Mifepristone and misoprostol

Current Obstetrics and Gynaecology

Volumn 9, Issue 1, 1999, Pages 29-33

  Ho, P C ^a   Ngai, S W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

GEMEPROST; METHOTREXATE; MIFEPRISTONE; MISOPROSTOL; PROSTAGLANDIN; WATER;

CONTRACEPTION; DRUG TOXICITY; FEMALE; HUMAN; INTRAVAGINAL DRUG ADMINISTRATION; LABOR INDUCTION; LICENSING; ORAL DRUG ADMINISTRATION; PREGNANCY TERMINATION; REVIEW; SECOND TRIMESTER ABORTION; UTERINE CERVIX DILATATION; VACUUM ASPIRATION; VAGINA BLEEDING;

EID: 0032944853     PISSN: 09575847     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-5847(99)90070-7     Document Type: Article

References (43)

1. Cadepond F, Ulmann A, Baulieu EE. RU486 (mifepristone): mechanisms of action and clinical uses. Annu Rev Med 1997; 48: 129-156
2. Lahteenmaki P, Heikinheimo O, Croxatto H et al. Pharmacokinetics and metabolism of RU486. J Steroid Biochem 1987; 27: 859-863
3. Norman JE, Thong KJ, Baird DT. Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone. Lancet 1991; 338: 1233-1237
4. Zieman M, Fong SK, Benowitz NL et al. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol 1997; 90: 88-91
5. Tang GWK, Lau OWK, Yip P. Further acceptability evaluation of RU486 and ONO 802 as abortifacient agents in a Chinese population. Contraception 1993; 48: 267-276
6. Couzinet B, Strat NL, Ulmann A et al. Termination of early pregnancy by the progesterone antagonist RU486 (mifepristone). N Engl J Med 1986; 315: 1565-1570
7. Bygdeman M, Swahn ML. Progesterone receptor blockage. Effect on uterine contractility and early pregnancy. Contraception 1985; 32: 45-51
8. Silvestre L, Dubois C, Renault M et al. Voluntary interruption of pregnancy with mifepristone (RU486) and a prostaglandin analogue. N Engl J Med 1990; 322: 645-648
9. Urquhart DR, Templeton AA, Shinewi F et al. The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study-final results. Contraception 1997; 55: 1 5
10. World Health Organization. Termination of pregnancy with reduced doses of mifepristone. Br Med J 1993; 307: 532-537
11. Baird DT, Sukcharoen N, Thong KJ. Randomized trial of misoprostol and cervagem in combination with a reduced dose of mifepristone for induction of abortion. Hum Reprod 1995; 10: 1521-1527
12. El-Refaey H, Rajasckar D, Abdalla M et al. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med 1995; 332: 983-987
13. Koopersmith TB, Mishell Jr DR. The use of misoprostol for termination of early pregnancy. Contraception 1996; 53: 237-242
14. Bugalho A, Faundes A, Jamisse L et al. Evaluation of the effectiveness of vaginal misoprostol to induce first trimester abortion. Contraception 1996; 53: 243-246
15. Carbonell JLL, Varela L, Velazco A et al. The use of misoprostol for termination of early pregnancy. Contraception 1997; 55: 165-168
16. Creinin MD, Darney PH. Methotrexate and misoprostol for early abortion. Contraception 1993; 48: 339-348
17. Creinin MD. Oral methotrexate and vaginal misoprostol for early abortion. Contraception 1996; 54: 15-18
18. Ho PC, Ma HK. Termination of pregnancy with sulprostone and mifepristone: a randomized double-blind placebo-controlled trial. Contraception 1993; 47: 123-129
19. Ho PC, Tsang SSK, Ma HK. Reducing the induction-to-abortion interval in termination of second trimester pregnancies: a comparison of mifepristone with laminaria tent. Br J Obstet Gynaecol 1995; 102: 684-651
20. Ho PC, Chan YF, Lau W. Misoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone: a randomized comparative trial. Contraception 1996; 53: 281-283
21. Ho PC, Ngai SW, Liu KL et al. Vaginal misoprostol compared with oral misoprostol in termination of second trimester pregnancy. Obstet Gynecol 1997; 90: 735-738
22. Jain JK, Mishell R. A comparison of intravaginal misoprostol with prostaglandin E2 for termination of second-trimester pregnancy. The New Engl J Med 1994; 331: 290-293
23. Wong KS, Ngai CSW, Wong AYK et al. Vaginal misoprostol compared with vaginal gemeprost in termination of second trimester pregnancy: a randomized trial. Contraception 1998; 58:207-210
24. Ho PC. Termination of pregnancy between 9 and 14 weeks. In: Baird DT, Grimes DA, van Look PFA (eds) Modern methods of inducing abortion. Blackwell Science 1995; 54-69
25. 2α methyl ester for pre-operative cervical dilatation. Contraception 1981; 23: 251-257
26. World Health Organization Task Force on Post-ovulatory Methods for Fertility Regulation. The use of mifepristone (RU486) for cervical preparation in first trimester pregnancy termination by vacuum aspiration. Br J Obstet Gynaecol 1990; 97: 260-266
27. El-Refaey H, Calder L, Wheatley DN et al. Cervical priming with prostaglandin El analogues, misoprostol and gemeprost. Lancet 1994; 343: 1207-1209
28. Ngai SW, AuYeung KC, Lao T et al. Oral misoprostol versus vaginal gemeprost for cervical dilatation prior to vacuum aspiration in women in the sixth to twelfth week of gestation. Contraception 1995; 51: 347-350
29. Henshaw RC, Templeton AA. Pre-operative cervical preparation before first trimester vacuum aspiration: a randomized controlled comparison between gemeprost and mifepristone (RU486). Br J Obstet Gynaecol 1991; 98: 1025-1030
30. Ngai SW, AuYeung KC, Lao T et al. Oral misoprostol versus mifepristone for cervical dilatation before vacuum aspiration in first trimester nulliparous pregnancy: a double blind prospective randomized study. Br J Obstet Gynaecol 1996; 103: 1120-1123
31. Lawrie A, Penney G, Templeton A. A randomized comparison of oral and vaginal misoprostol for cervical priming before suction termination of pregnancy. Br J Obstet Gynaecol 1996; 103: 1117-1119
32. Ngai SW, Chan YM, Liu KL et al. Oral misoprostol for cervical priming in non-pregnant women. Human Reprod 1997; 12: 2373-2375
33. Refaey HE, Hinshaw K, Henshaw et al. Medical management of missed abortion and anembryonic pregnancy. Br Med J 1992; 305: 1399
34. Chung TKH, Cheung LP, Leung TY et al. Misoprostol in the management of spontaneous abortion. Br J Obstet Gynaecol 1995; 102: 832-835
35. Creinin MD, Moyer R, Guido R. Misoprostol for medical evacuation of early pregnancy failure. Obstet Gynecol 1997; 89(5 part 1): 768-772
36. Frydman R, Lelaidier C, Baton-Saint-Mleux C et al. Labor induction in women at term with mifepristone (RU486): a double-blind, randomized, placebo-controlled study. Obstet Gynecol 1992; 80(6): 972-975
37. Margulies M, Campos-Pertez G, Voto LS. Misoprostol to induce labor [letter]. Lancet 1992; 339: 64
38. Ngai SW, To WK, Lao T et al. Cervical priming with oral misoprostol in pre-labor rupture of membranes at term. Obstet Gynecol 1996; 87: 923-927
39. Sanchez-Ramos L, Kaunitz AM, Wears R et al. Misoprostol for cervical ripening and labor induction. Obstet Gynecol 1997; 89: 633-642
40. Glasier AK, Thong J, Dewar et al. Mifepristone (RU486) compared with high-dose estrogen and progestogen for emergency postcoital contraception. N Engl J Med 1992; 327: 1041-1044
41. Webb AMC, Russel J, Elstein M. Comparison of Yuzpe regimen, danazol and mifepristone (RU486) in oral postcoital contraception. Br Med J 1992; 305: 927-931
42. World Health Organization. Antiprogestogen-only emergency contraception (mifepristone). Annual Technical Report 1996; 46-47
43. Royal College of Obstetricians and Gynaecologists. Induced Abortion. Guideline No. 11; July 1997