Oral misoprostol versus mifepristone for cervical dilatation before vacuum aspiration in first trimester nulliparous pregnancy: A double blind prospective randomised study

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 103, Issue 11, 1996, Pages 1120-1123

  Ngai, Suk Wai ^a   Au Yeuug, Kam Chuen ^a   Lao, Terence ^a   Ho, Pak Chung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; MISOPROSTOL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FIRST TRIMESTER PREGNANCY; HUMAN; NULLIPARA; ORAL DRUG ADMINISTRATION; PREGNANCY TERMINATION; PRIORITY JOURNAL; UTERINE CERVIX DILATATION; VACUUM EXTRACTION;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTION, INDUCED; ADMINISTRATION, ORAL; ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MIFEPRISTONE; MISOPROSTOL; PARITY; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROSPECTIVE STUDIES; TABLETS; UTERINE HEMORRHAGE; VACUUM EXTRACTION, OBSTETRICAL;

EID: 0029804169     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1996.tb09594.x     Document Type: Article

References (14)

1. Beric BM, Kupresanin M. Vacuum aspiration, using pen-cervical block, for legal abortion as an outpatient procedure up to the 12th week of pregnancy. Lancet 1972; 2:619–621.
2. Wright CSW, Campell S, Beazley J. Second trimester abortion after vaginal termination of pregnancy. Lancet 1972; 1: 1278–1279.
3. Johnson N. Intracervical tests: usage and mode of action. Obstet Gynecol Surv 1989; 44:410–420.
4. Liang ST, Woo JSK, Tang GWK. Ultrasonic localisation of a displaced laminaria tent. Am J obstet Gynecol 1983; 146:410–420.
5. Ho PC, Liang ST, Tang GWK, Ma HK. Pre-operative cervical dilatation in termination of first trimester pregnancies using 16,16-methyl-trans-PGE methyl ester vaginal pessaries. Contraception 1983; 27: 339–346.
6. Durlot F, Dubois C, Brunerie J et al. Efficacy of progesterone antagonist RU486 (mifepristone). N Engl J Med 1988; 315: 1565–1570.
7. World Health Organisation. The use of mifepristone (RU486) for cervical preparation in first trimester termination by vacuum extraction. Br J Obstet Gynaecol 1990; 97: 260–266.
8. Henshaw RC, Templeton AA. Pre-operative cervical preparation before first trimester vacuum aspiration: randomised controlled comparison between gemeprost and mifepristone. Br J Obstet Gynaecol 1991; 98: 1025–1030.
9. Norman JE, Thong KJ, Baird DT. Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone. Lancet 1991; 338:1233–1236.
10. Ngai SW, Tang OS, Lao T, Ho PC. Oral misoprostol versus placebo for cervical dilatation before vacuum aspiration in first trimester prignancy. Hum Reprod 1995; 10:1220–1222.
11. Ngai SW, Au, Yeung KC, Lao T, Ho PC. Oral misoprostol versus vaginal gemeprost for cervical dilatation prior to vacuum aspiration in women in the sixth to twelfth week of gestation. Contraception 1995; 51: 335–337.
12. Meinert CL. Clinical Trials: Design, Conduct and Analysis. Oxford : Oxford University Press, 1986: 96–101.
13. El-Refaey H, Calder L, Wheatley DN, Templeton A. Cervical priming with prostaglandin E, analogues, misoprostol and gemeprost. Lancet 1994;343:1207–1209.
14. Shepard TH. Mobius syndrome after misoprostol: A possible teratogenic mechanism [letter]. Lancet 1995; 346:780.