Immunohistochemical assessment of constitutive and inducible heat-shock protein 70 and ubiquitin in human cerebellum and caudate nucleus

Molecular and Chemical Neuropathology

Volumn 35, Issue 1-3, 1998, Pages 97-117

  Tytell, Michael ^a   Brown, William R ^a   Moody, Dixon M ^a   Challa, Venkata R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Formaldehyde fixation; Hsc70; Hsp70; Human brain; Immunohistochemistry; Infarct; Rat brain; Stress proteins; Ubiquitin; Western blot

Indexed keywords

HEAT SHOCK PROTEIN; UBIQUITIN;

ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CEREBELLUM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RAT;

ADULT; ANIMALS; ANTIBODY SPECIFICITY; AUTOPSY; CARRIER PROTEINS; CATTLE; CAUDATE NUCLEUS; CEREBELLUM; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE FIXATION; UBIQUITINS;

ANIMALIA;

EID: 0032936977     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02815118     Document Type: Article

References (59)

1. Agarraberes F. A., Terlecky S. R., and Dice J. F. (1997) An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J. Cell Biol 137, 825-834.
2. Barbe M. F., Tytell M., Gower D. J., and Welch W. J. (1988) Hyperthermia protects against light damage in the rat retina. Science 241, 1817-1820.
3. Beckman R. P., Mizzen L. A., and Welch W. J. (1990) Interaction of hsp70 with newly synthesized proteins: Implications for protein folding and assembly. Science 248, 850-854.
4. Beckmann R. P., Lovett M., and Welch W. J. (1992) Examining the function and regulation of hsp 70 in cells subjected to metabolic stress. J. Cell Biol. 117, 1137-1150.
5. Bell M. A. and Scarrow W. G. (1984) Staining for microvascular alkaline phosphatase in thick celloidin sections of nervous tissue: morphometric and pathologic applications. Microvasc. Res. 27, 189-203.
6. Bizzi A., Schaetzle B., Patton A., Gambetti P., and Autilio-Gambetti L. (1991) Axonal transport of two major components of the ubiquitin system: Free ubiquitin and ubiquitin carboxyl-terminal hydrolase PGP 9.5. Brain Res. 548, 292-299.
7. Bond U. and Schlesinger M. J. (1985) Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Mol. Cell. Biol. 5, 949-956.
8. Brown C. R., Martin R. L., Hansen W. J., Beckmann R. P., and Welch W. J. (1993) The constitutive and stress inducible forms of Hsp70 exhibit functional similarities and interact with one another in an ATP-dependent fashion. J. Cell Biol 120, 1101-1112.
9. Brown I. R. (1994) Induction of heat shock genes in the mammalian brain by hyperthermia and tissue injury, in Heat Shock Proteins in the Nervous System (Mayer J. and Brown I., eds.), pp. 32-53, Academic, London.
10. Buchner J. (1996) Supervising the fold-functional principals of molecular chaperones. FASEB J. 10, 10-19.
11. Chopp M., Chen H., Ho K.-L., Dereski M. O., Brown E., Hetzel F. W., et al. (1989) Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat. Neurology 39, 1396-1398.
12. Chopp M., Li Y., Zhang Z. G., and Garcia J. H. (1993) Distribution of the 72-kDa heat shock protein and cell damage after experimental focal cerebral ischemia and subarachnoid hemorrhage in rat brain. Neurosci. Res. Commun. 12, 165-174.
13. Cisse S., Perry G., Lacoste-Royal G., Cabana T., and Gauvreau D. (1993) Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains. Acta Neuropathol. 85, 233-240.
14. Craig E. A. and Gross C. A. (1991) Is Hsp70 the cellular thermometer? Trends Biochem. 16, 135-140.
15. Craig E. A., Baxter B. K., Becker J., Halladay J., and Ziegelhoffer T. (1994) Cytosolic Hsp70s of Saccharomyces cerevisiae: roles in protein synthesis, protein translocation, proteolysis, and regulation, in The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto R. I., Tissières A., and Georgopoulos C., eds.), pp. 31-52). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
16. Dean D. O., Kent C. R., and Tytell M. (1997) Heat shock protein 70 immunoreactivity in the normal, unstressed, rat eye: a comparison of constitutive and inducible forms. Soc. Neurosci. Abstracts 23, part 1, 89.
17. Dutcher S. A., Underwood B. D., Walker P. D., Diaz F. G., and Michael D. B. (1998) Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury. J. Neurotrauma 15, 411-420.
18. Finley D. and Chau V. (1991) Ubiquitination. Annu. Rev. Cell Biol. 7, 25-69.
19. Frydman J. and Hartl F.-U. (1994) Molecular chaperone functions of Hsp70 and Hsp60 in protein folding, in The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto R. I., Tissières A., and Georgopoulos C., eds.), pp. 251-283). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
20. Frydman J. and Hartl F.-U. (1996) Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms. Science 272, 1497-1502.
21. Gass P., Herdegen T., Bravo R., and Kiessling M. (1994) High induction threshold for transcription factor KROX-20 in the rat brain: partial co-expression with heat shock protein 70 following limbic seizures. Mol. Brain Res. 23, 292-298.
22. Gehring W. J. and Wehner R. (1995) Heat shock protein synthesis and thermotolerance in Cataglyphis, an ant from the Sahara desert. Proc. Natl. Acad. Sci. USA 92, 2994-2998.
23. Johnson A. D., Berberian P. A., Tytell M., and Bond M. G. (1995) Differential distribution of 70-kD heat shock protein in atherosclerosis - Its potential role in arterial SMC survival. Arteriosclerosis Thromb. Vasc. Biol. 15, 27-36.
24. Kato S., Hirano A., Umahara T., Kato M., Herz F., and Ohama E. (1992) Comparative immunohistochemical study on the expression of alpha B crystallin, ubiquitin and stress-response protein 27 in ballooned neurons in various disorders. Neuropathol. Appl. Neurobiol. 18, 335-340.
25. Kato H., Chen T., Liu X.-H., Nakata N., and Kogure K. (1993) Immunohistochemical localization of ubiquitin in gerbil hippocampus with induced tolerance to ischemia. Brain Res. 619, 339-343.
26. Kawagoe J., Abe K., Sato S., Nagano I., Nakamura S., and Kogure K. (1992) Distributions of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient focal ischemia in rat brain. Brain Res. 587, 195-202.
27. Kida E. and Barcikowska M. (1992) Ubiquitin expression in globose tangles in the locus coeruleus in brains of patients with Alzheimer's and Parkinson's diseases. Neurosci. Lett. 136, 59-62.
28. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227, 680-685.
29. Li Y., Chopp M., Garcia J. H., Yoshida Y., Zhang Z. G., and Levine S. R. (1992a) Distribution of the 72-kd heat-shock protein as a function of transient focal cerebral ischemia in rats. Stroke 23, 1292-1298.
30. Li Y., Chopp M., Yoshida Y., and Levine S. R. (1992b) Distribution of the 72-kDa heat-shock protein in rat brain after hyperthermia. Acta Neuropathol. 84, 94-99.
31. Lowe J., Blanchard A., Morrell K., Lennox G., Reynolds L., Billett M., et al. (1988) Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and Mallory bodies in alcoholic liver disease. J. Pathol. 155, 9-15.
32. Lowenstein D. H., Chan P. H., and Miles M. F. (1991) The stress protein response in cultured neurons: Characterization and evidence for a protective role in excitotoxicity. Neuron 7, 1053-1060.
33. Magnusson K. and Wieloch T. (1989) Impairment of protein unbiquitination may cause delayed neuronal death. Neurosci. Lett. 96, 264-270.
34. Manetto V., Perry G., Tabaton M., Mulvihill P., Fried V. A., Smith H. T., et al. (1988) Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 85, 4501-1505.
35. Manzerra P, Rush S. J., and Brown I. R. (1993) Temporal and spatial distribution of heat shock mRNA and protein (hsp70) in the rabbit cerebellum in response to hyperthermia. J. Neurosci. Res. 36, 480-490.
36. Massa S. M., Swanson R. A., and Sharp F. R. (1996) The stress gene response in brain. Cerebrovasc. Brain Metab. Rev. 8, 95-158.
37. Mayer R. J., Arnold J., Laszlo L., Landon M., and Lowe J. (1991) Ubiquitin in health and disease. Biochim. Biophys. Acta 1089, 141-157.
38. Migheli A., Attanasio A., Pezzulo T., Gullotta F., Giordana M. T., and Schiffer D. (1992) Age-related ubiquitin deposits in dystrophic neurites: An immunoelectron microscopic study. Neuropathol. Appl. Neurobiol. 18, 3-11.
39. Miller E. K., Raese J. D., and Morrison-Bogorad M. (1991) Expression of heat shock protein 70 and heat shock cognate 70 messenger RNAs in rat cortex and cerebellum after heat shock or amphetamine treatment. J. Neurochem. 56, 2060-2071.
40. Minowada G. and Welch W. J. (1995) Clinical implications of the stress response. J. Clin. Invest. 95, 3-12.
41. Mitchell D., Ibrahim S., and Gusterson B. A. (1985) Improved immunohistochemical localization of tissue antigens using modified methacarn fixation. J. Histochem. Cytochem. 33, 491-495.
42. Moody D. M., Bell M. A., Challa V. R., Johnston W. E., and Prough D. S. (1990) Brain microemboli during cardiac surgery or aortography. Ann. Neurol. 28, 477-186.
43. Morrison-Bogorad M., Zimmerman A. L., and Pardue S. (1995) Heat-shock 70 messenger RNA levels in human brain: Correlation with agonal fever. J. Neurochem. 64, 235-246.
44. Nowak T. S. Jr. and Jacewicz M. (1994) The heat shock/stress response in focal cerebral ischemia. Brain Pathol. 4, 67-76.
45. Nowak T. S. Jr., Bond U., and Schlesinger M. J. (1990) Heat shock RNA levels in brain and other tissues after hyperthermia and transient ischemia. J. Neurochem. 54, 451-458.
46. Pappolla M. A., Omar R., and Sara B. (1989) The "normal" brain - "Abnormal" ubiquitinated deposits highlight an age-related protein change. Am. J. Pathol. 135, 585-591.
47. Parsell D. A. and Lindquist S. (1994) Heat shock proteins and stress tolerance, in The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto R. I., Tissières A., and Georgopoulos C., eds.), pp. 457-494, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
48. Riabowol K. T., Mizzen L. A., and Welch W. J. (1988) Heat shock is lethal to fibroblasts microinjected with antibodies against Hsp70. Science 242, 433-436.
49. Schmidt M. L. and Trojanowski J. Q. (1995) Immunohistochemical detection of the effects of toxic injury on the central nervous system. Neurochem. Int. 26, 145-153.
50. Sharp F. R., Lowenstein D., Simon R., and Hisanaga K. (1991) Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction. J. Cereb. Blood Flow Metab. 11, 621-627.
51. Tanguay R. M., Wu Y., and Khandjian E. W. (1993) Tissue-specific expression of heat shock proteins of the mouse in the absence of stress. Dev. Gen. 14, 112-118.
52. Towbin H., Staehelin T., and Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
53. Tytell M. (1994) Heat shock proteins in the retina and optic nerve, in Heat Shock Proteins in the Nervous System (Mayer J. and Brown I., eds.), pp. 83-100, Academic, New York.
54. Tytell M., Nosel E. R., and Glazier S. S. (1996) Hsc70 in hippocampus from human epilepsy patients, in Molecular Chaperones & The Heat Shock Response, p. 298. Cold Spring Harbor Press, Cold Spring Harbor, NY.
55. Vass K., Welch W. J., and Nowak T. S., Jr. (1988) Localization of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropathol. 77, 128-135.
56. Wang G. P., Khatoon S., Iqbal K., and Grundke-Iqbal I. (1991) Brain ubiquitin is markedly elevated in Alzheimer disease. Brain Res. 566, 146-151.
57. Welch W. J. and Feramisco J. R. (1985) Rapid purification of mammalian 70,000-dalton stress proteins: Affinity of the proteins for nucleotides. Mol. Cell. Biol. 5, 1229-1237.
58. Welsh F. A., Moyer D. J., and Harris V. A. (1992) Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brain. J. Cereb. Blood Flow Metab. 12, 204-212.
59. Yamashita K., Eguchi Y., Kajiwara K., and Ito H. (1991) Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus. Stroke 22, 1574-1581.