Risk factors for detecting germline BRCA1 and BRCA2 founder mutations in Ashkenazi Jewish women with breast or ovarian cancer

Journal of Medical Genetics

Volumn 36, Issue 5, 1999, Pages 369-373

  Hodgson, Shirley V ^a   Heap, Elizabeth ^a   Cameron, June ^a   Ellis, David ^a   Mathew, Christopher G ^a   Eeles, Rosalind A ^a   Solomon, Ellen ^a   Lewis, Cathryn M ^b  

^a GUY S HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Ashkenazi Jewish; BRCA1; BRCA2; Breast cancer

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GENETICS; CANCER RISK; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; FOUNDER EFFECT; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; JEW; MAJOR CLINICAL STUDY; ONCOGENE; ONSET AGE; OVARY CANCER; POPULATION GENETICS; PREDICTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR;

ADULT; AGED; AGED, 80 AND OVER; BRCA2 PROTEIN; BREAST NEOPLASMS; FEMALE; FOUNDER EFFECT; GENES, BRCA1; GENETIC SCREENING; GERM-LINE MUTATION; HUMANS; JEWS; MIDDLE AGED; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; RISK FACTORS; TRANSCRIPTION FACTORS;

EID: 0032946943     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Szabo CI, King MC. Population genetics of BRCA1 and BRCA2. Am J Hum Genet 1997;60:1013-20.
2. Offit K, Gilewski T, McGuire P, et al. Germline BRCA1 185delAG mutations in Jewish women with breast cancer. Lancet 1996;347:1643-5.
3. Tonin P, Weber B, Offit K, et al. Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med 1996;2:1179-83.
4. Abeliovich D, Kaduri I, Lerer I, et al. The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of early onset breast cancer patients among Ashkenazi women. Am J Hum Genet 1997;60:505-14.
5. Struewing JP Albeliovich D, Peretz T, et al. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nat Genet 1995;14:185-7.
6. Muto MG, Cramer DW, Tangir J, Berkowitz R, Mok S. Frequency of the BRCA1 185delAG mutation among Jewish women with ovarian cancer and matched population controls. Cancer Res 1996;56:1250-2.
7. Levy-Lahad E, Catane R, Eisenberg S, et al. Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families. Am J Hum Genet 1997;60:1059-67.
8. Egan KM, Newcomb PA, Longnecker MP, et al. Jewish religion and risk of breast cancer. Lancet 1996;347:1645-6.
9. Robson M, Dabney MK, Rosenthal G, et al. Prevalence of recurring BRCA mutations among Ashkenazi Jewish women with breast cancer Genet Testing 1997;1:47-51.
10. Lalloo F, Cochrane S, Bulman B, et al. An evaluation of common breast cancer gene mutations in a population of Ashkenazi Jews. J Med Genet 1998;35:10-12.
11. Shattuck-Eidens D, Oliphant A, McClure M. BRCA1 sequence analysis in women at high risk for susceptibility mutations: risk factor analysis and implications for genetic testing. J AMA 1997;278:1242-50.
12. Schubert EL, Mefford HC, Dann JL, et al. BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and ovarian cancer. Genet Testing 1997;1:41-6.
13. Bar Sade RB, Kruglikova A, Modan B, et al. The 185delAG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim. Hum Mol Genet 1998;7:801-6.
14. Struewing JP, Hartge P, Wacholder S, et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 1997;336:1401-8.
15. Ford D, Easton DF, Bishop DT, et al. Risks of cancer in BRCA1-mutation carriers. Lancer 1994;343:692-5.
16. Wooster R, Neuhausen SL, Mangion J, et al. Localisation of a breast cancer susceptibility gene BRCA2 to chromosome 13q12-q13. Science 1994;265:2088-90.
17. Fitzgerald MG, MacDonald DJ, Krainer M, et al. Germline BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 1996;334:143-9.
18. Wooster R, Bignell G, Lancaster J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995;378:789-92.