Expression of interferon-γ in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic lewis rats

Clinical Immunology

Volumn 91, Issue 2, 1999, Pages 196-205

  Egwuagu, Charles E ^b   Mahdi, Rashid M ^b   Chan, Chi Chao ^b   Sztein, Jorge ^a   Li, Wenmei ^b   Smith, Janine A ^b   Chepelinsky, Ana B ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b NONE

Author keywords

Apoptosis; Interferon ; Retinal degeneration; Transgenic rat; Uveitis

Indexed keywords

GAMMA INTERFERON;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL PROTECTION; CELL SURVIVAL; DRUG EFFECT; IRIDOCYCLITIS; LENS CAPSULE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; RETINA GANGLION CELL; TRANSCRIPTION REGULATION; UVEITIS; VISUAL ACUITY;

EID: 0032938819     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1999.4701     Document Type: Article

References (52)

1. Boehm U., Klamp T., Howard J. C. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15:1997;749-795.
2. Kalvakolanu D. V., Borden E. C. An overview of the interferon system: Signal transduction and mechanisms of action. Cancer Invest. 14:1996;25-53.
3. Young H. A., Hardy K. J. Role of interferon-γ in immune cell regulation. J. Leukocyte Biol. 58:1995;373-381.
4. Nguyen H., Hiscott J., Pitha P. M. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 8:1997;293-312.
5. Muhlethaler-Mottet A., Berardino W. D., Otten L. A., Mach B. Activation of the MHC class II transactivator CIITA by interferon-γ requires cooperative interaction between Stat1 and USF-1. Immunity. 8:1998;157-166.
6. Naik S. M., Shigagaki N., Li L. J., Quinlan K. L., Paxton L. L., Caughman S. W. Interferon gamma-dependent induction of human intercellular adhesion molecule-1 gene expression involves activation of a distinct STAT protein complex. J. Biol. Chem. 272:1997;1283-1290.
7. Spink J., Evan T. Binding of the transcription factor interferon regulatory factor-1 to the inducible nitric-oxide synthase promoter. J. Biol. Chem. 272:1997;24417-24425.
8. Hassel B. A., Zhou A., Sotomayor C., Maran A., Silverman R. H. A dominant negative mutant of 2-5-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12:1993;3297-3304.
9. Sen G. C., Ransohoff R. M. Interferon-induced antiviral actions and their regulation. Adv. Virus. Res. 42:1993;57-101.
10. Ozaki Y., Edelstein M. P., Duch D. S. Induction of indoleamine 2,3-dioxygenase: A mechanism of the antitumor activity of IFN-gamma. Proc. Natl. Acad. Sci. USA. 85:1988;1242-1246.
11. Taniguchi T. Transcription factors IRF1 and IRF2: Linking the immune responses and tumor suppression. J. Cell. Phys. 173:1997;128-130.
12. Vaughan P. S., Aziz F., van Wijnen A. J., Wu S., Harada H., Taniguchi T., Soprano K. J., Stein J. L., Stein G. S. Activation of a cell cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature. 377:1995;362-365.
13. Yamamoto H., Lamphier M. S., Fujita T., Taniguchi T., Harada H. The oncogenic transcription factor IRF-2 possesses a transcriptional repression and latent activation domain. Oncogene. 9:1994;1423-1428.
14. Billiau A. Interferon-γ in autoimmunity. Cytokine Growth Factor Rev. 7:1996;25-34.
15. Tang H., Mignon-Godefrey K., Meroni P. L., Garotta G., Charriere J., Nicoletti F. The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): Prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol. 23:1993;275-278.
16. Campbell I. L., Kay T. W. H., Oxbrow L., Harrison L. C. Essential role of interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:1991;739-742.
17. Hartung H-P., Shafer B., Van der Meide P. H., Fierz W., Heininger K., Toyka K. V. The role of interferon-gamma in the pathogenesis of experimental autoimmune diseases of the periferal nervous system. Ann. Neurol. 27:1990;247-257.
18. Krakowski M., Owens T. Interferon-γ confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26:1996;1641-1646.
19. Ferber I. A., Brocke S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., Dalto D., Fathman C. G. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:1996;5-7.
20. Willenborg D. O., Fordham S., Bernard C. C. A., Cowden W. B., Ramshaw I. A. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157:1996;3223-3227.
21. Bottazzo G. F., Pujol-Borrell R., Hanafusa T., Feldmann. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet. II:1983;1115-1118.
22. Hanafusa T., Chiovato L., Doniach D., Pujol-Borrell R., Russell R. C. G., Bottazzo G. F. Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: Relevance for autoimmunity. Lancet. II:1983;1111-1115.
23. Limb G. A., Little B. C., Meager A., Ogilvie J. A., Wolstencroft R. A., Franks W. A., Chignell A. H., Dumonde D. C. Cytokines in proliferative vitreoretinopathy. Eye. 5:1991;686-693.
24. Chan C. C., Hooks J. J., Nussenblatt R. B., Detrick B. Expression of la antigen on retinal pigment epithelium in experimental autoimmune uveoretinitis. Curr. Eye Res. 5:1986;325-330.
25. Detrick B., Newsome D. A., Percopo C. M., Hooks J. J. Class II antigen expression and gamma interferon modulation of monocytes and retinal pigment epithelial cells from patients with retinitis pigmentosa. Clin. Immunol. Immunopathol. 36:1985;201-211.
26. Detrick B., Rodrigues M., Chan C. C., Tso M., Hooks J. J. Expression of HLA-DR antigen on retinal pigment epithelial cells in retinitis pigmentosa. Am. J. Ophthalmol. 101:1986;584-590.
27. Detrick B., Rodrigues M., Chan C. C., Detrick B. Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases. Invest. Ophthalmol. Vis. Sci. 29:1988;1444-1451.
28. Feldman M., Londei M., Buchan G. Interferons and Autoimmunity. Interferon. 9:1987;75-90.
29. Caspi R. R., Chan C. C., Grubbs B. G., Silver P. B., Wiggert B., Parsa C. F., Bahmanyar S., Billiau A., Heremans H. Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J. Immunol. 152:1994;890-899.
30. Kogiso M., Tanouchi Y., Mimura Y., Nagasawa H., Himeno K. Endotoxin-induced uveitis in mice. 1. Induction of uveitis and role of T lymphocytes. Japan J. Ophthalmol. 36:1992;281-290.
31. Whitcup S. M., Rizzo L. V., Lai J. C., Hayashi S., Gazzinelli R., Chan C. C. IL-12 inhibits endotoxin-induced inflammation in the eye. Eur. J. Immunol. 26:1996;995-999.
32. Panitch H. S., Haley A. S., Hirsch R. L., Johnson K. P. Exacerbations of multiple sclerosis in patients with gamma interferon. Lancet. 1:1987;893-895.
33. Panitch H. S., Hirsch R. L., Schindler J., Johnson K. P. Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system. Neurology. 37:1987;1097-1102.
34. Sarvetnick N., Liggitt D., Pitts S. L., Hansen S. E., Stewart T. A. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell. 52:1988;773-782.
35. Sarvetnick N., Shizuru J., Liggitt D., Martin L., McIntyre B., Gregory A., Parslow T., Stewart T. A. Loss of islet tolerance induced by β-cell expressing interferon-γ Nature. 346:1990;844-847.
36. Geiger K., Howes E., Gallina M., Huang X. J., Travis G. H., Sarvetnick N. Transgenic mice expressing IFNγ in the retina develop inflammation of the eye and photoreceptor loss. Invest. Ophthalmol. Vis. Sci. 35:1994;2667-2681.
37. Egwuagu C. E., Sztein J., Chan C. C., Reid W., Mahdi R., Nussenblatt R. B., Chepelinsky A. B. Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression. Invest. Ophthalmol. Vis. Sci. 35:1994;332-341.
38. Egwuagu C. E., Sztein J., Chan C. C., Mahdi R., Nussenblatt R. B., Chepelinsky A. B. γInterferon expression disrupts lens and retinal differentiation in transgenic mice. Dev. Biol. 166:1994;557-568.
39. Horwitz M. S., Evans C. F., McGavern D. B., Rodriguez M., Oldstone M. B. A. Primary demyelination in transgenic mice expressing interferon-γ Nature Med. 3:1997;1037-1041.
40. Nudel U., Calvo J. M., Levy Z. The nucleotide sequence of the rat cytoplasmic β-actin gene. Nucleic Acids Res. 11:1983;1759-1771.
41. Barran P. A., McMaster W. R. DNA sequence analysis of the rat RT1. Immunogenetics. 26:1988;6-62.
42. Kita Y., Takashi T., Iigo Y., Tamatani T., Miyasaka M., Horiuchi T. Sequence and expression of ICAM-1. Biochim. Biophys. Acta. 1131:1992;108-110.
43. Shirai T., Shimuzu N. S., Horiguchi S., Ito H. Cloning and expression inE. coli. Agric. Biol. Chem. 53:1989;1733-1736.
44. Quax-Jeuken Y., Quax W., van Rens G., Khan P. M., Bloemendal H. Complete structure of the αB-crystallin gene: Conservation of the exon-intron distribution in the two nonlinked α-crystallin genes. Proc. Natl. Acad. Sci. USA. 82:1985;5819-5823.
45. Lok S., Breitman M. L., Chepelinsky A. B., Piatigorsky J., Gold R. J. M., Tsui L.-C. Lens-specific promoter activity of a mouse γ-crystallin gene. Mol. Cell. Biol. 5:1985;2221-2230.
46. Gorin M. B., Yancey S. B., Cline J., Ravel J.-P., Horwitz J. The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA cloning. Cell. 39:1984;49-59.
47. White T. W., Bruzzone R., Goodenough D. A., Paul D. L. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol. Biol. Cell. 3:1992;711-720.
48. Paul D. L., Ebihara L., Takemoto L. J., Swenson K. I., Goodenough D. A. Connexin 46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J. Cell Biol. 115:1991;1077-1089.
49. Chepelinsky A. B., King C. R., Zelenka P. S., Piatigorsky J. Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5′-flanking sequences of the murine αA-crystallin gene in explanted chicken lens epithelia. Proc. Natl. Acad. Sci. USA. 82:1985;2334-2338.
50. Nussenblatt R. B., Whitcup S. M., Palestine A. G. Uveitis: Fundamental and Clinical Practice. 1996;Mosby-Year Book, St. Louis. p. 32-38.
51. Kumar A., Commane M., Flickinger T. W., Horvath C. M., Stark G. R. Defective TNFα-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science. 278:1997;1630-1632.
52. Rosenbaum J. T., McDevitt H. O., Guss R. B., Egbert P. R. Endotoxin-induced uveitis in rats as a model for human disease. Nature. 286:1980;611-613.