Inhibition of the phosphorylation of a myristoylated alanine-rich C kinase substrate by methyl methanesulfonate in cultured NIH 3T3 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 351, Issue 2, 1996, Pages 163-171

  Shin, I ^a   Kam, Y ^a   Ha, K S ^a   Kang, K W ^a   Joe, C O ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Methyl methanesulfonate; Myristoylated alanine rich C kinase; Phospholipase C; Protein kinase C; Substrate

Indexed keywords

ALANINE DERIVATIVE; MARCKS PROTEIN; MESYLIC ACID METHYL ESTER; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; ENZYME INHIBITION; ENZYME SUBSTRATE; FIBROBLAST; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALIA;

EID: 0029991081     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00231-6     Document Type: Article

References (49)

1. K.A. Albert S.I. Walaas J.K. Wang P. Greengard Widespread occurrence of ‘87 kDa’, a major specific substrate for protein kinase C Proc. Natl. Acad. Sci. USA 83 1986 2822 2826
2. K.A. Albert A.C. Nairn P. Greengard The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization Proc. Natl. Acad. Sci. USA 84 1987 7046 7050
3. Y. Arita K.R. O'Driscoll I.B. Weinstein Growth of human melanocyte cultures supported by 12-O-tetradecanoylphorbol-13-acetate is mediated through protein kinase C activation Cancer Res. 52 1992 4514 4521
4. M.J. Berridge R.F. Irvine Inositol trisphosphate, a novel second messenger in cellular signal transduction Nature 312 1984 315 321
5. P.J. Blackshear L.A. Witters P.R. Girard J.F. Kuo S.N. Quamo Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways J. Biol. Chem. 260 1985 13304 13315
6. P.J. Blackshear The MARCKS family of cellular protein kinase C substrates J. Biol. Chem. 268 1993 1501 1504
7. S.F. Brooks T. Herget S. Broad E. Rozengurt The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways J. Biol. Chem. 267 1992 14212 14218
8. R. Calle S. Ganesan J.I. Smallwood H. Rasmussen Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets J. Biol. Chem. 267 1992 18723 18727
9. M.H. Cardone B.L. Smith W. Song D. Mochly-Rosen K.E. Mostov Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells J. Cell. Biol. 124 1994 717 727
10. D.A. Carpenter G.A. Sega Unscheduled DNA synthesis induced in mouse spermatids after combined treatment with methyl methanesulfonate and X-rays Mutation Res. 50 1978 219 228
11. F.J. Carr B.W. Fox The effects of bifunctional alkylating agents on DNA synthesis in sensitive and resistant Yoshida cells Mutation Res. 95 1982 441 456
12. D.D. Chaplin H.J. Wedner C.W. Parker Protein phosphorylation in human peripheral blood lymphocytes: mitogen-induced increases in protein phosphorylation in intact lymphocytes J. Immunol. 124 1980 2390 2398
13. J.M. Clarkson D.L. Mitchell The recovery of mammalian cells treated with methyl methanesulfonate, nitrogen mustard or UV light. I. The effect of alkylation products on DNA replication Mutation Res. 61 1979 333 342
14. S. Detke J.L. Stein G.S. Stein Influence of chlorambucil, a bifunctional alkylating agent, on DNA replication and histone gene expression in HeLa S3 cells Cancer Res. 40 1980 967 974
15. T. Eichholtz P. Vossebeld M. van-Overveld H. Ploegh Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status J. Biol. Chem. 267 1992 22490 22495
16. J.M. Graff T.N. Young J.D. Johnson P.J. Blackshear Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C J. Biol. Chem. 264 1989 21818 21823
17. J.M. Graff R.R. Rajan R.R. Randall A.C. Nairn P.J. Blackshear Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain J. Biol. Chem. 266 1991 14390 14398
18. A. Graham M. Fox The role of suppression of DNA synthesis and inhibition of cell cycle progression in cellular sensitivity to alkylation damage Carcinogenesis 4 1983 269 274
19. J.H. Hartwig M. Thelen A. Rosen P.A. Janmey A.C. Nairn A. Aderem MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin Nature 356 1992 618 622
20. T. Herget S.F. Brooks S. Broad E. Rozengurt Expression of the major protein kinase C substrate, the acidic 80-kilodalton myristoylated alanine-rich C kinase substrate, increases sharply when Swiss 3T3 cells move out of cycle and enter G0 Proc. Natl. Acad. Sci. USA 90 1993 2945 2949
21. H.K. Kim J.W. Kim A. Zilberstein B. Margolis J.G. Kim J. Schlessinger S.G. Rhee PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254 Cell 65 1991 435 441
22. 2+, phospholipid-dependent protein kinase associated with plasma membrane Nature 301 1983 621 623
23. P.S. Linsley M. Bolton-Hanson D. Horn N. Malik J.C. Kallestad V. Ochs J.M. Zarling M. Shoyab Identification and characterization of cellular receptors for the growth regulator, oncostatin M J. Biol. Chem. 264 1989 4282 4289
24. B. Ljunggren S.R. Cohen D.M. Carter S.I. Wayne Chlorpromazine phototoxicity: growth inhibition and DNA-interaction in normal human fibroblasts J. Invest. Dermatol. 75 1980 253 256
25. M.C. MacLeod A. Kootstra B.K. Mansfield T.J. Slaga J.K. Selkirk Specificity in interaction of benzo(a)pyrene with nuclear macromolecules: implication of derivatives of two dihydrodiols in protein binding Proc. Natl. Acad. Sci. USA 77 1980 6396 6400
26. P.W. Majerus T.M. Connolly H. Deckmyn T.S. Ross T.E. Bross H. Ishii V.S. Bansal D.B. Wilson The metabolism of phosphoinositide-derived messenger molecules Science 234 1986 1519 1526
27. S. Manenti O. Sorokine A. van Dorsselaer H. Taniguchi Affinity purification and characterization of myristoylated alanine-rich protein kinase C substrate (MARCKS) from bovine domain. Comparison of the cytoplasmic and the membrane-bound forms J. Biol. Chem. 267 1992 22310 22315
28. B.K. McIlroy J.D. Walters P.J. Blackshear J.D. Johnson Phosphoylation-dependent binding of a synthetic MARCKS peptide to calmodulin J. Biol. Chem. 266 1991 4959 4964
29. J. Meisenhelder P.G. Suh S.G. Rhee T. Hunter Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro Cell 57 1989 1109 1122
30. P.D. Moore K.K. Bose S.D. Rabkin B.S. Strauss Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated Φ × 174 templates by prokaryotic and eukaryotic DNA polymerase Proc. Natl. Acad. Sci. USA 78 1981 110 114
31. Y. Nishizuka Turnover of inositol phospholipids and signal transduction Science 225 1984 1365 1370
32. J.O. Norman C.O. Joe D.L. Busbee Inhibition of DNA polymerase activity by methyl methanesulfonate Mutation Res. 165 1986 71 79
33. P.H. O'Farrell High resolution two-dimensional electrophoresis of proteins J. Biol. Chem. 250 1975 4007 4021
34. R.B. Painter Inhibition of initiation of HeLa cell replicons by methyl methanesulfonate Mutation Res. 42 1977 299 303
35. A.R. Peterson DNA synthesis, mutagenesis, DNA damage and cytotoxicity in cultured mammalian cells treated with alkylating agents Cancer Res. 40 1980 682 688
36. J.A. Reynolds C. Tanford Binding of dodecyl sulfate to proteins at high binding ratios. Possible implications for the state of proteins in biological membranes Proc. Natl. Acad. Sci. USA 66 1970 1002 1007
37. P.J. Robinson Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes J. Biol. Chem. 267 1992 21637 21644
38. P.J. Robinson J.P. Liu W. Chen T. Wenzel Activation of protein kinase C in vitro and in intact cells or synaptosomes determined by acetic acid extraction of MARCKS Anal. Biochem. 210 1993 172 178
39. A. Rosen K.F. Keenan M. Thelen A.C. Nairn A. Aderem Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrates from punctate stuctures in macrophage filopodia J. Exp. Med. 172 1990 1211 1215
40. E. Rozengurt M. Rodriguez-Pena K.A. Smith Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells Proc. Natl. Acad. Sci. USA 80 1983 7244 7248
41. T. Sawai M. Negishi N. Nishigaki T. Ohno A. Ichikawa Enhancement by protein kinase C of prostacyclin receptor-mediated activation of adenylate cyclase through a calmodulin/myristoylated alanine-rich C kinase substrate (MARCKS) system in IC2 mast cells J. Biol. Chem. 268 1993 1995 2000
42. I. Shin Y.S. Yoon K.W. Kang S.D. Park C.O. Joe Inhibition of 80 kDa protein phosphorylation by short-wave-length UV light in NIH 3T3 cells Photochem. Photobiol. 58 1993 536 540
43. D.J. Stumpo J.M. Graff K.A. Albert P. Greengard P.J. Blackshear Molecular cloning, characterization, and expression of a cDNA encoding the ‘80- to 87-kDa’ myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C Proc. Natl. Acad. Sci. USA 86 1989 4012 4016
44. P.G. Suh S.H. Ryu W.C. Choi K.Y. Lee S.G. Rhee Monoclonal antibodies to three phospholipase C isozymes from bovine brain J. Biol. Chem. 263 1988 14497 14504
45. M.I. Wahl S. Nishibe P.G. Suh S.G. Rhee G. Carpenter Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium Proc. Natl. Acad. Sci. USA 86 1989 1568 1572
46. γ in quiescent BALB c 3T3 cells Mol. Cell Biol. 9 1989 2934 2943
47. D. Wessel U.I. Flugge A method for the quantitive recovery of protein in dilute solution in the presence of detergents and lipids Anal. Biochem. 138 1984 141 143
48. A. Wolfman T.G. Wingrove P.J. Blackshear I.G. Macara Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts J. Biol. Chem. 262 1987 16546 16552
49. W.C. Wu S.I. Walaas A.C. Nairn P. Greengard Calcium/phospholipid regulates phosphorylation of a Mr ‘87k’ substrate protein in brain synaptosomes Proc. Natl. Acad. Sci. USA 79 1982 5249 5253