Frequent amplification of C-erbB2 (HER-2/Neu) oncogene in cervical carcinoma as detected by non-fluorescence in situ hybridization techniques on paraffin sections

Oncology

Volumn 56, Issue 1, 1999, Pages 83-87

  Sharma, A ^a   Pratap, M ^a   Malhotra Sawhney, V ^a   Khan, I U ^a   Bhambhani, S ^a   Mitra, A B ^a  

^a MAULANA AZAD MEDICAL COLLEGE   (India)

Author keywords

Amplification; C erbB2; In situ hybridization; Non fluorescence

Indexed keywords

PARAFFIN;

ARTICLE; FEMALE; GENE AMPLIFICATION; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTERMETHOD COMPARISON; MICROSCOPY; ONCOGENE C ERB; PRIORITY JOURNAL; SOUTHERN BLOTTING; SQUAMOUS CELL; TUMOR CELL; UTERINE CERVIX CARCINOMA;

CARCINOMA, SQUAMOUS CELL; FEMALE; GENE AMPLIFICATION; GENES, ERBB-2; HUMANS; IN SITU HYBRIDIZATION; NEOPLASM STAGING; PARAFFIN; RECEPTOR, ERBB-2; UTERINE CERVICAL NEOPLASMS;

EID: 0032950875     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000011934     Document Type: Article

References (17)

1. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, Pres MF: Studies of the Her-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:702-712.
2. Gusterson BA, Machin LG, Gullick WJ, Gibbs NM, Powels TJ, Price P. Mckinna A, Harrison S: Immunohistochemical distribution of c-erbB-2 in infiltrating and in-situ breast cancer. Int J Cancer 1988;42:842-845.
3. Kury F, Sliutz G. Schemper M, Reiner G, Reiner A, Jakesz R, Wrba F, Zeillinger R, Knogler W, Huber H, Spona J: HER-2 oncogene amplification and overall survival of breast carcinoma patients. Eur J Cancer 1990; 26:946-949.
4. Yokota J, Yamamoto T, Miyajima N, Toyoshima K, Nomura N, Sakamoto H, Yoshida T, Terada M, Sugimura T: Genetic alterations of the C-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the V-erb A homologue. Oncogene 1988;2:283-287.
5. Freeman MR, Washecka R, Chung LW: Aberrant expression of epidermal growth factor receptor and HER-2(erb-2) messenger RNAs in human renal cancers. Cancer Res 1989;49: 6221-6225.
6. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
7. Fernandez JL, Goyanes V, Fernandez CL, Buno I, Gosalvez J: Quantitation of c-erbB-2 gene amplification in breast cancer cells using fluorescence in situ hybridization and digital image analysis. Cancer Genet Cytogenet 1996; 86:18-21.
8. Kihana T, Tsuda H, Teshima S, Kiyoaki N, Tsugane S, Sonoda T, Matsuura S, Hirohashi S: Prognostic significance of the overexpression of C-erbB-2 protein in adenocarcinoma of the uterine cervix. Cancer 1994;73:148-153.
9. Pinion SB, Kennedy JH, Miller RW, MacLean AB: Oncogene expression in cervical intraepithelial neoplasia and invasive cancer of cervix. Lancet 1991;337:819-820.
10. Mitra AB, Murty VVVS, Pratap M, Sodhani P, Chaganti RSK: erbB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix. Cancer Res 1994;54: 637-639.
11. Kallioniemi OP, Kallioniemi A, Kurisu W, Thor A, Chen LC, Smith HS, Waldman FM, Pinkel D, Gray JW: erbB2 amplification in breast cancer analysed by fluorescence in-situ hybridization. Proc Natl Acad Sci USA 1992; 89:5321-5325.
12. Zhang X, Silva E, Gershenson D, Hung MC: Amplification and rearrangement of c-erbB proto-oncogene in cancer of human female genital tract. Oncogene 1989;4:985-989.
13. Van de Vijver MJ, Mooi WJ, Peterse JL, Nurse R: Amplification and overexpression of the neu oncogene in human breast carcinomas. Eur J Surg Oncol 1988;14:111.
14. Prost S, Le MG, Doue RS, Ahomadegbe JC, Spielmann M, Guerin M, Riou G: Association of c-erbB2-gene amplification with poor prognosis in noninflammatory breast carcinomas but not in carcinomas of the inflammatory type. Int J Cancer 1994;58:763-768.
15. Lofts FJ, Gullick WJ: C-erbB2 amplification and overexpression in human tumors. Cancer Treat Res 1992;61:161-179.
16. Descotes F, Pavy JJ, Adessi GL: Human breast cancer: Correlation study between HER-2/Neu amplification and prognostic factors in an unselected population. Anticancer Res 1993;13: 119-124.
17. Tsuda H, Hirohashi S, Shimosato Y, Tanaka Y, Hiroto T, Tsugane S, Shirashi M, Toyoshima K, Yamamoto T, Terada M: Immunohistochemical study on overexpression of C-erbB2 protein in human breast cancer: Its correlation with gene amplification and long-term survival of patients. Jpn J Cancer Res 1990;81:327-332.