Pituitary Changes in Ataxia-Telangiectasia Syndrome: An Immunocytochemical, In Situ Hybridization, and DNA Cytometric Study of Three Cases

Endocrine Pathology

Volumn 8, Issue 3, 1997, Pages 195-203

  Kovacs, Kalman ^a   Giannini, Caterina ^b   Scheithauer, Bernd W ^b   Stefaneanu, Lucia ^a   Lloyd, Ricardo V ^b   Horvath, Eva ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b MAYO CLINIC   (United States)

Author keywords

Ataxia telangiectasia; DNA ploidy; Immunocytochemistry; In situ hybridization; Pituitary

Indexed keywords

EID: 0000395430     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02738786     Document Type: Article

References (40)

1. Swift M, Morrell D, Cromartie E, Chamberlin AR, Skolnick MH, Bishop DT. The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39:573-583, 1986.
2. Gatti RA. Ataxia-telangiectasia. Dermatol Clin 13:1-6, 1995.
3. Swift A, Morrell D, Massey RB, Chase CL. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325:1831-1836, 1991.
4. Syllaba L, Henner K. Contribution à l'independance de l'athétose double idiopathique et congenitale. Rev Neurol 1:541-562, 1926.
5. Louis-Bar D. Sur un syndrome progressif comprenant des télangiectasies capillaires cutanées et conjonctivales symétriques, à disposition naevoide et de troubles cérébelleux. Confin Neurol (Baser) 4:32-42, 1941.
6. Aguilar MJ, Kamoshita S, Landing BH, Boder E, Sedgwick RP. Pathological observations in ataxia-telangiectasia. A report of five cases. J Neuropath Exp Neurol 27:659-676, 1968.
7. Boder E, Sedgwick RP. Ataxia-telangiectasia: a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. Pediatrics 21:526-554, 1958.
8. Boder E. Ataxia-telangiectasia: some historic, clinical and pathologic observations. Birth Defects 11:255-270, 1975.
9. Gatti RA. Speculations on the ataxia-telangiectasia defect. Clin Immunol Immunopathol 61:S10-S15, 1991.
10. Gatti RA, Boder E, Vinters HV, Sparkes RS, Norman A, Lange K. Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis. Medicine 70:99-117, 1991.
11. Kobayashi Y, Tycko B, Soreng AL, Sklar J. Transrearrangements between antigen receptor genes in normal human lymphoid tissues and in ataxia telangiectasia. J Immunol 147:3201-3209, 1991.
12. Taylor AMR. Ataxia telangiectasia genes and predisposition to leukaemia, lymphoma and breast cancer. Br J Cancer 66:5-9, 1992.
13. Metcalfe JA, Parkhill J, Campbell L, Stacey M, Biggs P, Byrd PJ, Taylor AMR. Accelerated telomere shortening in ataxia telangiectasia. Nature Genet 13:350-353, 1996.
14. Llerena JC Jr, Murer-Orlando M. Bloom syndrome and ataxia telangiectasia. Semin Hematol 28:95-103, 1991.
15. Savitsky K, Bar-Shiva A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-1753, 1995.
16. Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, et al. The complete sequence of the coding region of the ATM gene reveals similarity to the cell cycle regulators in different species. Hum Mol Genet 4:2025-2032, 1995.
17. Mayn MS. Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res 55:5991-6001, 1995.
18. Zakian VA. ATM-related genes: what do they tell us about functions of the human gene? Cell 82:685-687, 1995.
19. McConville CM, Stankovic T, Byrd PJ, McGuire GM, Yao Q-J, Lennox GG, Taylor AMR. Mutations associated with variant phenotypes in ataxia-telangiectasia. Am J Hum Genet 59:320-330, 1996.
20. Telatar M, Wang Z, Udar N, Liang T, Bernatowska-Matuszkiewicz E, Lavin M, Shiloh Y, Concannon P, Good RA, Gatti RA. Ataxia-telangiectasia: mutations in ATMc-DNA detected by protein-truncation screening. Am J Hum Genet 59:40-44, 1996.
21. Kovacs K, Lloyd R, Horvath E, Asa SL, Stefaneanu L, Killinger DW, Smyth HS. Silent somatotroph adenomas of the human pituitary. A morphologic study of three cases including immunocytochemiscry, electron microscopy, in vitro examination, and in situ hybridization. Am J Pathol 134:345-353, 1989.
22. Kovacs K, Stefaneanu L, Horvath E, Lloyd RV, Lancranjan I, Buchfelder M, Fahlbusch R. Effects of dopamine agonist medication on prolactin producing pituitary adenomas: a morphologic study including immunocytochemistry, electron microscopy and in situ hybridization. Virchows Arch Pathol Anat 418:439-446, 1991.
23. Horvath E, Kovacs K, Scheithauer BW, Lloyd RV, Smyth HS. Pituitary adenoma with neuronal choristoma (PANCH): composite lesion or lineage infidelity? Ultrastruct Pathol 18:565-574, 1994.
24. Centerwall WR, Miller MM. Ataxia, telangiectasia, and sinopulmonary infections. A syndrome of slowly progressive deterioration in childhood. Am J Dis Child 95:385-396, 1958.
25. Dunn HG, Meuwissen H, Livingstone CS, Pump KK. Ataxia-telangiectasia. Canad Med Ass J 91:1106-1118, 1964.
26. McFarlin DE, Strober W, Waldmann TA. Ataxia-telangiectasia. Medicine 51:281-314, 1972.
27. Smith LL, Conerly SL. Ataxia-telangiectasia or Louis-Bar syndrome. J Am Acad Dermatol 12:681-696, 1985.
28. Woods CG, Taylor AMR. Ataxia telangiectasia in the British Isles: the clinical and laboratory features of 70 affected individuals. Q J Med 82:169-179, 1992.
29. Moghadam BKH, Zadeh JY, Gier RE. Ataxia-telangiectasia. Review of the literature and a case report. Oral Surg Oral Med Oral Pathol 75:791-797, 1993.
30. Richkind KE, Boder E, Teplitz RL. Fetal proteins in ataxia-telangiectasia. JAMA 248: 1346,1347, 1982.
31. Bowden DH, Danis PG, Sommers SC. Ataxia-telangiectasia. A case with lesions of ovaries and adenohypophysis. J Neuropath Exp Neurol 22:549-554, 1963.
32. Ammann AJ, Duquesnoy RJ, Good RA. Endocrinological studies in ataxia-telangiectasia and other immunological deficiency diseases. Clin Exp Immunol 6:587-595, 1970.
33. Zadik Z, Levin S, Prager-Lewin R, Laron Z. Gonadal dysfunction in patients with ataxia telangiectasia. Acta Paediatr Scand 67:477-479, 1978.
34. Strich SJ. Pathological findings in three cases of ataxia-telangiectasia. J Neurol Neurosurg Psychiat 29:489-499, 1966.
35. Solitare GB, Lopez VF. Louis-Bar's syndrome (ataxia-telangiectasia). Neuropathologic observations. Neurology 17:23-31, 1967.
36. Solitare GB. Louis-Bar's syndrome (ataxiatelangiectasia). Anatomic considerations with emphasis on neuropathologic observations. Neurology 18:1180-1186, 1968.
37. Scott RE. Ataxia-telangiectasia. Arch Pathol 88:78-84, 1969.
38. Thapar K, Kovacs K, Scheithauer BW, Stefaneanu L, Horvath E, Pernicone PJ, Murray D, Laws ER Jr. Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody. Neurosurgery 38:99-107, 1996.
39. Thapar K, Scheithauer BW, Kovacs K, Pernicone PJ, Laws ER Jr. p53 expression in pituitary adenomas and carcinomas: correlations with invasiveness and tumor growth fractions. Neurosurgery 38:765-771, 1996.
40. Harris C, Holstein M. Clinical implications of the p53 tumor suppressor gene. N Engl J Med 329:1318-1327, 1993.