Determination of the rate-limiting step in the hepatic elimination of YM796 by isolated rat hepatocytes

Pharmaceutical Research

Volumn 16, Issue 1, 1999, Pages 110-116

  Iwatsubo, Takafumi ^a   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Clearance; Efflux; Hepatocytes; Influx; Membrane permeability; Metabolism; Rate limiting step

Indexed keywords

2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE;

ANIMAL CELL; ARTICLE; DRUG CLEARANCE; DRUG ELIMINATION; DRUG PENETRATION; DRUG UPTAKE; LIVER CELL; LIVER CLEARANCE; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL MEMBRANE PERMEABILITY; CULTURE MEDIA; LIVER; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, WISTAR; SPIRO COMPOUNDS;

EID: 0032963730     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018883115189     Document Type: Article

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