Population studies of the human Vκ A18 gene polymorphism in Caucasians, blacks and Eskimos: New functional alleles and evidence for evolutionary selection of a more restricted antibody repertoire

Tissue Antigens

Volumn 49, Issue 6, 1997, Pages 595-604

  Juul, L ^a   Hougs, L ^a   Andersen, V ^a   Garred, P ^a   Ryder, L ^a   Svejgaard, A ^a   Hogh B ^b   Lamm, L ^c   Graugaard, B ^a   Barington, T ^a  

^a Rigshospitalet   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antibody repertoire; Evolution; Gene polymorphism; Kappa immunoglobulin gene

Indexed keywords

ALLELE; ARTICLE; CAUCASIAN; DNA POLYMORPHISM; ESKIMO; GENE FREQUENCY; GENE SEQUENCE; GREENLAND; HUMAN; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; MOZAMBIQUE; NEGRO; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 8544281674     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.1997.tb02807.x     Document Type: Article

References (28)

1. Schäble KF, Zachau HG. The variable genes of the human immunoglobulin kappa locus. Biol Chem Hoppe-Seyler 1993: 374: 1001-22.
2. Atkinson MJ, Cowan MJ, Feeney AJ. New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism. Immunogenetics 1996: 44: 115-20.
3. Schäble K, Thiebe R, Flugel A, Meindl A, Zachau HG. The human immunoglobulin kappa locus: pseudogenes, unique and repetitive sequences. Biol Chem Hoppe-Seyler 1994: 375: 189-99.
4. Cox JP, Tomlinson IM, Winter G. A directory of human germ-line V kappa segments reveals a strong bias in their usage. Eur J Immunol 1994: 24: 827-36.
5. Lucas AH, Langley RJ, Granoff DM, Nahm MH, Kitamura MY, Scott MG. An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide. J Clin Invest 1991: 88: 1811-8.
6. Lautner Rieske A, Huber C, Meindl A et al. The human immunoglobulin kappa locus. Characterization of the duplicated A regions. Eur J Immunol 1992: 22: 1023-9.
7. Garred P, Madsen HO, Kurtzhals JA et al. Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans. Eur J Immunogenet 1992: 19: 403-12.
8. Høgh B, Thompson R, Hetzel C et al. Specific and non-specific responses to Plasmodium falciparum blood-stage parasites and observations on the gametocytemia in school children living in a malaria-endemic area of Mozambique. Am J Trop Med Hyg 1995: 52: 50-9.
9. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988: 16: 1215.
10. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
11. Jones DS, Schofield JP. A rapid method for isolating high quality plasmid DNA suitable for DNA sequencing. Nucleic Acids Res 1990: 18: 7463-4.
12. Jansen R, Ledley FD. Disruption of phase during PCR amplification and cloning of heterozygous target sequences. Nucleic Acids Res 1990: 18: 5153-6.
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987: 162: 156-9.
14. Tindall KR, Kunkel TA. Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry 1988: 27: 6008-13.
15. Pargent W, Schable KF, Zachau HG. Polymorphisms and haplotypes in the human immunoglobulin kappa locus. Eur J Immunol 1991: 21: 1829-35.
16. Schaible G, Rappold GA, Pargent W, Zachau HG. The immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum Genet 1993: 91: 261-7.
17. Kofler R, Geley S, Kofler H, Helmberg A. Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol Rev 1992: 128: 5-21.
18. Högbom E, Magnusson AC, Leanderson T. Functional modularity in the SP6 kappa promoter. Nucleic Acids Res 1991: 19: 4347-54.
19. Cavall-Sforza LL, Piazza A, Menozzi P, Mountain J. Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci U S A 1988: 85: 6002-6.
20. Klein U, Küppers R, Rajewsky K. Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur J Immunol 1993: 23: 3272-7.
21. Bijlmer HA, van Alphen L. A prospective, population-based study of Haemophilus influenzae type b meningitis in The Gambia and the possible consequences. J Infect Dis 1992: 165 (suppl 1): S29-32.
22. Scott MG, Crimmins DL, McCourt DW et al. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous. J Immunol 1991: 147: 4007-13.
23. Scott MG, Tarrand JJ, Crimmins DL et al. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. II. IgG antibodies contain VH genes from a single VH family and VL genes from at least four VL families. J Immunol 1989: 143: 293-8.
24. Pinchuk GV, Nottenburg C, Milner EC. Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide. Scand J Immunol 1995: 41: 324-30.
25. Adderson EE, Shackelford PG, Insel RA et al. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations. J Clin Invest 1992: 89: 729-38.
26. Adderson EE, Shackelford PG, Quinn A et al. Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenzae type b capsular polysaccharide. Pediatr Res 1993: 33: 307-11.
27. Lucas AH, Larrick JW, Reason DC. Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide. Infect Immun 1994: 62: 3873-80.
28. Reason DC, Lucas AH. Functional expression of the IGKV A18b gene and its idiotypic crossreactivity with the A2 variable region. Immunogenetics (in press).