Iron metabolism of the Long-Evans Cinnamon (LEC) rat before the onset of hepatitis

Sapporo Medical Journal

Volumn 65, Issue 6, 1996, Pages 451-462

  Yuasa, Motoyuki ^a   Sugawara, Chieko ^a   Lai, Yu Rong ^a   Sugawara, Naoki ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

Ceruloplasmin; Ceruloplasmin ferroxidase hypothesis; Ferroxidase; Iron; LEC rat

Indexed keywords

EID: 0001559585     PISSN: 0036472X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Mori M, Hattori A, Sawaki M, Tsuzuki N, Sawada N, Oyamada M, Sugawara N, Enomoto K. Animal model-the LEC rat : a model for human hepatitis, liver cancer, and much more. Am J Pathol 1994, 200-204.
2. Li Y, Togashi Y, Sato S, Emoto T, Kang JH, Takeichi N, Kobayashi H, Kojima Y, Une Y, Uchino J. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. J Clin Invest 1991, 87: 1858-1861.
3. Wu J, Forbes JR, Chen HS, Cox DW. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat Genet 1994, 7: 541-545.
4. Sugawara N, Li D, Sugawara C, Miyake H. Decrease in biliary excretion of copper in Long-Evans Cinnamon (LEC) rats causing spontaneous hepatitis due to a gross accumulation of hepatic copper. Res Commun Chem Pathol Pharmacol 1993, 81: 45-52.
5. Sugawara N, Sugawara C, Sato M, Takahashi H, Mori M. Excessive accumulation of hepatic copper in LEC rats aged 80 days without hepatitis and 130 days with hepatitis. Pharmacol Toxicol 1992, 71: 321-324.
6. Sawaki M, Enomoto K, Hattori A, Tsuzuki N, Sugawara N, Mori M. Role of copper accumulation and metallothionein induction in spontaneous liver cancer development in LEC rats. Carcinogenesis 1994, 15: 1833-1837,
7. Murata Y, Yamakawa E, Iizuka T, Kodama H, Abe T, Seki Y, Kodama M. Failure of copper incorporation into ceruloplasmin in the golgi apparatus of LEC rat hepatocytes Biochem Biophys Res Commun 1995, 209: 349-355.
8. Kato J, Kohgo Y, Sugawara N, Katsuki S, Shintani N, Fujikawa K, Miyazaki E, Kobune M, Takeichi N, Niitsu Y. Abnormal hepatic iron accumulation in LEC rats. Jpn J Cancer Res 1993, 84: 219-222.
9. Nakakoshi T, Fujita N, Kang JH, Takeichi N, Miyasaka K. Magnetic resonance imaging of hereditary spontaneous hepatitis in Long-Evans Cinnamon rats. Invest Radiol 1993, 28: 1010-1014.
10. Kato J, Kobune M, Kohgo Y, Sugawara N, Hisai H, Nakamura T, Sakamaki S, Sawada N, Niitsu Y. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats. J Clin Invest 1996, 98: 923-929.
11. Sugawara N, Sugawara C, Katakura M, Takahashi H, Mori M. Copper metabolism in the LEC rat: involvement of induction of metallothionein and disposition of zinc and iron. Experientia 1991, 47: 1060-1063.
12. Price DJ, Joshi JG. Ferritin-binding of beryllium and other divalent metal ions. J Biol Chem 1983, 258: 10873-10880.
13. Singh S, Hider RC, Porter JB. A direct method for quantification of non-transferrin-bound iron. Anal Biochem 1990, 186: 320-323.
14. Johnson DA, Osaki S, Frieden E. A micromethod for the determination of ferroxidase (ceruloplasmin) in human serums Clin Chem 1967, 13: 142-150.
15. Ravin HA. An improved colorimetric enzymatic assay of ceruloplasmin. J Lab Clin Med 1961, 58: 161-168.
16. Mori M, Yoshida MC, Takeichi N, Taniguchi N (Eds.). The LEC rat-a new model for hepatitis and liver cancer. Tokyo, Springer-Verlag, 1991.
17. Harris ED. Copper transport: an overview Proc Soc Exp Biol Med 1991, 196: 130-140.
18. Raju KS, Alessandri G, Ziche M, Gullino PM. Ceruloplasmin, copper ions, and angiogenesis. J Natl Cancer Inst 1982, 69: 1183-1188.
19. Goldstern IM, Kaplan HB, Edelson HS, Weissmann G Ceruloplasmin - a scavenger of superoxide anion radicals. J Biol Chem 1979, 254: 4040-4045.
20. Osaki S, Johnson DA, Frieden E. The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 1966, 241: 2746-2751.
21. Osaki S, Johnson DA, Frieden E The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I . J Biol Chem 1971, 246: 3018-3023.
22. Harris ED. Iron-copper interactions: some new revelations- Nutr Rev 1994, 52: 311-315.
23. Owen CA, Jr. Effects of iron on copper metabolism and copper on iron metabolism in rats. Am J Physiol 1973, 224: 514-518.
24. Roeser HP, Lee GR, Nacht S, Cartwright GE. The role of ceruloplasmin in iron metabolism. J Clin Invest 1970, 49: 2408-2417.
25. Topham RW, Walker MC, Calisch MP, Williams RW. Evidence for the participation of intestinal xanthine oxidase in the mucosal processing of iron. Biochemistry 1982, 21: 4529-4535.
26. Cohen KL, Keen CL, Lonnerdal B, Hurley LS. Effects of varying dietary iron on the expression of copper deficiency in the growing rat: anemia, ferroxidase I and II, tissue trace elements, ascorbic acid, and xanthine dehydrogenase. J Nutr 1985, 115: 633-649.
27. Williams DM, Lee GR, Cartwright GE. Ferroxidase activity of rat ceruloplasmin. Am J Physiol 1974, 227: 1094-1097.
28. Conrad ME, Weintraub LR, Crosby WH, Merrill B, Foy A. The role of the intestine in iron kinetics. J Clin Invest 1964, 43: 963-974.
29. Lu JP, Hayashi K, Awai M Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats. Acta Pathol Jpn 1989, 39: 759-764.
30. Urushizaki I. Trends in research of iron binding proteins. Acta Haematol Jpn 1986, 49: 1620-1626.
31. LeSage GD, Kost LJ, Barbara SS, LaRusso NF. Biliary excretion of iron from hepatocyte lysosomes in the rat - a major excretory pathway in experimental iron overload. J Clin Invest 1986, 77: 90-97.
32. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 2nd ed. Oxford, Clarendon Press, 1989.
33. Askwith C, Eide D, Ho AV, Bernard PS, Li L, Davis-Kaplan S, Sipe DM, Kaplan J. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 1994, 76: 403-410.
34. Harris ZL, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RTA, Gitlin JD. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci USA 1995, 92: 2539-2543.
35. Okamoto N, Wada S, Oga T, Kawabata Y, Baba Y, Habu D, Takeda Z, Wada Y. Hereditary ceruloplasmin deficiency with hemosiderosis. Hum Genet 1996, 97: 755-758.