Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA

RNA

Volumn 5, Issue 4, 1999, Pages 562-573

  Brogna, Saverio ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drosophila Adh; mRNA degradation; Nonsense mutations; pre mRNA 3' end formation; Translation

Indexed keywords

ALCOHOL DEHYDROGENASE; MESSENGER RNA; POLYADENYLIC ACID;

ARTICLE; CODON; DROSOPHILA MELANOGASTER; GENE MUTATION; NONHUMAN; NONSENSE MUTATION; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA PROCESSING; RNA TRANSLATION;

ALCOHOL DEHYDROGENASE; ANIMALS; BASE SEQUENCE; CODON, TERMINATOR; DROSOPHILA MELANOGASTER; MOLECULAR SEQUENCE DATA; MUTATION; POLY A; RIBONUCLEASE H, CALF THYMUS; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, MESSENGER;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0032956684     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838299981359     Document Type: Article

References (45)

1. Amrani N, Minet M, LeGouar M, Lacroute F, Wyers F. 1997. Yeast Pab1 interacts with Rna15 and participates in the control of the poly(A) tail length in vitro. Mol Cell Biol 17:3694-3701.
2. Aoufouchi S, Yelamos J, Milstein C. 1996. Nonsense mutations inhibit RNA splicing in a cell-free system: Recognition of mutant codon is independent of protein synthesis. Cell 85:415-422.
3. Applequist SE, Selg M, Raman C, Jack HM. 1997. Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res 25:814-821.
4. Ashburner M. 1989. Drosophila: A laboratory handbook. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
5. Beelman CA, Parker R. 1995. Degradation of messenger-RNA in eukaryotes. Cell 81:179-183.
6. Belgrader P, Cheng J, Zhou XB, Stephenson LS, Maquat LE. 1994. Mammalian nonsense codons can be cis effectors of nuclear messenger-RNA half-life. Mol Cell Biol 74:8219-8228.
7. Belgrader P, Maquat LE. 1994. Nonsense but not missense mutations can decrease the abundance of nuclear messenger-RNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol 14:6326-6336.
8. Benyajati C, Place AR, Wang N, Pentz E, Sofer W. 1982. Deletions at intervening sequence splice sites in the alcohol dehydrogenase gene of Drosophila. Nucleic Acids Res 10:7261-7272.
9. Benyajati C, Spoerel N, Haymerle H, Ashburner M. 1983. The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages. Cell 33:125-133.
10. Brogna S, Ashburner M. 1997. The Adh-related gene of Drosophila melanogaster is expressed as a functional dicistronic messenger RNA: Multigenic transcription in higher organisms. EMBO J 16:2023-2031.
11. Carter MS, Li SL, Wilkinson MF. 1996. A splicing-dependent regulatory mechanism that detects translation signals. EMBO J 15:5965-5975.
12. Chan HYE, Zhang Y, Hoheisel J, O'Kane CJ. 1998. Identification and characterization of the gene for Drosophila L3 ribosomal protein. Gene 212:119-125.
13. Chia W, Savakis C, Karp R, Ashburner M. 1987. Adhn4 of Drosophila melanogaster is a nonsense mutation. Nucleic Acids Res 15:3931.
14. Colgan DF, Manley JL. 1997. Mechanism and regulation of mRNA polyadenylation. Genes & Dev 11:2755-2766.
15. Couttet P, Fromont Racine M, Steel D, Pictet R, Grange T. 1997. Messenger RNA deadenylylation precedes decapping in mammalian cells. Proc Natl Acad Sci USA 94:5628-5633.
16. Cui Y, Hagan KW, Zhang SA, Peltz SW. 1995. Identification and characterization of genes that are required for the accelerated degradation of messenger-RNAs containing a premature translational termination codon. Genes & Dev 9:423-436.
17. Decker CJ, Parker R. 1994. Mechanisms of messenger-RNA degradation in eukaryotes. Trends Biochem Sci 19:336-340.
18. Dietz HC, Kendzior RJ. 1994. Maintenance of an open reading frame as an additional level of scrutiny during splice-site selection. Nat Genet 8:183-188.
19. Fossett NG, Arbourreily P, Kilroy G, McDaniel M, Mahmoud J, Tucker AB, Chang SH, Lee WR. 1990. Analysis of enu-induced mutations at the Adh locus in Drosophila melanogaster. Mutation Res 231:73-85.
20. Freeth AL, Gibson JB, Wilks AV. 1990. Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila melanogaster. Genome 33:873-877.
21. Leeds P, Peltz SW, Jacobson A, Culbertson MR. 1991. The product of the yeast Upf1 gene is required for rapid turnover of messenger-RNAs containing a premature translational termination codon. Genes & Dev 5:2303-2314.
22. Li SL, Leonard D, Wilkinson MF. 1997a. T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: A nuclear-associated translation-like mechanism. J Exp Med 185:985-992.
23. Li SL, Leonard D, Wilkinson MF. 1997b. T-cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: A nuclear-associated translation-like mechanism (vol 185, pg 985-992). J Exp Med 185:1883.
24. Lozano F, Maertzdorf B, Pannell R, Milstein C. 1994. Low cytoplasmic messenger-RNA levels of immunoglobulin-kappa light-chain genes containing nonsense codons correlate with inefficient splicing. EMBO J 13:4617-4622.
25. Maquat LE. 1995. When cells stop making sense: Effects of nonsense codons on RNA-metabolism in vertebrate cells. RNA 1:453-465.
26. Martin PF, Place AR, Pentz E, Sofer W. 1985. UGA nonsense mutation in the alcohol dehydrogenase gene of Drosophila melanogaster. J Mol Biol 184:221-229.
27. McCracken S, Fong N, Yankulov K, Ballantyne S, Pan GH, Greenblatt J, Patterson SD, Wickens M, Bentley DL. 1997. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385:357-361.
28. Minvielle-Sebastia L, Preker PJ, Wiederkehr T, Strahm Y, Keller W. 1997. The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3′-end formation. Proc Natl Acad Sci USA 94:7897-7902.
29. Muhlrad D, Parker R. 1994. Premature translational termination triggers mRNA decapping. Nature 340:578-581.
30. Nagy E, Maquat LE. 1998. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance. Trends Biochem Sci 23:198-199.
31. Peltz SW, He F, Welch E, Jacobson A. 1994. Nonsense-mediated messenger-RNA decay in yeast. Prog Nucleic Acid Res Mol Biol 47:271-298.
32. Perlick HA, Medghalchi SM, Spencer FA, Kendzior RJ, Dietz HC. 1996. Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc Natl Acad Sci USA 93:10928-10932.
33. Proudfoot N. 1996. Ending the message is not so simple. Cell 87:779-781.
34. Ruizechevarria MJ, Czaplinski K, Peltz SW. 1996. Making sense of nonsense in yeast. Trends Biochem Sci 21:433-438.
35. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: A laboratory manual. (2nd ed.). Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
36. Savakis C, Ashburner M. 1985. A simple gene with a complex pattern of transcription: The alcohol dehydrogenase gene of Drosophila melanogaster. Cold Spring Harb Symp Quant Biol 50:505-514.
37. Shaffer CD, Wuller JM, Elgin SCR. 1994. Preparation of Drosophila nuclei. In: Goldstein LSB Fyrberg EA eds. Drosophila melanogaster: Practical uses in cell and molecular biology. San Diego, California: Academic Press, Inc. pp 185-189.
38. Thermann R, Neu Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE. 1998. Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J 17:3484-3494.
39. Urlaub G, Mitchell PJ, Ciudad CJ, Chasin LA. 1989. Nonsense mutations in the dihydrofolate-reductase gene affect RNA processing. Mol Cell Biol 9:2868-2880.
40. Wahle E. 1995. Poly(A) tail length control is caused by termination of processive synthesis. J Biol Chem 270:2800-2808.
41. Wickens M. 1992. Forward, backward, how much and when: Mechanisms of poly(A) addition and removal and their role in early development. Semin Dev Biol 3:399-412.
42. Yang H, McLeese J, Weisbart M, Dionne JL, Lemaire I, Aubin RA. 1993. Simplified high throughput protocol for Northern hybridization. Nucleic Acids Res 21:3337-3338.
43. Zangar RC, Hernandez M, Kocarek TA, Novak RF. 1995. Determination of the poly(a) tail lengths of a single messenger-RNA species in total hepatic RNA. Biotechniques 18:465-469.
44. Zhang J, Sun XL, Qian YM, LaDuca JP, Maquat LE. 1998a. At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear splicing and cytoplasmic translation. Mol Cel Biol 18:5272-5283.
45. Zhang J, Sun XL, Qian YM, Maquat LE. 1998b. Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4:801-815.