Perspective: Chromosomal translocations can affect genes controlling gene expression and differentiation - Why are these functions targeted?

Journal of Pathology

Volumn 187, Issue 1, 1999, Pages 39-42

  Rabbitts, T H ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Cancer; Chromosomal translocation; Development; Differentiation; Leukaemia; Oncogenes

Indexed keywords

GENE PRODUCT; HYBRID PROTEIN; TRANSCRIPTION FACTOR;

CANCER; CHROMOSOME TRANSLOCATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; LEUKEMIA; ONCOGENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NEOPLASMS; ONCOGENES; TRANSLOCATION, GENETIC;

EID: 0032940949     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199901)187:1<39::AID-PATH235>3.0.CO;2-Q     Document Type: Review

References (41)

1. Rabbins TH. Chromosomal translocations in human cancer. Nature 1994; 372: 143-149.
2. Rabbitts TH, Hamlyn PH, Baer R. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 1983; 306: 760-765.
3. Rabbitts TH, Forster A, Hamlyn PH, Baer R. Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma. Nature 1984; 309: 592-597.
4. Showe LC, Ballantine M, Nishikura K, Erikson J, Kaji H, Croce CM. Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region. Mol Cell Biol 1985; 5: 501-509.
5. Murphy W, Sarid J, Taub R, et al. Translocated human c-myc oncogene is altered in a conserved coding sequence. Proc Natl Acad Sci USA 1986; 83: 2939-2943.
6. Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nature Genet 1993; 5: 56-61.
7. Cleary ML. Oncogenic conversion of transcription factors by chromosomal translocations. Cell 1991; 66: 619-622.
8. Rabbitts TH. Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell 1991; 67: 641-644.
9. Look AT. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278: 1059-1065.
10. Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993; 363: 640-644.
11. Rabbitts TH, Forster A, Larson R, Nathan P. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nature Genet 1993; 4: 175-180.
12. Ron D, Habener JF, CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-453.
13. Sanchez-Garcia I, Rabbitts TH. Transcriptional activation by TAL1 and FUS CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities. Proc Natl Acad Sci USA 1994; 91: 7869-7873.
14. Hockenberry DM, Oitval ZN, Yin X-M, Milliman CL. Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-251.
15. Kane DJ, Sarafian TA, Anton R, et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species Science 1993; 262: 1274-1277.
16. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 1993; 4: 327-332.
17. Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH. Rabbitts TH. The oncogenic cysteine-nch LIM domain protein rbtn2 is essential for erythroid development. Cell 1994; 78: 45-58.
18. Robb L, Lyons I, Li R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci USA 1995; 92: 7075-7079.
19. Shivdasani RA, Mayer E, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 1995; 373: 432-434.
20. Yu BD, Hess JL, Horning SE, Brown GAJ, Korsmeyer SJ. Altered Hox expression and segmental identity in M//-mutant mice. Nature 1995; 378: 505-508.
21. Porcher C, Swat W, Rockwell K, Fujuwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SC1/tal-1 is essential for development of all hematopoietic lineages. Cell 1996; 86: 47-57.
22. Robb L, Elwood NJ, Elefanty AG, et al. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J 1996; 15: 4123-4129.
23. Yamada Y, Warren AW, Dobson C, Forster A, Pannell R, Rabbitts TH. The T cell leukaemia LIM protein Lmo2 is necessary for adult mouse haematopoiesis. Proc Natl Acad Sci USA 1998; 95: 3890-3895.
24. Dear TN, Colledge WH, Carlton MBL, et al. The Hox11 gene is essential for cell survival during spleen development. Development 1995; 121: 2909-2915.
25. Roberts CW, Sonder AM, Lumsden A, Korsmeyer SJ. Developmental expression of Hox11 and specification of splenic cell fate. Am J Pathol 1995; 146: 1089-1101.
26. Harris H. The role of differentiation in the suppression of malignancy. J Cell Sci 1990; 97: 5-10.
27. Larson RC, Obada H, Larson TA, Lavenir I, Rabbitts TH. The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice. Ontogene 1995; 11: 853-862.
28. Foroni L, Boehm T, White L, et al. The rhombotin gene family encode related LIM-domam proteins whose differing expression suggests multiple roles in mouse development. J Mol Biol 1992; 226: 747-761.
29. Adams JM, Cory S. Transgenic models of tumour development. Science 1991; 254: 1161-1167.
30. Rabbitts TH (ed.). Seminars in Cancer Biology: Chromosomal Abnormalities and Leukaemia. Vol. 4, New York: Academic Press, 1993.
31. Valge-Archer VE, Osada H, Warren AJ, et al. The LIM protein RBTN2 and the bHLH protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci USA 1994; 91: 8617-8621.
32. Wadman I, Li J, Bash RO, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukaemia. EMBO J 1994; 13: 4831-4839.
33. Larson RC, Lavenir I, Larson TA, et al. Protein dimerisation between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J 1996; 15: 1021-1027.
34. Der CJ, Krontiris T, Cooper G. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci USA 1982; 79: 3637-3640.
35. Parada LF, Tabin CJ, Shih C, Weinberg RA, Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 1982; 297: 474-478.
36. Santos E, Tronick S, Aaronson SA, Pulciani S, Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal humans homologue of BALB-and Harvey-MSV transforming genes. Nature 1982; 298: 343-347.
37. Goldfarb M, Shimizu K, Perucho M, Wigler M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 1982; 296: 404-409.
38. Boehm T, Foroni L, Kaneko Y, Perutz MP, Rabbitts TH. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci USA 1991; 88: 4367-4371.
39. Royer-Pokora B, Loos U, Ludwig W-D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 1991; 6: 1887-1893.
40. Rabbitts TH. LMO T cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Genes Dev 1998; 12: 2651-2657.
41. Rabbitts TH, Bucher K, Chung G, Grütz GG, Warren AJ, Yamada Y. The effect of chromosomal translocations in acute leukaemias: the LMO2 paradigm in transcription and development. Cancer Res (in press).