-
1
-
-
0015840363
-
Angiotensin ii blockade in man by sar 1-ala 8-angiotensin ii for understanding and treatment of high blood pressure
-
Brunner HR Angiotensin II blockade in man by Sar 1-Ala 8-angiotensin II for understanding and treatment of high blood pressure. Lancet 1973; ii: 1045 - 1048.
-
(1973)
Lancet
, vol.2
-
-
Brunner, H.R.1
-
2
-
-
0015973263
-
-
Ogihara T Angiotensin blockage. Lancet 1974; i: 219.
-
(1974)
Lancet
, pp. 219
-
-
Ogihara, T.1
-
5
-
-
0025832708
-
-
Timmermans PBMWM The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists. Am J Hypertens 1991; 4; 275S- 281S.
-
(1991)
Am J Hypertens
, vol.4
, pp. 275S-281S
-
-
Timmermans, P.1
-
6
-
-
0344069405
-
Pharmacological profile of a highly potent and long-acting angiotensin ii receptor antagonist, 2-ethoxy-l-[[2'-(Lh-tetrazol-5-yl)biphenyl-4-yl) methyl]-lh-benzimidazole-7-carboxylic acid (cv- 11974), and its prodrug, (±)-l-(cyclohexyloxycarbony- loxy)ethyl 2-ethoxy-l-[[2'-(lh-terazol-5-yl)biphenyl-4- yl) methyl] -1 h-benzimidazole-7-carboxylate (tcv- 116).;
-
Shibouta T Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-l-[[2'-(lH-tetrazol-5-yl)biphenyl-4-yl] methyl]-lH-benzimidazole-7-carboxylic acid (CV- 11974), and its prodrug, (±)-l-(cyclohexyloxycarbony- loxy)ethyl 2-ethoxy-l-[[2'-(lH-terazol-5-yl)biphenyl-4- yl] methyl] -1 H-benzimidazole-7-carboxylate (TCV- 116).; Pharmacol Exp Ther 1993; 266; 144-150.
-
(1993)
Pharmacol Exp Ther
, vol.266
, pp. 144-150
-
-
Shibouta, T.1
-
7
-
-
0027281668
-
Inhibition of rabbit aortic angiotensin ii (All) receptor by cv-11974, a new nonpeptide all antagonists
-
Noda M Inhibition of rabbit aortic angiotensin II (All) receptor by CV-11974, a new nonpeptide All antagonists. Biochem Pharmacol 1993; 46; 311-318.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 311-318
-
-
Noda, M.1
-
8
-
-
0030722237
-
Absorption, metabolism and excretion of mc-candesartan and hc-candesartan cilexetil in healthy volunteers
-
HC-candesartan cilexetil in healthy volunteers. J Hum Hypertens 1997; 11 (Suppl 2); S27-S28.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S27-S28
-
-
Van Lier, J.J.1
-
9
-
-
0030679672
-
Candesartan cilexetil review of its preclinical pharmacology
-
Nishikawa K Candesartan cilexetil review of its preclinical pharmacology. J Hum Hypertens 1997; 11 (Suppl 2); S9-S17.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S9-S17
-
-
Nishikawa, K.1
-
10
-
-
0028609322
-
Tcv-116: A new angiotensin ii type-1 receptor antagonist
-
Morimoto S, Ogihara T. TCV-116: a new angiotensin II type-1 receptor antagonist. Cardiovasc Drug Rev1994; 12: 153-164.
-
(1994)
Cardiovasc Drug Rev
, vol.12
, pp. 153-164
-
-
Morimoto, S.1
Ogihara, T.2
-
11
-
-
0030800377
-
Protective effects of candesartan cilexetil (Tcv-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats
-
Inada Y Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens 1997; 19: 1079-1099.
-
(1997)
Clin Exp Hypertens
, vol.19
, pp. 1079-1099
-
-
Inada, Y.1
-
12
-
-
0028956159
-
Role of angiotensin ii in cerebrovascular and renal damages in deoxycorticosterone acetate-salt hypertensive rats
-
Wada T et al. Role of angiotensin II in cerebrovascular and renal damages in deoxycorticosterone acetate-salt hypertensive rats. J Hypertens 1995; 13: 113-122.
-
(1995)
J Hypertens
, vol.13
, pp. 113-122
-
-
Wada, T.1
-
13
-
-
0028338639
-
Effects of the angiotensin ii receptor antagonist, tcv-116, on blood pressure and the renin- angiotensin system in healthy subjects
-
Ogihara T Effects of the angiotensin II receptor antagonist, TCV-116, on blood pressure and the renin- angiotensin system in healthy subjects. Clin Ther1994; 16: 74-86.
-
(1994)
Clin Ther
, vol.16
, pp. 74-86
-
-
Ogihara, T.1
-
14
-
-
0027272498
-
Pilot study of a new angiotensin ii receptor antagonist, tcv-116: Effects of a single oral dose on blood pressure in patients with essential hypertension
-
Ogihara T Pilot study of a new angiotensin II receptor antagonist, TCV-116: effects of a single oral dose on blood pressure in patients with essential hypertension. Clin Ther 1993; 15: 684-691.
-
(1993)
Clin Ther
, vol.15
, pp. 684-691
-
-
Ogihara, T.1
-
15
-
-
0028004615
-
Open clinical studies on a new angiotensin ii receptor antagonist, tcv-116
-
Ogihara T Open clinical studies on a new angiotensin II receptor antagonist, TCV-116. J Hypertens1994; 12: S35-S38.
-
(1994)
J Hypertens
, vol.12
, pp. S35-S38
-
-
Ogihara, T.1
-
16
-
-
0028143725
-
Role of the renin-angiotensin system in hypertension in the elderly
-
Nagano M et al. Role of the renin-angiotensin system in hypertension in the elderly. Blood Press Suppl1994; 5: 130-133.
-
(1994)
Blood Press Suppl
, vol.5
, pp. 130-133
-
-
Nagano, M.1
-
17
-
-
0029145962
-
Persistent inhibition of the pressor response and aldosterone responses to angiotensin ii by tcv-116 in normotensive subjects
-
Ogihara T Persistent inhibition of the pressor response and aldosterone responses to angiotensin II by TCV-116 in normotensive subjects. J Cardiovasc Pharmacol 1995; 26: 490-494.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, pp. 490-494
-
-
Ogihara, T.1
-
18
-
-
0028899737
-
Characterization of the angiotensin ii receptor antagonist tcv-116 in healthy volunteers
-
Delacretaz E Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers. Hypertension 1995; 25: 14-21.
-
(1995)
Hypertension
, vol.25
, pp. 14-21
-
-
Delacretaz, E.1
-
19
-
-
0030720101
-
Twenty-four hour blood pressure profile of different doses of candesartan cilexetil in patients with mild to moderate hypertension
-
Heuer HJ Twenty-four hour blood pressure profile of different doses of candesartan cilexetil in patients with mild to moderate hypertension. J Hum Hypertens 1997; 11 (Suppl 2): S55-S56.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S55-S56
-
-
Heuer, H.J.1
-
20
-
-
0344069401
-
Efficacy and safety of tcv-116 (Candesartan cilexetil), an angiotensin ii receptor antagonist, on essential hypertension in long-term treatment
-
Fukiyama K Efficacy and safety of TCV-116 (candesartan cilexetil), an angiotensin II receptor antagonist, on essential hypertension in long-term treatment. Rinsho-Iyaku 1996; 12: 3229-3264.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 3229-3264
-
-
Fukiyama, K.1
-
21
-
-
0344069400
-
Hypotensive effect and safety of tcv- 116 (Candesartan cilexetil), a new angiotensin ii receptor antagonist, in patients with essential hypertension. Clinical late phase ii study
-
Arakawa K Hypotensive effect and safety of TCV- 116 (candesartan cilexetil), a new angiotensin II receptor antagonist, in patients with essential hypertension. Clinical late phase II study. Runsho-Iyaku 1996; 12: 2231-2266.
-
(1996)
Runsho-Iyaku
, vol.12
, pp. 2231-2266
-
-
Arakawa, K.1
-
22
-
-
0344500503
-
Hypotensive effect and safety of tcv-116 (Candesartan cilexetil), a new angiotensin ii receptor antagonist, combination therapy with thiazides on essential hypertension. Clinical late phase ii study
-
Arakawa M Hypotensive effect and safety of TCV-116 (candesartan cilexetil), a new angiotensin II receptor antagonist, combination therapy with thiazides on essential hypertension. Clinical late phase II study. Rinsho-Iyaku 1996; 12: 2267-2296.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2267-2296
-
-
Arakawa, M.1
-
23
-
-
0344500502
-
Efficacy and safety of candesartan cilexetil (Tcv-116) on essential hypertension in combination therapy with calcium antagonists
-
Saruta T Efficacy and safety of candesartan cilexetil (TCV-116) on essential hypertension in combination therapy with calcium antagonists. Rinsho-Iyaku1996; 12: 2297-2322.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2297-2322
-
-
Saruta, T.1
-
24
-
-
0009313637
-
The effect of tcv-116, an angiotensin ii receptor antagonist, on lipid metabolism in patients with essential hypertension
-
Kajiyama G The effect of TCV-116, an angiotensin II receptor antagonist, on lipid metabolism in patients with essential hypertension. Rinsho-Iyaku1996; 12: 3299-3317.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 3299-3317
-
-
Kajiyama, G.1
-
25
-
-
0345362908
-
Effects of tcv-116 (Candesartan cilexetil) on left ventricular hypertrophy and glucose tolerance in patients with essential hypertension
-
Fujiwara H Effects of TCV-116 (candesartan cilexetil) on left ventricular hypertrophy and glucose tolerance in patients with essential hypertension. Rin- sho-Iyaku 1996; 12: 3281-3297.
-
(1996)
Rin- Sho-Iyaku
, vol.12
, pp. 3281-3297
-
-
Fujiwara, H.1
-
26
-
-
0344931564
-
Efficacy and safety of tcv-116 (Candesartan cilexetil), a new angiotensin ii receptor antagonist, in patients with severe hypertension
-
Iimura O Efficacy and safety of TCV-116 (candesartan cilexetil), a new angiotensin II receptor antagonist, in patients with severe hypertension. Rin- sho-Iyaku 1996; 12: 2323-2364.
-
(1996)
Rin- Sho-Iyaku
, vol.12
, pp. 2323-2364
-
-
Iimura, O.1
-
27
-
-
0009383616
-
Efficacy and safety of candesartan cilexetil (Tcv-116) in hypertensive patients with renal failure
-
Fujishima M Efficacy and safety of candesartan cilexetil (TCV-116) in hypertensive patients with renal failure. Rinsho-Iyaku 1996; 12: 2343-2371.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2343-2371
-
-
Fujishima, M.1
-
28
-
-
0344069398
-
Efficacy and safety of tcv-116 (Candesartan cilexetil), an angiotensin ii receptor antagonist, in the elderly with hypertension
-
Ogihara T Efficacy and safety of TCV-116 (candesartan cilexetil), an angiotensin II receptor antagonist, in the elderly with hypertension. Rinsho- Iyaku 1996; 12: 3211-3228.
-
(1996)
Rinsho- Iyaku
, vol.12
, pp. 3211-3228
-
-
Ogihara, T.1
-
29
-
-
0000870375
-
Evaluation of clinical usefulness of tcv-116 (Candesartan cilexetil) in patients with essential hypertension. A double-blind, parallel group-com- parison study using enalapril maleate as control dmg
-
Arakawa K Evaluation of clinical usefulness of TCV-116 (candesartan cilexetil) in patients with essential hypertension. A double-blind, parallel group-com- parison study using enalapril maleate as control dmg. Rinsyo-Iyaku 1998; 14: 871-918.
-
(1998)
Rinsyo-Iyaku
, vol.14
, pp. 871-918
-
-
Arakawa, K.1
-
30
-
-
0344931561
-
Effect of candesartan cilexetil, a novel angiotensin ii receptor antagonist, on the diurnal blood pressure variation in patients with essential hypertension
-
Arakawa K Effect of candesartan cilexetil, a novel angiotensin II receptor antagonist, on the diurnal blood pressure variation in patients with essential hypertension. Rinsho-Iyaku 1996; 12: 2195-2211.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2195-2211
-
-
Arakawa, K.1
-
31
-
-
0345362907
-
Efficacy and safety of candesartan cilexetil, a novel angiotensin ii receptor antagonist, in patients with essential hypertension
-
Arakawa K Efficacy and safety of candesartan cilexetil, a novel angiotensin II receptor antagonist, in patients with essential hypertension. Rinsho-Iyaku1996; 12: 2213-2230.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2213-2230
-
-
Arakawa, K.1
-
32
-
-
0344500501
-
Antihypertensive effect and safety of tcv- 116 (Candesartan cilexetil) in patients with essential hypertension. Study with the initial daily dose of 4 mg
-
Abe K Antihypertensive effect and safety of TCV- 116 (candesartan cilexetil) in patients with essential hypertension. Study with the initial daily dose of 4 mg. Rinsho-Iyaku 1996; 12: 2373-2392.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2373-2392
-
-
Abe, K.1
-
33
-
-
0344500500
-
Antihypertensive effect and safety of tcv- 116 (Candesartan cilexetil), an angiotensin ii receptor antagonist, in patients with essential hypertension. Study with the initial daily dose of 8 mg
-
Abe K Antihypertensive effect and safety of TCV- 116 (candesartan cilexetil), an angiotensin II receptor antagonist, in patients with essential hypertension. Study with the initial daily dose of 8 mg. Rinsho-Iyaku1996; 12: 2393-2411.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 2393-2411
-
-
Abe, K.1
-
34
-
-
0030661710
-
Candesartan cilexetil, a new generation angiotensin ii antagonist, provides dose dependent antihypertensiveeffect
-
Elmfeldt D Candesartan cilexetil, a new generation angiotensin II antagonist, provides dose dependent antihypertensive effect. J Hum Hypertens 1997; 11 (Suppl 2): S49-S53.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S49-S53
-
-
Elmfeldt, D.1
-
35
-
-
0022551420
-
-
Tuck ML Low dose captopril in mild to moderate geriatric hypertension. J Am Ger Soc 1986; 34: 693- 696.
-
(1986)
J am Ger Soc
, vol.34
-
-
Tuck, M.L.1
-
36
-
-
0030707643
-
The efficacy and tolerability of candesartan cilexetil in an elderly hypertensive population
-
Mclnnes GT The efficacy and tolerability of candesartan cilexetil in an elderly hypertensive population. J Hum Hypertens 1997; 11 (Suppl 2): S75-S80.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S75-S80
-
-
McLnnes, G.T.1
-
37
-
-
0030699197
-
Candesartan cilexetil and enalapril are of equivalent efficacy in patients with mild to moderate hypertension
-
Zanchetti A Candesartan cilexetil and enalapril are of equivalent efficacy in patients with mild to moderate hypertension. J Hum Hypertens 1997; 11 (Suppl 2); S57-S59.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S57-S59
-
-
Zanchetti, A.1
-
38
-
-
0030712995
-
Antihypertensive effects of candesartan cilexetil, enalapril and placebo
-
Fanke H. Antihypertensive effects of candesartan cilexetil, enalapril and placebo. J Hum Hypertens1997; 11 (Suppl 2): S61-S62.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S61-S62
-
-
Fanke, H.1
-
39
-
-
0030661711
-
A comparison of the antihypertensiveeffects of candesartan cilexetil and losarían in patients with mild to moderate hypertension
-
Andersson OK, Neldam S. A comparison of the antihypertensive effects of candesartan cilexetil and losarían in patients with mild to moderate hypertension. J Hum Hypertens 1997; 11 (Suppl 2): S63-S64.
-
(1997)
J Hum Hypertens
, vol.11
, pp. S63-S64
-
-
Andersson, O.K.1
Neldam, S.2
-
40
-
-
0002735691
-
-
Part 2, abstract
-
Farsang C Antihypertensive effects and tolerability of candesartan cilexetil, amlodipine and their combination. Am J Hypertens 1997; 10(4), Part 2: 80A (abstract).
-
(1997)
Am J Hypertens
, vol.10
, Issue.4
, pp. 80A
-
-
Farsang, C.1
-
41
-
-
0009409191
-
Effects of an angiotensin ii receptor antagonist, tcv-116 (Candesartan cilexetil) on renal function in essential hypertension
-
Ise T Effects of an angiotensin II receptor antagonist, TCV-116 (candesartan cilexetil) on renal function in essential hypertension. Rinsho-Iyaku 1996; 12: 3265-3280.
-
(1996)
Rinsho-Iyaku
, vol.12
, pp. 3265-3280
-
-
Ise, T.1
-
42
-
-
0344500493
-
Effects of candesartan cilexetil (Tcv-116), an angiotensin ii receptor antagonist, on cardiac hypertrophy and cardiac function
-
Mitsunami K Effects of candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, on cardiac hypertrophy and cardiac function. J New Rem Clin 1996; 45: 1655-1661.
-
(1996)
J New Rem Clin
, vol.45
, pp. 1655-1661
-
-
Mitsunami, K.1
|