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Volumn 67, Issue 5, 1999, Pages 2503-2514

Structural requirements of the major protective antibody to Haemophilus influenzae type B

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIGEN EXPRESSION; ARTICLE; BACTERICIDAL ACTIVITY; HAEMOPHILUS INFLUENZAE TYPE B; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SOMATIC MUTATION;

EID: 0032953203     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.5.2503-2514.1999     Document Type: Article
Times cited : (15)

References (51)
  • 1
    • 0026518919 scopus 로고
    • Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of Vκ and Vλ segments and VJ combinations
    • Adderson, E. E., P. G. Shackelford, R. A. Insel, A. Quinn, P. M. Wilson, and W. L. Carroll. 1992. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of Vκ and Vλ segments and VJ combinations. J. Clin. Investig. 89:729-738.
    • (1992) J. Clin. Investig. , vol.89 , pp. 729-738
    • Adderson, E.E.1    Shackelford, P.G.2    Insel, R.A.3    Quinn, A.4    Wilson, P.M.5    Carroll, W.L.6
  • 2
    • 0025787513 scopus 로고
    • Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide
    • Adderson, E. E., P. G. Shackelford, A. Quinn, and W. L. Carroll. 1991. Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide. J. Immunol. 147: 1667-1674.
    • (1991) J. Immunol. , vol.147 , pp. 1667-1674
    • Adderson, E.E.1    Shackelford, P.G.2    Quinn, A.3    Carroll, W.L.4
  • 3
    • 0027503450 scopus 로고
    • Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenzae type b capsular polysaccharide
    • Adderson, E. E., P. G. Shackelford, A. Quinn, P. M. Wilson, and W. L. Carroll. 1993. Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenzae type b capsular polysaccharide. Pediatr. Res. 33:307-311.
    • (1993) Pediatr. Res. , vol.33 , pp. 307-311
    • Adderson, E.E.1    Shackelford, P.G.2    Quinn, A.3    Wilson, P.M.4    Carroll, W.L.5
  • 4
    • 0027216150 scopus 로고
    • Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens
    • Adderson, E. E., P. G. Shackelford, A. Quinn, P. M. Wilson, M. W. Cunningham, R. A. Insel, and W. L. Carroll. 1993. Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. J. Clin. Investig. 91:2734-2743.
    • (1993) J. Clin. Investig. , vol.91 , pp. 2734-2743
    • Adderson, E.E.1    Shackelford, P.G.2    Quinn, A.3    Wilson, P.M.4    Cunningham, M.W.5    Insel, R.A.6    Carroll, W.L.7
  • 5
    • 0029885801 scopus 로고    scopus 로고
    • New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism
    • Atkinson, M. J., M. J. Cowan, and A. J. Feeney. 1996. New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism. Immunogenetics 44:115-120.
    • (1996) Immunogenetics , vol.44 , pp. 115-120
    • Atkinson, M.J.1    Cowan, M.J.2    Feeney, A.J.3
  • 6
    • 0030293454 scopus 로고    scopus 로고
    • The progeny of a single virgin B cell predominates the human recall B cell response to the capsular polysaccharide of Haemophilus influenzae type b
    • Barington, T., L. Hougs, L. Juul, H. O. Madsen, L. P. Ryder, C. Heilmann, and A. Svejgaard. 1996. The progeny of a single virgin B cell predominates the human recall B cell response to the capsular polysaccharide of Haemophilus influenzae type b. J. Immunol. 157:4016-4027.
    • (1996) J. Immunol. , vol.157 , pp. 4016-4027
    • Barington, T.1    Hougs, L.2    Juul, L.3    Madsen, H.O.4    Ryder, L.P.5    Heilmann, C.6    Svejgaard, A.7
  • 7
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23-41.
    • (1987) Immunol. Rev. , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 8
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral b cells using single-cell polymerase chain reaction
    • Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral b cells using single-cell polymerase chain reaction. J. Immunol. 155:190-202.
    • (1995) J. Immunol. , vol.155 , pp. 190-202
    • Brezinschek, H.P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 10
    • 0024159308 scopus 로고
    • Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae. Germ-line but not mutated T15 antibodies are dominantly selected
    • Claflin, J. L., and J. Berry. 1988. Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae. Germ-line but not mutated T15 antibodies are dominantly selected. J. Immunol. 141:4012-4019.
    • (1988) J. Immunol. , vol.141 , pp. 4012-4019
    • Claflin, J.L.1    Berry, J.2
  • 11
    • 0016808134 scopus 로고
    • Capsular polymer of Haemophilus influenzae, type b. I. Structural characterization of the capsular polymer of strain Eagan
    • Crisel, R. M., R. S. Baker, and D. E. Dorman. 1975. Capsular polymer of Haemophilus influenzae, type b. I. Structural characterization of the capsular polymer of strain Eagan. J. Biol. Chem. 250:4926-4930.
    • (1975) J. Biol. Chem. , vol.250 , pp. 4926-4930
    • Crisel, R.M.1    Baker, R.S.2    Dorman, D.E.3
  • 12
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 5:2459-2468.
    • (1986) EMBO J. , vol.5 , pp. 2459-2468
    • Cumano, A.1    Rajewsky, K.2
  • 15
    • 0029664445 scopus 로고    scopus 로고
    • A defective Vκ A2 allele in Navajos which may play a role in increased susceptibility to Haemophilus influenzae type b disease
    • Feeney, A. J., M. J. Atkinson, M. J. Cowan, G. Escuro, and G. Lugo. 1996. A defective Vκ A2 allele in Navajos which may play a role in increased susceptibility to Haemophilus influenzae type b disease. J. Clin. Investig. 97: 2277-2282.
    • (1996) J. Clin. Investig. , vol.97 , pp. 2277-2282
    • Feeney, A.J.1    Atkinson, M.J.2    Cowan, M.J.3    Escuro, G.4    Lugo, G.5
  • 16
    • 0028173444 scopus 로고
    • H junctions in monoclonal anti-bodies derived in response to dextran B512 could be the result of developmental selection
    • H junctions in monoclonal anti-bodies derived in response to dextran B512 could be the result of developmental selection. Scand. J. Immunol. 40:581-590.
    • (1994) Scand. J. Immunol. , vol.40 , pp. 581-590
    • Fernandez, C.1
  • 18
    • 0027522632 scopus 로고
    • Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation
    • Granoff, D. M., P. G. Shackelford, S. J. Holmes, The Collaborative Vaccine Study Group, and A. H. Lucas. 1993. Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. J. Clin. Investig. 91:788-796.
    • (1993) J. Clin. Investig. , vol.91 , pp. 788-796
    • Granoff, D.M.1    Shackelford, P.G.2    Holmes, S.J.3    Lucas, A.H.4
  • 19
    • 0021711720 scopus 로고
    • Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
    • Griffiths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312:271-275.
    • (1984) Nature , vol.312 , pp. 271-275
    • Griffiths, G.M.1    Berek, C.2    Kaartinen, M.3    Milstein, C.4
  • 20
    • 0027212284 scopus 로고
    • Molecular size analysis of Haemophilus influenzae type b capsular polysaccharide
    • Hennessey, J. P., Jr., B. Bednar, and V. Manam. 1993. Molecular size analysis of Haemophilus influenzae type b capsular polysaccharide. J. Liquid Chromatogr. 16:1715-1729.
    • (1993) J. Liquid Chromatogr. , vol.16 , pp. 1715-1729
    • Hennessey J.P., Jr.1    Bednar, B.2    Manam, V.3
  • 21
    • 0027487153 scopus 로고
    • Rapid analysis of rearranged kappa light chain genes of circulating polysaccharide-specific B lymphocytes by means of immunomagnetic beads and the polymerase chain reaction
    • Hougs, L., T. Baringlon, H. O. Madsen, L. P. Ryder, and A. Svejgaard. 1993. Rapid analysis of rearranged kappa light chain genes of circulating polysaccharide-specific B lymphocytes by means of immunomagnetic beads and the polymerase chain reaction. Exp. Clin. Immunogenet. 10:141-151.
    • (1993) Exp. Clin. Immunogenet. , vol.10 , pp. 141-151
    • Hougs, L.1    Baringlon, T.2    Madsen, H.O.3    Ryder, L.P.4    Svejgaard, A.5
  • 22
    • 0032931928 scopus 로고    scopus 로고
    • The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells. Evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2
    • Hougs, L., L. Juul, H. J. Ditzel, C. Heilmann, A. Svejgaard, and T. Barington. 1999. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells. Evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2. J. Immunol. 162:224-237.
    • (1999) J. Immunol. , vol.162 , pp. 224-237
    • Hougs, L.1    Juul, L.2    Ditzel, H.J.3    Heilmann, C.4    Svejgaard, A.5    Barington, T.6
  • 23
    • 0020056871 scopus 로고
    • Cross-reactivity with Escherichia coll K100 in the human serum anticapsular antibody response to Haemophilus influenzae type b
    • Insel, R. A., and P. W. J. Anderson. 1982. Cross-reactivity with Escherichia coll K100 in the human serum anticapsular antibody response to Haemophilus influenzae type b. J. Immunol. 128:1267-1270.
    • (1982) J. Immunol. , vol.128 , pp. 1267-1270
    • Insel, R.A.1    Anderson, P.W.J.2
  • 25
    • 8544281674 scopus 로고    scopus 로고
    • Population studies of the human Vκ A18 gene polymorphism in Caucasians, Blacks, and Eskimos. New functional alleles and evidence for evolutionary selection for a more restricted antibody repertoire
    • Juul, L., L. Hougs, V. Andersen, P. Garred, L. P. Ryder, A. Svejgaard, B. Høgh, L. Lamm, B. Graugaard, and T. Barington. 1997. Population studies of the human Vκ A18 gene polymorphism in Caucasians, Blacks, and Eskimos. New functional alleles and evidence for evolutionary selection for a more restricted antibody repertoire. Tissue Antigens 49:595-604.
    • (1997) Tissue Antigens , vol.49 , pp. 595-604
    • Juul, L.1    Hougs, L.2    Andersen, V.3    Garred, P.4    Ryder, L.P.5    Svejgaard, A.6    Høgh, B.7    Lamm, L.8    Graugaard, B.9    Barington, T.10
  • 26
    • 0030835315 scopus 로고    scopus 로고
    • The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction. Frequent occurrence of features often assigned to autoimmunity
    • Juul, L., L. Hougs, V. Andersen, A. Svejgaard, and T. Barington. 1997. The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction. Frequent occurrence of features often assigned to autoimmunity. Clin. Exp. Immunol. 109:194-203.
    • (1997) Clin. Exp. Immunol. , vol.109 , pp. 194-203
    • Juul, L.1    Hougs, L.2    Andersen, V.3    Svejgaard, A.4    Barington, T.5
  • 28
    • 0344434639 scopus 로고    scopus 로고
    • Unpublished data
    • Lausen, B. 1998. Unpublished data.
    • (1998)
    • Lausen, B.1
  • 29
    • 0025642620 scopus 로고
    • A rapid method for isolating high quality plasmid DNA suitable for DNA sequencing
    • Jones, D. C. S., and J. P. Schofield. 1990. A rapid method for isolating high quality plasmid DNA suitable for DNA sequencing. Nucleic Acids Res. 18:7453-7464.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 7453-7464
    • Jones, D.C.S.1    Schofield, J.P.2
  • 30
    • 0027318265 scopus 로고
    • Age-dependent V region expression in the human antibody response to the Haemophilia influenzae type b polysaccharide
    • Lucas, A. H., F. H. Azmi, C. M. Mink, and D. M. Granoff. 1993. Age-dependent V region expression in the human antibody response to the Haemophilia influenzae type b polysaccharide. J. Immunol. 150:2056-2061.
    • (1993) J. Immunol. , vol.150 , pp. 2056-2061
    • Lucas, A.H.1    Azmi, F.H.2    Mink, C.M.3    Granoff, D.M.4
  • 31
    • 14844358870 scopus 로고
    • Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates
    • Lucas, A. H., and D. M. Granoff. 1995. Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates. J. Immunol. 154:4195-4202.
    • (1995) J. Immunol. , vol.154 , pp. 4195-4202
    • Lucas, A.H.1    Granoff, D.M.2
  • 32
    • 0026337715 scopus 로고
    • An idiotypic marker associated with a germ-line encoded K light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide
    • Lucas, A. H., R. J. Langley, D. M. Granoff, M. H. Nahm, M. Y. Kitamura, and M. G. Scott 1991. An idiotypic marker associated with a germ-line encoded K light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide. J. Clin. Investig. 88:1811-1818.
    • (1991) J. Clin. Investig. , vol.88 , pp. 1811-1818
    • Lucas, A.H.1    Langley, R.J.2    Granoff, D.M.3    Nahm, M.H.4    Kitamura, M.Y.5    Scott, M.G.6
  • 34
    • 0029164605 scopus 로고
    • Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus
    • Mattila, P. S., J. Schugk, H. Wu, and O. Mäkelä. 1995. Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus. Eur. J. Immunol. 25:2578-2582.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2578-2582
    • Mattila, P.S.1    Schugk, J.2    Wu, H.3    Mäkelä, O.4
  • 35
    • 0025964038 scopus 로고
    • Structure, function and properties of antibody binding sites
    • Mian, I. S., A. R. Bradwell, and A. J. Olson. 1991. Structure, function and properties of antibody binding sites. J. Mol. Biol. 217:133-151.
    • (1991) J. Mol. Biol. , vol.217 , pp. 133-151
    • Mian, I.S.1    Bradwell, A.R.2    Olson, A.J.3
  • 36
    • 0032400975 scopus 로고    scopus 로고
    • Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease
    • Nadel, B., A. Tang, G. Lugo, V. Love, G. Escuro, and A. J. Feeney. 1998. Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease. J. Immunol. 161:6068-6073.
    • (1998) J. Immunol. , vol.161 , pp. 6068-6073
    • Nadel, B.1    Tang, A.2    Lugo, G.3    Love, V.4    Escuro, G.5    Feeney, A.J.6
  • 37
    • 0029163536 scopus 로고
    • Functional capacities of clonal antibodies to Haemophilus influenzae type b polysaccharide
    • Nahm, M. H., K. H. Kim, P. Anderson, S. V. Hetherington, and M. K. Park. 1995. Functional capacities of clonal antibodies to Haemophilus influenzae type b polysaccharide. Infect. Immun. 63:2989-2994.
    • (1995) Infect. Immun. , vol.63 , pp. 2989-2994
    • Nahm, M.H.1    Kim, K.H.2    Anderson, P.3    Hetherington, S.V.4    Park, M.K.5
  • 38
    • 0023676076 scopus 로고
    • Model-building study of the combining sites of two antibodies to alpha (1→6)dextran
    • Padlan, E. A., and E. A. Kabat. 1988. Model-building study of the combining sites of two antibodies to alpha (1→6)dextran. Proc. Natl. Acad. Sci. USA 85: 6885-6889.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6885-6889
    • Padlan, E.A.1    Kabat, E.A.2
  • 39
    • 0025786156 scopus 로고
    • Distinct pattern of antibody reactivity with oligomeric or polymeric forms of the capsular polysaccharide of Haemophilus influenzae type b
    • Pillai, S., S. Ciciriello, M. Koster, and R. Eby. 1991. Distinct pattern of antibody reactivity with oligomeric or polymeric forms of the capsular polysaccharide of Haemophilus influenzae type b. Infect. Immun. 59:4371-4376.
    • (1991) Infect. Immun. , vol.59 , pp. 4371-4376
    • Pillai, S.1    Ciciriello, S.2    Koster, M.3    Eby, R.4
  • 40
    • 0028968094 scopus 로고
    • Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide
    • Pinchuk, G. V., C. Nottenburg, and E. C. B. Milner. 1995. Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide. Scand. J. Immunol. 41:324-330.
    • (1995) Scand. J. Immunol. , vol.41 , pp. 324-330
    • Pinchuk, G.V.1    Nottenburg, C.2    Milner, E.C.B.3
  • 41
    • 0031040659 scopus 로고    scopus 로고
    • Functional expression of the IGKV A18b gene and its idiotypic crossreactivity with the A2 variable region
    • Reason, D. C., and A. H. Lucas. 1997. Functional expression of the IGKV A18b gene and its idiotypic crossreactivity with the A2 variable region. Immunogenetics 45:343-344.
    • (1997) Immunogenetics , vol.45 , pp. 343-344
    • Reason, D.C.1    Lucas, A.H.2
  • 42
    • 0031014086 scopus 로고    scopus 로고
    • Human Fab fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression
    • Reason, D. C., T. C. Wagner, and A. H. Lucas. 1997. Human Fab fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression. Infect. Immun. 65:261-266.
    • (1997) Infect. Immun. , vol.65 , pp. 261-266
    • Reason, D.C.1    Wagner, T.C.2    Lucas, A.H.3
  • 45
    • 0027231544 scopus 로고
    • The immunoglobulin kappa locus: Polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals
    • Schäble, G., G. A. Rappold, W. Pargent, and H. G. Zachau. 1993. The immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum. Genet. 91:261-267.
    • (1993) Hum. Genet. , vol.91 , pp. 261-267
    • Schäble, G.1    Rappold, G.A.2    Pargent, W.3    Zachau, H.G.4
  • 46
    • 0025719511 scopus 로고
    • Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. the less frequently expressed VL are heterogeneous
    • Scott, M. G., D. L. Crimmins, D. W. McCourt, G. Chung, K. F. Schäble, R. Thiebe, E. M. Quenzel, H. G. Zachau, and M. H. Nahm. 1991. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous. J. Immunol. 147:4007-4913.
    • (1991) J. Immunol. , vol.147 , pp. 4007-4913
    • Scott, M.G.1    Crimmins, D.L.2    McCourt, D.W.3    Chung, G.4    Schäble, K.F.5    Thiebe, R.6    Quenzel, E.M.7    Zachau, H.G.8    Nahm, M.H.9
  • 47
    • 0024785847 scopus 로고
    • Gonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. a single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region
    • Scott, M. G., D. L. Crimmins, D. W. McCourt, I. Zocher, R Thiebe, H. G. Zachau, and M. H. Nahm. 1989. Gonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region. J. Immunol. 143:4110-4116.
    • (1989) J. Immunol. , vol.143 , pp. 4110-4116
    • Scott, M.G.1    Crimmins, D.L.2    McCourt, D.W.3    Zocher, I.4    Thiebe, R.5    Zachau, H.G.6    Nahm, M.H.7
  • 48
    • 0027016486 scopus 로고
    • The human antibody V region repertoire to the type b capsular polysaccharide of Haemophilus influenzae
    • Scott, M. G., H. G. Zachau, and M. H. Nahm. 1992. The human antibody V region repertoire to the type b capsular polysaccharide of Haemophilus influenzae. Int. Rev. Immunol. 9:45-55.
    • (1992) Int. Rev. Immunol. , vol.9 , pp. 45-55
    • Scott, M.G.1    Zachau, H.G.2    Nahm, M.H.3
  • 50
    • 0027227926 scopus 로고
    • Modeling study of antibody combining sites to (alpha 1-6)dextrans. Predictions of the conformational contribution of VL-CDR3 and J kappa segments to groove-type combining sites
    • Wang, D., J. M. Hubbard, and E. A. Kabat 1993. Modeling study of antibody combining sites to (alpha 1-6)dextrans. Predictions of the conformational contribution of VL-CDR3 and J kappa segments to groove-type combining sites. J. Biol. Chem. 268:20584-20589.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20584-20589
    • Wang, D.1    Hubbard, J.M.2    Kabat, E.A.3
  • 51
    • 0028345055 scopus 로고
    • Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated
    • Youngblood, K., L. Fruchter, G. Ding, J. Lopez, V. Bonagura, and A. Davidson. 1994. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J. Clin. Investig. 93:852-861.
    • (1994) J. Clin. Investig. , vol.93 , pp. 852-861
    • Youngblood, K.1    Fruchter, L.2    Ding, G.3    Lopez, J.4    Bonagura, V.5    Davidson, A.6


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