Paradoxical effects of pirenzepine on parasympathetic activity in chronic heart failure and control

International Journal of Cardiology

Volumn 68, Issue 1, 1999, Pages 47-56

  Hayano, Tomoko ^a   Shimizu, Akihiko ^a   Ikeda, Yasuhiro ^a   Yamamoto, Takeshi ^a   Yamagata, Toshihiko ^a   Ueyama, Takeshi ^a   Furutani, Yuji ^a   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic heart failure; Low dose pirenzepine; Vagal activity

Indexed keywords

PIRENZEPINE;

ADULT; AGED; ARTICLE; CHOLINERGIC ACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HEART FAILURE; HOLTER MONITORING; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; RR INTERVAL; VAGUS NERVE STIMULATION;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHRONIC DISEASE; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE, CONGESTIVE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; PARASYMPATHOLYTICS; PIRENZEPINE; RADIOIMMUNOASSAY; VAGUS NERVE;

EID: 0032936708     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(98)00335-0     Document Type: Article

References (26)

1. Wellstein A., Pitschner H.F. Complex dose response curves of atropine in man explained by different functions of M1- and M2-cholinoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 338:1988;19-27.
2. Pitschner H.F., Wellstein A. Dose-response curves of pirenzepine in man in relation to M1- and M2-cholinoceptor occupancy. Naunyn-Schmiedeberg's Arch. Pharmacol. 338:1988;207-210.
3. Giraido E., Martos F., Gomez A., Garcia A., Vigano M.A., Ladinsky H. Characterization of muscarinic receptor subtypes in human tissue. Life Sci. 43:1988;1507-1515.
4. Hammer R., Berrie C.P., Birdsall N.J.M., Burgen A.S.V., Hulme E.C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 283:1980;90-92.
5. Poller U., Nedelka G., Radke J., Ponicke K., Brodde O.E. Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers. J. Am. Coll. Cardiol. 29:1997;187-193.
6. Eckberg D.L., Drabinsky M., Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. New Engl. J. Med. 285:1971;877-883.
7. Porter T.R., Eckberg D.L., Fritsch I.M.et al. Autonomic pathophysiology in heart failure patients. Sympathetic-cholinergic interrelation. J. Clin. Invest. 85:1990;1362-1371.
8. Kleiger R.E., Miller J.R., Bigger J.T., Moss A.J. Multicenter Post-Infarction Research Group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am. J. Cardiol. 59:1987;256-262.
9. Bigger J.T., Fleiss J.L., Steinman R.C., Rolinitzky L.M., Kleiger R.E., Rottman J.N. Frequency-domain measures of heart period variability and mortality after myocardial infarction. Circulation. 85:1992;164-171.
10. La Rovere M.I., Specchia G., Mortara A., Schwartz P.J. Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction: a prospective study. Circulation. 78:1988;816-824.
11. Vanoli B., De Ferrari G.M., Stramba-Badiale M., Hull S.S., Foreman R.D., Schwartz P.J. Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ. Res. 68:1991;1471-1481.
12. La Rovere M.T., Mortara A., Pantaleo P., Maestri R., Cobelli F., Tavazzi L. Scopolamine improves autonomic balance in advanced congestive heart failure. Circulation. 90:1994;838-843.
13. De Ferrari G.M., Salvati P., Grossoni M.et al. Pharmacologic modulation of the autonomic nerve system in the prevention of sudden cardiac death. A study with propranolol, methacoline and oxotrinorine in conscious dogs with a healed myocardial infarction. J. Am. Coll. Cardiol. 21:1993;283-290.
14. Pedretti R.F.E., Colombo E., Braga S.S., Ballardini L., Caru B. Effects of oral pirenzepine on heart rate variability and baroreceptor reflex sensitivity after acute myocardial infarction. J. Am. Coll. Cardiol. 25:1995;915-921.
15. Pomeranz B., Maculay R.I.B., Caudill M.A.et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am. J. Physiol. 248:1985;H151-H153.
16. Akselrod S., Gordon D., Ubel F.A., Shannon D.C., Barger A.C., Cohen R.I. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat to beat cardiovascular control. Science. 213:1981;220-222.
17. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 1996;93:1043-65.
18. Homon C.A., Esber H.J., Zavorskas P., Tanswell P., Farina P.R. A selective radioimmunoassay for the determination of pirenzepine in plasma and urine. Ther. Drug Monit. 9:1987;236-242.
19. Stockbrugger R, Jaup B, Dotevall D, Bozler G. Inhibition of gastric acid secretion by pirenzepine in man. In: Blum AL, Hammer R, editors. Die behandlung des ulcus pepticum mit pirenzepin. Munich: Karl Demeter, 1979:66-72.
20. Saul J.P., Arai Y., Berger R.D., Lilly L.S., Colucci W.S., Cohen R.I. Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am. J. Cardiol. 61:1988;1292-1299.
21. Pipilis A., Flather M., Ormerod O., Sleight P. Heart rate variability in acute myocardial infarction and its association with infarct site and clinical course. Am. J. Cardiol. 67:1991;1137-1139.
22. Guo G.B., Abboud F.M. Angiotensin II attenuates baroreflex control of heart rate and sympathetic activity. Am. J. Physiol. Heart Circ. Physiol. 246:1984;H80-H89.
23. Maisel A.S., Scott N.A., Motulsky R.I.et al. Elevation of plasma neuropeptide Y levels in congestive heart failure. Am. J. Med. 86:1989;43-48.
24. Potter E.K., Ulman L.G. Neuropeptides in sympathetic nerves affect vagal regulation of the heart. News Physiol. Sci. 9:1994;174-177.
25. Reardon M., Malik M. Changes in heart rate variability with age. Pacing Clin. Electrophysiol. 19:1996;1863-1866.
26. Roth G.S. Hormone receptor changes during adulthood and senescence: significance for aging research. Fed. Proc. 38:1979;1910-1914.