Two cases of pituitary Crooke's cell adenoma without Cushing's disease: A histologic, immunocytochemical, electron microscopic and in situ hybridization study

Endocrine Pathology

Volumn 10, Issue 1, 1999, Pages 65-72

  Kovacs, Kalman ^a   Horvath, Eva ^a   Stefaneanu, Lucia ^a   Bilbao, Juan M ^a   Singer, William ^a   Muller, Paul ^a   Scheithauer, Bernd W ^b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b MAYO CLINIC   (United States)

Author keywords

ACTH; Cushing's disease; Microfilaments; Pituitary; Pituitary adenoma

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; PROOPIOMELANOCORTIN;

ADULT; ARTICLE; CASE REPORT; CROOKE CELL ADENOMA; CUSHING DISEASE; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION; HISTOLOGY; HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICROFILAMENT; PRIORITY JOURNAL;

EID: 0032939781     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02738817     Document Type: Article

References (30)

1. Felix IA, Horvath E, Kovacs K. Massive Crooke's hyalinization in corticotroph cell adenoma of the human pituitary. A histological, immunocytochemical, and electron microscopic study of three cases. Acta Neurochir 58:235-243, 1981.
2. Horvath E, Kovacs K, Josse R. Pituitary corticotroph cell adenoma with marked abundance of microfilaments. Ultrastruct Pathol 5:249-255, 1983.
3. Horvath E, Kovacs K. The adenohypophysis. In: Kovacs K, Asa SL, eds. Functional Endocrine Pathology, 2nd ed. Boston: Blackwell, 1998;247-281.
4. Horvath E, Kovacs K. Ultrastructural diagnosis of human pituitary adenomas. Micr Res Techn 20:107-135, 1992.
5. Kovacs K, Scheithauer BW, Horvath E, Lloyd RV. The World Health Organization classification of adenohypophysial neoplasms. A proposed five-tier scheme. Cancer 78:502-510, 1996.
6. Kovacs K. The pathology of Cushing's disease. J Steroid Biochem Mol Biol 45:179-182, 1993.
7. Horvath E, Scheithauer BW, Kovacs K, Lloyd RV. Regional neuropathology: hypothalamus and pituitary. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology, 6th ed. London: Arnold, 1997; 1007-1094.
8. Crooke AC. A change in the basophil cells of the pituitary gland common to conditions which exhibit the syndrome attributed to basophil adenoma. J Pathol Bacteriol 41:339-349, 1935.
9. Neuman PE, Horoupian DS, Goldman JE, Hess MA. Cytoplasmic filaments of Crooke's hyaline change belong to the cytokeratin class. An immunocytochemical and ultrastructural study. Am J Pathol 116:214-222, 1984.
10. Kovacs K, Horvath E. Tumors of the pituitary gland. Atlas of Tumor Pathology, 2nd series, Armed Forces Institute of Pathology, Bethesda: fascicle 21. 1986.
11. Kovacs K, Stefaneanu L, Ezzat S, Smyth HS. Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. Arch Pathol Lab Med 118:562-565, 1994.
12. Kovacs K, Giannini C, Scheithauer BW, Stefaneanu L, Lloyd RV, Horvath E. Pituitary changes in ataxia-telangiectasia syndrome: an immunocytochemical, in situ hybridization, and DNA cytometric study of three cases. Endocr Pathol 8:195-203, 1997.
13. Kovacs K, Lloyd RV, Horvath E, Asa SL, Stefaneanu L, Killinger DW. Silent somatotroph adenomas of the human pituitary. A morphologic study of three cases including immunocytochemistry, electron microscopy, in vitro examination, and in situ hybridization. Am J Pathol 134:345-353, 1989.
14. Kovacs K, Stefaneanu L, Horvath E, Lloyd RV, Lancranjan I, Buchfelder M, et al. Effect of dopamine agonist medication on prolactin producing pituitary adenomas. A morphological study including immunocytochemistry, electron microscopy and in situ hybridization. Virchows Arch Pathol Anat 418:439-446, 1991.
15. Stefaneanu L, Kovacs K, Horvath E, Lloyd RV. In situ hybridization study of proopiomelanocortin (POMC) gene expression in human pituitary corticotrophs and their adenomas. Virchows Arch Pathol Anat 419:107-113, 1991.
16. Kovacs K, Stefaneanu L, Horvath E, Buchfelder M, Fahlbusch R, Becker W. Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. J Neurosurg 82:886-890, 1995.
17. Orth DN. Cushing's Syndrome. N Engl J Med 332:791-803, 1995.
18. Dickstein G, Spindel A, Shechner C, Adawi F, Gutman H. Spontaneous remission in Cushing's disease. Arch Intern Med 151:185-189, 1991.
19. Ishibashi M, Shimada K, Abe K, Furue H, Yamaji T. Spontaneous remission in Cushing's disease. Arch Intern Med 153:251-255, 1993.
20. Dickstein G, Arad E, Shechner C. Late complications in remission from Cushing disease. Recurrence of tumor with reinfarction or transformation into a silent adenoma. Arch Intern Med 157:2377-2380, 1997.
21. Bamberger CM, Schulte HM, Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17:245-261, 1996.
22. Clark AJL. Receptor hypersensitivity: a new phenomenon? Clin Endocrin 48:135-136, 1998.
23. Horvath E, Kovacs K, Killinger DW, Smyth HS, Platts ME, Singer W. Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic and ultrastructural study. Am J Pathol 98:617-638, 1980.
24. Horvath E, Kovacs K, Lloyd RV. Pars intermedia of the human pituitary revisited: morphologic aspects and frequency of hyperplasia of POMC-peptide immunoreactive cell. Endocrin Pathol (in press).
25. Kovacs K, Horvath E, Stratmann I, Ezrin C. Cytoplasmic microfilaments in the anterior lobe of the human pituitary gland. Acta Anat 87:414-426, 1974.
26. Robert F, Pelletier G, Hardy J. Pituitary adenomas in Cushing's disease. A histologic, ultrastructural and immunocytochemical study. Arch Pathol Lab Med 102:448-455, 1978.
27. Burgess TL, Kelly RB. Constitutive and regulated secretion of proteins. Ann Rev Cell Biol 3:243-293, 1987.
28. Aunis D, Bader MF. The cytoskeleton as a barrier to exocytosis in secretory cells. J Exp Biol 139:253-266, 1988.
29. Ravindra R, Grosvenor CE. Involvement of cytoskeleton in polypeptide hormone secretion from the anterior pituitary lobe: a review. Mol Cell Endocrinol 71:165-176, 1990.
30. Castellino F, Heuser J Heuserj, Marchetti S, Bruno B, Luini A. Glucocorticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotropin release. Proc Natl Acad Sci USA 89:3775-3779, 1992.