Detection of ozone-induced DNA single strand breaks in murine bronchoalveolar lavage cells acutely exposed in vivo

Inhalation Toxicology

Volumn 11, Issue 4, 1999, Pages 331-341

  Haney Jr , Joseph T ^a   Connor, Thomas H ^a   Li, Li ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MURINAE;

EID: 0032944565     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583799197122     Document Type: Article

References (34)

1. Anderson, D., Yu, T. W., Phillips, B. J., and Schmezer, P. 1994. The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the comet assay. Mutat. Res. 307:261-271.
2. Anderson, D., Yu, T. W., and Schmezer, P. 1995. An investigation of the DNA-damaging ability of benzene and its metabolites in human lymphocytes, using the comet assay. Environ. Mol. Mutagen. 26:305-314.
3. Baker, M., and He, S. 1991. Elaboration of cellular DNA breaks by hydroperoxides. Free Radical Biol. Med. 11:563-572.
4. Calderón-Garcidueñas, L., and Roy-Ocotia, G. 1993. Nasal cytology in southwest metropolitan Mexico City inhabitants: A pilot intervention study. Environ. Health Perspect. 101:138-144.
5. Calderón-Garcidueñas, L., Osnaya-Brizuela, N., Ramirez-Martinez, L., and Villarreal-Calderón, A. 1996. DNA strand breaks in human nasal respiratory epithelium are induced upon exposure to urban pollution. Environ. Health Perspect. 104:160-168.
6. Collins A. R., Dušinká, M., Gedik, C. M., and Štětina, R. 1996. Oxidative damage to DNA: Do we have a reliable biomarker? Environ. Health Perspect. 104(suppl. 3):465-469.
7. Devlin, B., McDonnell, W. E., Mann, R., Becker, S., House, D. E., Schreinemachers, D., and Koren, H. S. 1991. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am. J. Respir. Cell Mol. Biol. 4:72-81.
8. Fairbairn, D. W., Carnahan, K. G., Thwaits, R. N., Grigsby, R. V., Holyoak, G. R., and O'Neill, K. L. 1994. Detection of apoptosis induced DNA cleavage in scrapie infected sheep brain. FEMS Microbiol. Lett. 115:341-346.
9. Fairbairn, D. W., Olive, P. L., and O'Neill, K. L. 1995. The comet assay, a comprehensive review. Mutat. Res. 339:37-59.
10. Feig, D. I., Reid, T. M., and Loeb, L. A. 1994. Reactive oxygen species in tumorigenesis. Cancer Res. (Suppl.) 54:1890s-1894s.
11. Ferng, S. F., Castro, C. E., Afifi, A. A., Bermudez, E., and Mustafa, M. G. 1997. Ozone-induced DNA strand breaks in guinea pig tracheobronchial epithelial cells. J. Toxicol. Environ. Health 51:353-367.
12. Gabrielson, E. W., Yu, X. Y., and Spannhake, E. W. 1994. Comparison of the toxic effects of hydrogen peroxide and ozone on cultured human bronchial cells. Environ. Health Perspect. 102:972-974.
13. Gedik, C. M., Ewen, S. W. B., and Collins, A. R. 1992. Single cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. Int. J. Radiat. Biol. 62:313-320.
14. Imlay, J. A., Chin, S. M., and Linn, S. 1988. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240:640-642.
15. Kirichenko, A., Li, L., Morandi, M. T., and Holian, A. 1996. 4-Hydroxy-2-nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure. Toxicol. Appl. Pharmacol. 141: 1-9.
16. Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo, W. J., Becker, S., House, D. E., McDonnell, W. F., and Bromberg, P. A. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139:407-415.
17. Lee, J. G., Madden I. C., Hatch, G. E., Bottei, G., Reed, W., Adler, K. B., and Devlin, R. B. 1995. Ozone exposure in vivo induces increases in DNA single strand breaks in human and guinea pig lung cells. Am. J. Respir. Crit. Care Med. 151:A498.
18. Lee, J. G., Madden, M. C., Reed, W., Adler, K., and Devlin, R. 1996. The use of the single cell electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro. Toxicol. Appl. Pharmacol. 141:195-204.
19. McDonald, R. J., Pan, L. C., St. George, J. A., Hyde, D. M., and Ducore, J. M 1993. Hydrogen peroxide induces DNA single strand breaks in respiratory cells. Inflammation 17:715-722.
20. McKelvey, V. J., Green. M. H. L., Schmezer, P., Pool-Zobel, B. L., DeMec, M. P., and Collins, A. 1993. The single cell gel electrophoresis assay (comet assay): A European review. Mutat. Res. 288: 47-63.
21. Mustafa, M. G. 1990. Biochemical basis of ozone toxicity. Free Radical Biol. Med. 14:245-265.
22. Nelson, W. G., and Kastan, M. B. 1994. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage responsive pathways. Mol. Cell. Biol. 4:1815-1823.
23. Olive, P. L., Banath, J. P., and Durand, R. E. 1990. Heterogeneity in radiation-induced DNA damage and repair in tumour and normal cells measured using the "comet" assay. Radiat. Res. 122:86-94.
24. Olive, P. L., Wlodek, D., Durand, R. E., and Banath, J. P. 1992. Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp. Cell Res. 198:259-260.
25. Ostling, O., and Johanson, K. J. 1984. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 123:291-298.
26. Rosner, B. 1994. Nonparametric methods. In Fundamentals of biostatistics, 4th ed., pp. 562-566. New York: Duxbury Press.
27. Sigma Chemical Company. 1996. Use of trypan blue stain and the hemocytometer to determine total cell counts and viable cell number. In Sigma Chemical Company's Biochemicals, organic compounds, and diagnostic reagents catalog, pp. 1702-1703. St. Louis, MO: Sigma Chemical Company.
28. Sina, J. F., Bean, C. L., Dysart, G. R., Taylor, V. I., and Bradley, M. O. 1983. Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutat. Res. 113:357-391.
29. Singh, N. P., McCoy, M. T., Tice, R. R., and Schneider, E. L. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:184-191.
30. Spektor, D. M., Lippman, M., Lioy, P. J., Thurston, D. G., Citak, K., James, D. J., Bock, N., Speizer, F. E., and Hayes, C. 1988a. Effects of ambient ozone on respiratory function in active, normal children. Am. Rev. Respir. Dis. 137:313-320.
31. Spektor, D. M., Lippman, M., Thurston, D. G., Lioy, P. J., Steck, J., O'Connor, G., Garshick, E., Speizer, F. E., and Hayes, C. 1988b. Effects of ambient ozone on respiratory function in healthy adults exercising outdoors. Am. Rev. Respir. Dis. 138:821-828.
32. U.S. Environmental Protection Agency. 1993. Air quality criteria for ozone and related photochemical oxidants, vol. I. EPA/600/AP-93/004a. Research Triangle Park, NC: U.S. EPA.
33. Valverde, M., del Carmen Lopez, M. Lopez, I., Sanchez, I., Fortoul, T. I., Ostrosky-Wegman, P., and Rojas, E. 1997. DNA damage in leukocytes and buccal and nasal epithelial cells of individuals exposed to air pollution in Mexico. Environ. Mol. Mutagen. 30:147-152.
34. Victorin, K. 1992. Review of the genotoxicity of ozone. Mutat. Res. 277:221-238.