Synthesis and evaluation of 2-amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine mono- and diesters as potential prodrugs of ganciclovir

Journal of Medicinal Chemistry

Volumn 42, Issue 2, 1999, Pages 324-328

  Kim, Dae Kee ^a   Chang, Kieyoung ^a   Im, Guang Jin ^a   Kim, Hun Taek ^a   Lee, Namkyu ^a   Kim, Key H ^a  

^a SK Chemicals   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 FLUORO 9 (1 ISOBUTYRYLOXY 3 HYDROXY 2 PROPOXYMETHYL)PURINE; 2 AMINO 9 (1,3 DIISOPROPOXY 2 PROPOXYMETHYL)PURINE; ANTIVIRUS AGENT; GANCICLOVIR; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME SUBSTRATE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE; CELL SURVIVAL; CYTOMEGALOVIRUS; DRUG EVALUATION; ESTERS; GANCICLOVIR; HUMANS; MALE; PLAQUE ASSAY; PRODRUGS; PURINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032960410     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980321+     Document Type: Article

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