A comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo in suppressing the cutaneous response to histamine

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 339-340

  Grant, J Andrew ^a   Danielson, Linda ^b   Rihoux, Jean Pierre ^b   DeVos, Christine ^b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UCB PHARMA   (Belgium)

Author keywords

Cetirizine; Ebastine; Epinastine; Fexofenadine; Histamine; Histamine H1 antagonists; Loratadine; Skin tests; Terfenadine

Indexed keywords

CETIRIZINE; EBASTINE; EPINASTINE; FEXOFENADINE; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; LORATADINE; TERFENADINE;

ALLERGIC REACTION; CARDIOTOXICITY; CLINICAL TRIAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; URTICARIA;

EID: 0032942763     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024126     Document Type: Conference Paper

References (3)

1. Simons FE, McMillan JL, Simons KJ: A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunol 1990;86: 540-547.
2. Juhlin L: A comparison of the pharmacodynamics of H1-receptor antagonists as assessed by the induced wheal- and-flare model. Allergy 1995;50:24-30.
3. Monroe EW, Daly AF, Shalhoub RF: Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines. J Allergy Clin Immunol 1997;99:S798-806.