Enduring changes in Purkinje cell electrophysiology following transient exposure to AMPA: Correlates to dark cell degeneration

Neuroscience Research

Volumn 33, Issue 2, 1999, Pages 155-162

  Strahlendorf, Jean C ^a   Strahlendorf, Howard K ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

AMPA; Electrophysiology; Excitatory amino acids; Glutamate; Neurotoxicity; Purkinje cells

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; ION CURRENT; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PURKINJE CELL; RAT;

EID: 0032952903     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(98)00126-6     Document Type: Article

References (24)

1. Audinat E., Knopfel T., Gahwiler B.H. Responses to excitatory amino acids of Purkinje cells and neurones of the deep nuclei in cerebellar slice cultures. J. Physiol. 430:1990;297-313.
2. Beal M.F. Mechanisms of excitotoxicity in neurologic diseases. FASEB J. 6:1992;3338-3344.
3. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J. Neurosci. 14:1994;187-197.
4. Chen Q.X., Perkins K.L., Choi D.W., Wong R.K.S. Secondary activation of a cation conductance is responsible for NDMA toxicity in acutely isolated hippocampal neurons. J. Neurosci. 17:1997;4032-4036.
5. Choi D.W., Koh J., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8:1988;185-196.
6. Filipkowski R.K., Hetman M., Kaminska B., Kaczmarek L. DNA fragmentation in rat brain after intraperitoneal administration of kainate. Neuroreport. 5:1994;1538-1540.
7. Garthwaite J., Garthwaite G. Excitatory amino acids and neuronal plasticity. Ben-Ari Y. Mechanisms of Excitatory Amino Acid Neurotoxicity in Rat Brain Slices. 1990;505-518 Plenum Press, New York.
8. Garthwaite G., Garthwaite J. AMPA neurotoxicity in rat cerebellar and hippocampal slices: histological evidence for three mechanisms. Eur. J. Neurosci. 3:1991;715-728.
9. Garthwaite G., Garthwaite J. Mechanisms of AMPA neurotoxicity in rat brain slices. Eur. J. Neurosci. 3:1991;729-736.
10. Garthwaite J., Garthwaite G., Hajos F. Amino acid neurotoxicity: relationship to neuronal depolarization in rat cerebellar slices. Neuroscience. 18:1986;449-460.
11. Krupa M., Crepel F. Transient sensitivity of rat cerebellar Purkinje cells to N-methyl-D-asparate during development. A voltage clamp study in in vitro slices. Eur. J. Neurosci. 2:1990;312-316.
12. Llano I., Marty A., Johnson J.W., Ascher P., Gahwiler B.H. Patch-clamp recording of amino acid-activated responses in 'organotypic' slice cultures. Proc. Natl. Acad. Sci. USA. 85:1988;3221-3225.
13. Llano I., Marty A., Armstrong C.M., Konnerth A. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J. Physiol. 434:1991;183-213.
14. Lysko P.G., Cox J.A., Vigano M.A., Henneberry R.C. Excitatory amino acid neurotoxicity at the N-methyl-D-asparate receptor in cultured neurons: pharmacological characterization. Brain Res. 499:1989;258-266.
15. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1990;379-387.
16. Michaels R.L., Rothman S.M. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10:1990;283-292.
17. Nellgard B., Wieloch T.J. Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. Cereb. Blood Flow Metab. 12:1992;2-11.
18. Pollard H., Charriaut-Marlangue C., Cantagrel S., Represa A., Robain O., Moreau J., Ben-Ari Y. Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience. 63:1994;7-18.
19. Portera-Cailliau C., Price D.L., Martin L.J. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. J. Comp. Neurol. 378:1997;88-104.
20. Rosenmund C., Legendre P., Westbrook G.L. Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats. J. Neurophysiol. 68:1992;1901-1905.
21. Sombati S., Coulter D.A., DeLorenzo R.J. Neurotoxic activation of glutamate receptors induces an extended neuronal depolarization in cultured hippocampal neurons. Brain Res. 566:1991;316-319.
22. Strahlendorf J.C., Acosta S., Strahlendorf H.K. Diazoxide and cyclothiazide convert AMPA-induced dark cell degeneration of Purkinje cells to edematous damage in the cerebellar slice. Brain Res. 729:1996;197-204.
23. Strahlendorf J.C., Brandon T., Miles R., Strahlendorf H.K. AMPA receptor-mediated alterations of intracellular calcium homeostasis in rat cerebellar Purkinje cells in vitro: Correlates to dark cell degeneration. Neurochem. Res. 23:1998;1355-1362.
24. Zorumski C.F., Thio L.L. Properties of vertebrate glutamate receptors: calcium mobilization and desensitization. Prog. Neurobiol. 39:1992;295-336.