Lack of association of the dopamine D4 receptor gene polymorphism with alcoholism in a Brazilian population

Addiction Biology

Volumn 4, Issue 2, 1999, Pages 203-207

  Roman, Tatiana ^a   Bau, Claiton H D ^a   Almeida, Silvana ^a   Hutz, Mara H ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; BASE PAIRING; BRAZIL; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RACE DIFFERENCE; TANDEM REPEAT;

EID: 0032952653     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/13556219971713     Document Type: Article

References (22)

1. Carmichael FJ, Israel Y. Effects of ethanol on neurotransmitter release by rat brain cortical slices. J Pharmacol Exp Ther 1975;193:824-34.
2. Fadda R, Argiolas A, Melis MR, Serra G, Gessa GL. Differential effect of acute and chronic ethanol on dopamine metabolism in frontal cortex, caudate nucleus and substantia nigra. Life Sci 1980;27:979-86.
3. Koob FG, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science 1988; 242:715-23.
4. Noble EP. Alcoholism and the dopaminergic system: A review. Addict Biol 1996;1:333-48.
5. Van Tol HHM, Bunzow JR, Guan HC et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991;350:610-14.
6. Van Tol HHM, Wu CM, Guan HC et al. Multiple dopamine D4 receptor variants in the human population. Nature 1992;358:149-52.
7. George SR, Cheng R, Nguyen T, Israel Y, O'Dowd BF. Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism. Biochem Biophys Res Commun 1993;196:107-14.
8. Adamson MD, Kennedy J, Petronis A et al. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Am J Med Genet (Neuropsychiatr Genet) 1995;60:199-205.
9. Chang FM, Ko HC, Lu RB, Pakstis AJ, Kidd KK. The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: six polymorphisms tested separately and as haplotypes. Biol Psychiatr 1997;41:394-405.
10. Parsian A, Chakraverty S, Fisher L, Cloninger CR. No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism. Am J Med Genet (Neuropsychiatr Genet) 1997;74:281-5.
11. Muramatsu T, Higuchi S, Murayama M, Matsushita S, Hayashida M. Association between alcoholism and the dopamine D4 receptor gene. J Med Genet 1996;33:113-15.
12. Chang FM, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 1996;98:91-101.
13. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edn revised. Washington, DC: American Psychiatric Association Press; 1987.
14. Saranson IG, Johnson JH, Siegel JM. Assessing the impact of life changes: development of the life experiences survey. J Consult Clin Psychol 1978; 46:932-46.
15. Cloninger CR. Neurogenetic adaptative mechanisms in alcoholism. Science 1987;236:410-16.
16. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
17. Lichter JB, Barr CL, Kennedy JL, Van Tol HHM, Kidd KK, Livak KJ. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993;2:767-73.
18. Babor TF, Hofmann M, Delboca FK et al. Types of alcoholics, 1. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatr 1992;49:599-608.
19. Bau CHD, Salzano FM. Alcoholism in Brazil - the role of personality and susceptibility to stress. Addiction 1995;90:693-8.
20. Odelberg SJ, Plactke R, Eldridge JR et al. Characterization of eight VNTR loci by agarose gel electrophoresis. Genomics 1989;5:915-24.
21. Roff DA, Bentzen P. The statistical analysis of mitochondrial DNA polymorphisms: chi-square and the problem of small samples. Mol Biol Evol 1989;6:539-45.
22. Salzano FM, Freire-Maia N. Problems in human biology. A study of Brazilian populations. Detroit: Wayne State University Press; 1970.