-5718.
2. Amsterdam A & Suh BS 1991 An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells. Endocrinology 128 503-510.
3. Anholt KPH, Pedersen PL, DeSouza EB & Synder SH 1986 The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. Journal of Biological Chemistry 261 576-583.
4. Arakane F, King SR, Du Y, Kallen CB, Walsh LP, Watari H, Stocco DM & Strauss JF III 1997 Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. Journal of Biological Chemistry 272 32656-32662.
5. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Analytical Biochemistry 72 248-254.
6. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Kriedberg I, Orly J, Wang XJ, Stocco DM & Capponi AM 1997 Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein, P450 side-chain cleavage and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Journal of Biological Chemistry 272 7899-7907.
7. Chomczynski P & Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Analytical Biochemistry 162 156-159.
8. Clark BJ, Wells J, King SR & Stocco DM 1994 The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA10 mouse Leydig tumor cells. Journal of Biological Chemistry 269 28314-28322.
9. Clark BJ, Soo SC, Caron KM, Ikeda Y, Parker KL & Stocco DM 1995 Hormonal and developmental regulation of the steroidogenic acute regulatory (StAR) protein. Molecular Endocrinology 9 1346-1355.
10. Clayton RN, Harwood JP & Catt KJ 1979 Gonadotropin-releasing hormone analogue binds to luteal cells and inhibits progesterone production. Nature 282 90-92.
11. Clayton RN, Eccleston L, Gossard F, Thalbard J-C & Morel G 1992 Rat granulosa cells express the gonadotropin-releasing hormone gene: evidence from in situ hybridization histochemistry. Journal of Molecular Endocrinology 9 189-195.
12. Epstein LF & Orme-Johnson NR 1991 Regulation of steroid hormone biosynthesis: identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. Journal of Biological Chemistry 266 19739-19745.
13. Fares F, Bar-Ami S, Brandes JM & Gavish M 1988 Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during estrous cycle. Journal of Reproduction and Fertility 83 619-625.
14. Fleischer S & Kervina M 1974 Subcellular fractionation of rat liver. Methods in Enzymology 31 6-41.
15. Garnier M, Dimchev A, Boujrad N, Price MJ, Musto NA & Papadopoulos V 1994 In vitro reconstitution of a functional peripheral-type benzodiazepine receptor. Molecular Pharmacology 45 201-211.
16. Goubau S, Bond CT, Adelman JP, Misra V, Hynes MF, Schultz GA & Murphy BD 1992 Partial characterization of the gonadotropin-releasing hormone (GnRH) gene transcript in the ovary. Endocrinology 130 3098-3100.
17. Juengel JL, Meberg BM, Turzillo AM, Nett TM & Niswender GD 1995 Hormonal regulation of messenger ribonucleic acid encoding steroidogenic acute regulatory protein in ovine corpora lutea. Endocrinology 136 5423-5429.
18. Krueger KE & Papadopoulos V 1990 Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membrane in adrenocortical cells. Journal of Biological Chemistry 265 15015-15022.
19. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 680-685.
20. Leung PCK & Wang J 1989 The role of inositol metabolism in the ovary. Biology of Reproduction 40 703-708.
21. Luu-The V, Lachance Y, Labrie C, Leblanc G, Thomas JL, Strickler RC & Labrie F 1989 Full length cDNA structure and deduced amino acid sequence of human 3β-hydroxy-5-ene stero dehydrogenise. Molecular Endocrinology 3 1310-1312.
22. Minaretzis D, Jakubowski M, Mortola JF & Pavlou SN 1995 Gonadotropin-releasing hormone receptor gene expression in human ovary and granulosa-lutein cells. Journal of Clinical Endocrinology and Metabolism 80 430-434.
23. Munson PJ & Rodbard D 1980 LIGAND: a versatile computerized approach for characterization of ligand binding systems. Analytical Biochemistry 107 220-239.
24. Oikawa M, Dargan C, Ny T & Hsuch AJW 1990 Expression of gonadotropin-releasing hormone and prothymosin-α messenger ribonucleic acid in the ovary. Endocrinology 127 90-92.
25. Papadopoulos V, Mukhin AG, Costa E & Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. Journal of Biological Chemistry 265 3772-3779.
26. Papadopoulos V, Nowzari FB & Kruegar VE 1991 Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. Journal of Biological Chemistry 266 3682-3687.
27. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM & Drieu K 1997α Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62 21-28.
28. Papadopoulos V, Amri H, Boujrad X, Li H, Vidic B & Garnier M 1997b Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. Journal of Biological Chemistry 272 32129-32135.
29. Roby KF, Larsen D, Deb S & Soares MJ 1991 Generation and characterization of antipeptide antibodies to rat cytochrome P-450 side chain cleavage enzyme. Molecular and Cellular Endocrinology 79 13-20.
30. Ronen-Fuhrmann T, Timburg R, King SR, Hales KH, Hales DB, Stocco DM & Orly J 1998 Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary. Endocrinology 139 303-315.
31. Sandhoff TW & McLean MP 1996 Hormonal regulation of steroidogenic acute regulatory (StAR) protein messenger ribonucleic acid expression in the rat ovary. Endocrine 4 259-267.
32. Sridaran R 1987 Ovarian steroid production in rats treated with gonadotropin-rcleasing hormone during early pregnancy. Journal of Steroid Biochemistry 26 1-6.
33. Sridaran R, Basuray R & Gibori G 1981 Source and regulation of testosterone secretion in pregnant and pseudopregnant rats. Endocrinology 108 855-861.
34. Sridaran R, Ghose M & Mahesh VB 1988 Inhibitory effects of gonadotropin-releasing hormone agonist on the luteal synthesis of progesterone, estradiol receptors, and prolactin surges during early pregnancy. Endocrinology 123 1740-1746.
35. Sridaran R, Lee M, Srivastava RK, Haynes L & Azhar S 1995 Relationship between luteal content of cholesterol and serum LH levels in pregnant rats treated with a GnRH agonist in vivo. In Program of the 28th Annual Meeting of the Society for the Study of Reproduction, abstract 214. Davis, CA.
36. Sridaran R, Hisheh S & Dharmarajan AM 1998 Induction of apoptosis by a gonadotropin-releasing hormone agonist during early pregnancy in the rat. Apoptosis 3 51-57.
37. Srivastava RK, Luu-The V, Marrone BL, Harris-Hooker S & Sridaran R 1994 Inhibition of steroidogenesis by luteal cells of early pregnancy in the rat in response to in vitro administration of a gonadotropin-releasing hormone agonist. Journal of Steroid Biochemistry and Molecular Biology 49 73-79.
38. Stocco DM & Clark BJ 1997 The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 62 29-36.
39. Sugawara T, Holt JA, Driscoll D, Strauss JF III, Lin D, Miller WL, Patterson D, Clancy KP, Hart IM, Clark BJ & Stocco DM 1995 Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the gene to 8p11·2 and pseudogene to chromosome 13. Proceedings of the National Academy of Sciences of the USA 92 4778-4782.
40. \Townson DH, Wang XJ, Keyes PL, Kostyo JL & Stocco DM 1996 Expression of the steroid acute regulatory protein (StAR) in the corpus luteum of the rabbit: dependence upon the luteotropic hormone, 17β-estradiol. Biology of Reproduction 55 868-874.