Activation of PKC increases Na+-K+ pump current in ventricular myocytes from guinea pig heart

Pflugers Archiv European Journal of Physiology

Volumn 437, Issue 5, 1999, Pages 643-651

  Gao, J ^a   Mathias, R T ^a   Cohen, I S ^a   Wang, Y ^a   Sun, X ^a   Baldo, G J ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Cardiac ventricular myocytes; Na+ K+ pump; PKC

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIOCTANOIN; ENZYME INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL;

ALGORITHMS; ANIMALS; CALCIUM; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; GUINEA PIGS; HEART; HEART VENTRICLES; MEMBRANE POTENTIALS; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE;

EID: 0032938032     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050828     Document Type: Article

References (27)

1. Debernardi MA, Munshi R, Yoshimura M, Cooper DMF, Brooker G (1993) Predominant expression of type-VI adenylate cyclase in C6-2B rat glioma cells may account for inhibition of cyclic AMP accumulation by calcium. Biochem J 293:325-328
2. 2+ inhibition of beta-adrenergic receptor-and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C. Mol Pharmacol 43:451-458
3. Eisner DA (1986) The Na-K pump in cardiac muscle. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system: scientific foundations. Raven Press, New York, pp 489-507
4. Ertl R, Jahnel U, Nawrath H, Carmeliet E, Vereecke J (1991) Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats. Naunyn-Schmiedeberg's Arch Pharmacol 344:574-581
5. Faux MC, Scott JD (1996) Molecular glue: kinase anchoring and scaffold proteins. Cell 85:9-12
6. Gadsby DC, Nakao M (1989) Steady state current-voltage relationship of the Na-K pump in guinea-pig ventricular myocytes. J Gen Physiol 94:511-537
7. + pump in guinea-pig ventricular myocytes. J Physiol (Lond) 449:689-704
8. +pump current in guinea pig ventricular myocytes by a cAMP dependent PKA pathway. J Physiol (Lond) 477:373-380
9. Gao J, Mathias RT, Cohen IS, Baldo GJ (1995) Two functionally different Na/K-pumps in cardiac ventricular myocytes. J Gen Physiol 106:995-1030
10. + pump current-voltage relationship in guinea-pig ventricular myocytes. J Physiol (Lond) 494:697-708
11. Gao J, Cohen IS, Mathias RT, Baldo GJ (1998) The inhibitory effect of β-stimulation on Na/K pump current in guinea pig ventricular myocytes is mediated by a cAMP-dependent PKA pathway. Pflügers Arch 435:479-484
12. Isenberg G, Klöckner U (1982) Calcium tolerant ventricular myocytes prepared by preincubation in a "KB Medium". Pflügers Arch 395:6-18
13. S-mediated stimulation of the cyclic AMP pathway. Biochem J 313:109-118
14. Liu J, Oh P, Horner T, Rogers RA, Schnitzer JE (1997) Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains. J Biol Chem 272:7211-7222
15. Newton AC (1995) Protein kinase C: structure, function, and regulation. J Biol Chem 270:28495-28498
16. Newton AC (1996) Protein kinase C: ports of anchor in the cell. Curr Biol 6:806-809
17. K via a pertussis toxin-sensitive pathway. Biophys J 54:219-225
18. Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569-572
19. ++ dependent protein kinase. Biochem Biophys Res Commun 135:397-402
20. Terzic A, Anagnostopoulos T, Vogel SM (1991) Opposite modulation of ouabain cardiotoxicity by hexamethyleneamiloride and phenylephrine. Naunyn Schmiedeberg's Arch Pharmacol 343:511-518
21. 2+ exchange activity. Am J Physiol 256:C1273-C1276
22. Walaas SI, Greengard P (1991) Protein phosphorylation and neuronal function. Pharmacol Rev 43:299-349
23. + pump current in guinea pig ventricular myocytes. J Physiol (Lond) 509.1:117-128
24. Wilde AAM, Kleber AG (1991) Effect of norepinephrine and heart rate on intracellular sodium activity and membrane potential in beating guinea pig ventricular muscle. Circ Res 68:1482-1489
25. 1b-adrenoceptor-mediated stimulation of Na-K pump current in adult rat ventricular myocytes. Am J Physiol 264:H1315-H1318
26. 2+-dependent protein kinase from heart. 1. Purification and general properties. J Biol Chem 257:8481-8488
27. Zaza A, Kline R, Rosen M (1990) Effects of alpha-adrenergic stimulation on intracellular sodium activity and automaticity in canine Purkinje fibers. Circ Res 66:416-426