메뉴 건너뛰기




Volumn 22, Issue 1, 1999, Pages 54-66

Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with theratope STn-KLH cancer vaccine

Author keywords

Carbohydrate antigen; Cellular immune response; Immunotherapy; Sialyl Tn; Stem cell rescue

Indexed keywords

CANCER VACCINE; CARBOHYDRATE ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; KEYHOLE LIMPET HEMOCYANIN; MUCIN LIKE CARCINOMA ASSOCIATED ANTIGEN; SIALIC ACID DERIVATIVE; THERATOPE STN KLH CANCER VACCINE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 0032943932     PISSN: 10538550     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-199901000-00008     Document Type: Article
Times cited : (115)

References (44)
  • 1
    • 0028131274 scopus 로고
    • Walden p. Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes. Comparison of the costimulating support provided by helper T cells and lipoamino acid
    • Borges E, Wiesmuller K-H, Jung G. Walden P. Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes. Comparison of the costimulating support provided by helper T cells and lipoamino acid. J Immunol Methods 1994;173:253-63.
    • (1994) J Immunol Methods , vol.173 , pp. 253-263
    • Borges, E.1    Wiesmuller, K.-H.2    Jung, G.3
  • 2
    • 0030996710 scopus 로고    scopus 로고
    • Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A
    • Cormier JN, Salgaller ML, Prevette T, et al. Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A. Cancer J Sci Am 1997;3:37-44.
    • (1997) Cancer J Sci Am , vol.3 , pp. 37-44
    • Cormier, J.N.1    Salgaller, M.L.2    Prevette, T.3
  • 3
    • 0026650448 scopus 로고
    • Antitumor activity and immune responses induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine
    • Kantor J, Irvine K, Abrams S, Kaufman H, DiPietro J, Schlom J. Antitumor activity and immune responses induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine. J Natl Cancer Inst 1992;84:1084-91.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1084-1091
    • Kantor, J.1    Irvine, K.2    Abrams, S.3    Kaufman, H.4    DiPietro, J.5    Schlom, J.6
  • 4
    • 0029042336 scopus 로고
    • Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine
    • Tsang KY, Zaremba S, Nieroda CA, Zhu MZ, Hamilton JM, Schlom J. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J Natl Cancer Inst 1995; 87:982-90.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 982-990
    • Tsang, K.Y.1    Zaremba, S.2    Nieroda, C.A.3    Zhu, M.Z.4    Hamilton, J.M.5    Schlom, J.6
  • 5
    • 0028205790 scopus 로고
    • Improved survival in stage III melanoma patients with GM2 antibodies: A randomized trial of adjuvant vaccination with GM2 ganglioside
    • Livingston PO, Wong GYC, Adluri S, et al. Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994;12:1036-44.
    • (1994) J Clin Oncol , vol.12 , pp. 1036-1044
    • Livingston, P.O.1    Wong, G.Y.C.2    Adluri, S.3
  • 6
    • 0027478209 scopus 로고
    • Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus detox adjuvant
    • MacLean GD, Reddish MA, Koganty RR, et al. Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant. Cancer Immunol Immunother 1993;36:215-22.
    • (1993) Cancer Immunol Immunother , vol.36 , pp. 215-222
    • MacLean, G.D.1    Reddish, M.A.2    Koganty, R.R.3
  • 7
    • 0027275052 scopus 로고
    • Immune responses of mice and human breast cancer patients following immunization with synthetic sialyl-Tn conjugated to KLH plus DETOX adjuvant
    • Longenecker BM, Reddish M, Koganty R, MacLean GD. Immune responses of mice and human breast cancer patients following immunization with synthetic sialyl-Tn conjugated to KLH plus DETOX adjuvant. Ann NY Acad Sci 1993;690:276-91.
    • (1993) Ann NY Acad Sci , vol.690 , pp. 276-291
    • Longenecker, B.M.1    Reddish, M.2    Koganty, R.3    MacLean, G.D.4
  • 8
    • 0029873154 scopus 로고    scopus 로고
    • Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine
    • MacLean GD, Reddish MA, Longenecker BM. Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine. J Immunother 1996;19: 59-68.
    • (1996) J Immunother , vol.19 , pp. 59-68
    • MacLean, G.D.1    Reddish, M.A.2    Longenecker, B.M.3
  • 9
    • 0029787977 scopus 로고    scopus 로고
    • Enhancing the effect of Theratope STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low dose intravenous cyclophosphamide
    • MacLean GD, Miles DW, Rubens RD, Reddish MA, Longenecker BM. Enhancing the effect of Theratope STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low dose intravenous cyclophosphamide. J Immunother 1996;19:309-16.
    • (1996) J Immunother , vol.19 , pp. 309-316
    • MacLean, G.D.1    Miles, D.W.2    Rubens, R.D.3    Reddish, M.A.4    Longenecker, B.M.5
  • 10
    • 0022457641 scopus 로고
    • Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3
    • Thor A, Ohuchi N, Szpak CA, Johnston WW, Schlom J. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res 1986;46:3118-24.
    • (1986) Cancer Res , vol.46 , pp. 3118-3124
    • Thor, A.1    Ohuchi, N.2    Szpak, C.A.3    Johnston, W.W.4    Schlom, J.5
  • 11
    • 0030857022 scopus 로고    scopus 로고
    • Specificities of anti-sialyl-Tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes
    • Reddish MA, Jackson L, Koganty RR, Qiu D, Hong W, Longenecker BM. Specificities of anti-sialyl-Tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes. Glycoconjugate J 1997;14:549-60.
    • (1997) Glycoconjugate J , vol.14 , pp. 549-560
    • Reddish, M.A.1    Jackson, L.2    Koganty, R.R.3    Qiu, D.4    Hong, W.5    Longenecker, B.M.6
  • 12
    • 0028901083 scopus 로고
    • Alterations in gastric mucin with malignant transformation: Novel pathway for mucin synthesis
    • Yamasha Y, Chung YS, Horie R, Kaonagi R, Sowa M. Alterations in gastric mucin with malignant transformation: novel pathway for mucin synthesis. J Natl Cancer Inst 1995;87:441-6.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 441-446
    • Yamasha, Y.1    Chung, Y.S.2    Horie, R.3    Kaonagi, R.4    Sowa, M.5
  • 13
    • 0025048023 scopus 로고
    • Sialosyl-Tn: A novel mucin antigen associated with prognosis in colorectal cancer patients
    • Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori S-I, Kim YS. Sialosyl-Tn: a novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer 1990;66:1960-6.
    • (1990) Cancer , vol.66 , pp. 1960-1966
    • Itzkowitz, S.H.1    Bloom, E.J.2    Kokal, W.A.3    Modin, G.4    Hakomori, S.-I.5    Kim, Y.S.6
  • 14
    • 0026531757 scopus 로고
    • Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer
    • Kobayashi H, Terao T, Kawashima Y. Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer. J Clin Oncol 1992;10:95-101.
    • (1992) J Clin Oncol , vol.10 , pp. 95-101
    • Kobayashi, H.1    Terao, T.2    Kawashima, Y.3
  • 16
    • 0027768747 scopus 로고
    • Synthetic tumor-associated sialyl-Tn antigen as an immunotherapeutic cancer vaccine
    • Longenecker BM, Reddish M, Miles D, MacLean GD. Synthetic tumor-associated sialyl-Tn antigen as an immunotherapeutic cancer vaccine. Vaccine Res 1993;2:151-62.
    • (1993) Vaccine Res , vol.2 , pp. 151-162
    • Longenecker, B.M.1    Reddish, M.2    Miles, D.3    Maclean, G.D.4
  • 17
    • 0025728909 scopus 로고
    • Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-Ha)
    • Fung PS, Longenecker BM. Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-Ha). Cancer Res 1991;51: 1170-6.
    • (1991) Cancer Res , vol.51 , pp. 1170-1176
    • Fung, P.S.1    Longenecker, B.M.2
  • 19
    • 0031914321 scopus 로고    scopus 로고
    • Cancer associated MUC-1 mucin inhibits human T-cell proliferation which is reversible by IL-2
    • Agrawal B, Krantz, MJ, Reddish MA, Longenecker BM. Cancer associated MUC-1 mucin inhibits human T-cell proliferation which is reversible by IL-2. Nature Med 1998;4:43-9.
    • (1998) Nature Med , vol.4 , pp. 43-49
    • Agrawal, B.1    Krantz, M.J.2    Reddish, M.A.3    Longenecker, B.M.4
  • 20
    • 0027768747 scopus 로고
    • Synthetic tumor-associated sialyl-Tn antigen as an immunotherapeutic cancer vaccine
    • Longenecker BM, Reddish M, Miles D, MacLean GD. Synthetic tumor-associated sialyl-Tn antigen as an immunotherapeutic cancer vaccine. Vaccine Res 1993;2:151-62.
    • (1993) Vaccine Res , vol.2 , pp. 151-162
    • Longenecker, B.M.1    Reddish, M.2    Miles, D.3    MacLean, G.D.4
  • 21
    • 0029017886 scopus 로고
    • + activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: Correlations with survival following active specific immunotherapy
    • + activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: correlations with survival following active specific immunotherapy. Int J Cancer 1995;61:470-4.
    • (1995) Int J Cancer , vol.61 , pp. 470-474
    • Bowen-Yacyshyn, M.1    Poppema, S.2    Berg, A.3
  • 22
    • 0029804156 scopus 로고    scopus 로고
    • A randomised phase II study of sialyl-Tn and DETOX-B™ adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer
    • Miles DW, Towlson KE, Graham R, et al. A randomised phase II study of sialyl-Tn and DETOX-B™ adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer. Br J Cancer 1996;74:1292-6.
    • (1996) Br J Cancer , vol.74 , pp. 1292-1296
    • Miles, D.W.1    Towlson, K.E.2    Graham, R.3
  • 23
    • 0023489992 scopus 로고
    • T-cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: Stimulation of anticancer T-cell immunity in vivo
    • Henningsson C, Selvaraj S, MacLean GD, Suresh MR, Noujaim AA, Longenecker BM. T-cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: stimulation of anticancer T-cell immunity in vivo. Cancer Immunol Immunother 1987;25:231-41.
    • (1987) Cancer Immunol Immunother , vol.25 , pp. 231-241
    • Henningsson, C.1    Selvaraj, S.2    MacLean, G.D.3    Suresh, M.R.4    Noujaim, A.A.5    Longenecker, B.M.6
  • 24
    • 0025777493 scopus 로고
    • Induction of α-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice
    • Singhal A. Fohn M, Hakomori S-I. Induction of α-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice. Cancer Res 1991;51:1406-11.
    • (1991) Cancer Res , vol.51 , pp. 1406-1411
    • Singhal, A.1    Fohn, M.2    Hakomori, S.-I.3
  • 26
    • 0028318850 scopus 로고
    • Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes
    • Haurum JS, Arsequell G, Lellouch AC, et al. Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J Exp Med 1994; 180:739-44.
    • (1994) J Exp Med , vol.180 , pp. 739-744
    • Haurum, J.S.1    Arsequell, G.2    Lellouch, A.C.3
  • 29
    • 3042937932 scopus 로고    scopus 로고
    • T cell recognition of Tn-glycosylated peptide antigens
    • Jensen T, Galli-Stampino L, Mouritsen S, et al. T cell recognition of Tn-glycosylated peptide antigens. Eur J Immunol 1996;26: 1342-9.
    • (1996) Eur J Immunol , vol.26 , pp. 1342-1349
    • Jensen, T.1    Galli-Stampino, L.2    Mouritsen, S.3
  • 30
    • 0030854842 scopus 로고    scopus 로고
    • T-cell recognition of tumor-associated carbohydrates: The nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity
    • Galli-Stampino L, Meinjohanns E, Frische K, et al. T-cell recognition of tumor-associated carbohydrates: the nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity. Cancer Res 1997;57:3214-22.
    • (1997) Cancer Res , vol.57 , pp. 3214-3222
    • Galli-Stampino, L.1    Meinjohanns, E.2    Frische, K.3
  • 31
    • 0021141716 scopus 로고
    • T and Tn, general carcinoma autoantigens
    • Springer GF. T and Tn, general carcinoma autoantigens. Science 1984;224:1198-206.
    • (1984) Science , vol.224 , pp. 1198-1206
    • Springer, G.F.1
  • 33
    • 0003142272 scopus 로고
    • Epitope mapping of MAb b27.29 within the peptide core of the malignant breast carcinoma-associated mucin antigen coded for the human MUC1 gene
    • Reddish M, Black N, Almeida A, Suresh MR, Longenecker BM. Epitope mapping of MAb B27.29 within the peptide core of the malignant breast carcinoma-associated mucin antigen coded for the human MUC1 gene. J Tumor Marker Oncol 1992;7:19-27.
    • (1992) J Tumor Marker Oncol , vol.7 , pp. 19-27
    • Reddish, M.1    Black, N.2    Almeida, A.3    Suresh, M.R.4    Longenecker, B.M.5
  • 34
    • 0030965064 scopus 로고    scopus 로고
    • Use of TRUQUANT BR RIA for the early detection of breast cancer recurrence in patients with stage II and stage III disease
    • Chan DW, Beveridge RA, Muss H, et al. Use of TRUQUANT BR RIA for the early detection of breast cancer recurrence in patients with stage II and stage III disease. J Clin Oncol 1997;15:2322-8.
    • (1997) J Clin Oncol , vol.15 , pp. 2322-2328
    • Chan, D.W.1    Beveridge, R.A.2    Muss, H.3
  • 35
    • 0025886470 scopus 로고
    • Clinical evaluation of a new two-site assay for CA125 antigen
    • Capstick V, MacLean GD, Suresh MR, et al. Clinical evaluation of a new two-site assay for CA125 antigen. Int J Biol Markers 1991; 6:129-35.
    • (1991) Int J Biol Markers , vol.6 , pp. 129-135
    • Capstick, V.1    MacLean, G.D.2    Suresh, M.R.3
  • 36
    • 0030239830 scopus 로고    scopus 로고
    • In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors
    • Agrawal B, Reddish MA, Longenecker BM. In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors. J Immunol 1996;157:2089-95.
    • (1996) J Immunol , vol.157 , pp. 2089-2095
    • Agrawal, B.1    Reddish, M.A.2    Longenecker, B.M.3
  • 37
    • 0004116840 scopus 로고
    • Berkeley, CA: Abacus Concepts
    • Abacus Concepts. Survival tools for STATVIEW. Berkeley, CA: Abacus Concepts, 1994.
    • (1994) Survival Tools for STATVIEW
  • 38
    • 0026693788 scopus 로고
    • Immunogenicity of Haemophilus influenzae type b conjugate vaccine in allogeneic bone marrow recipients
    • Barra A, Cordonnier C, Preziosi MP, et al. Immunogenicity of Haemophilus influenzae type b conjugate vaccine in allogeneic bone marrow recipients. J Infect Dis 1992;166:1021-8.
    • (1992) J Infect Dis , vol.166 , pp. 1021-1028
    • Barra, A.1    Cordonnier, C.2    Preziosi, M.P.3
  • 39
    • 0021338386 scopus 로고
    • Recovery of in vivo cellular immunity after human marrow grafting
    • Witherspoon RP, Matthews D, Storb R, et al. Recovery of in vivo cellular immunity after human marrow grafting. Transplantation 1984;37:145-50.
    • (1984) Transplantation , vol.37 , pp. 145-150
    • Witherspoon, R.P.1    Matthews, D.2    Storb, R.3
  • 40
    • 0025347511 scopus 로고
    • Reconstitution of the haematopoietic and immune systems after marrow transplantation
    • Atkinson K. Reconstitution of the haematopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 1990;5:209-26.
    • (1990) Bone Marrow Transplant , vol.5 , pp. 209-226
    • Atkinson, K.1
  • 41
    • 0029152203 scopus 로고
    • Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen
    • Zhang S, Walberg LA, Ogata S, et al. Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen. Cancer Res 1995;55:3364-8.
    • (1995) Cancer Res , vol.55 , pp. 3364-3368
    • Zhang, S.1    Walberg, L.A.2    Ogata, S.3
  • 42
    • 0021702359 scopus 로고
    • Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumour marker
    • Canney PA, Moore M, Wilkinson PM, James RD. Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. Br J Cancer 1984;50:765-9.
    • (1984) Br J Cancer , vol.50 , pp. 765-769
    • Canney, P.A.1    Moore, M.2    Wilkinson, P.M.3    James, R.D.4
  • 43
    • 0026596442 scopus 로고
    • Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinant using a synthetic carbohydrate antigen
    • MacLean GD, Bowen-Yacyshyn MB, Samuel J, et al. Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinant using a synthetic carbohydrate antigen. J Immunother 1992;11:292-305.
    • (1992) J Immunother , vol.11 , pp. 292-305
    • MacLean, G.D.1    Bowen-Yacyshyn, M.B.2    Samuel, J.3
  • 44
    • 0025288291 scopus 로고
    • Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate
    • Fung, PYS, Madej M, Koganty R, Longenecker BM. Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate. Cancer Res 1990;50: 4308-15.
    • (1990) Cancer Res , vol.50 , pp. 4308-4315
    • Fung, P.Y.S.1    Madej, M.2    Koganty, R.3    Longenecker, B.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.