Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers

Journal of the American College of Cardiology

Volumn 29, Issue 1, 1997, Pages 187-193

  Poller, U ^a   Nedelka, G ^a   Radke, J ^a   Ponicke, K ^a   Brodde, O E ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; MUSCARINIC RECEPTOR; PHENYLEPHRINE; PIRENZEPINE;

ADULT; AGE; AGED; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART FUNCTION; HEART RATE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; VOLUNTEER;

EID: 0031016002     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00437-8     Document Type: Article

References (41)

1. JR Docherty Cardiovascular responses in ageing Pharmacol Rev 42 1990 103 125
2. B Folkow A Svanborg Physiology of cardiovascular aging Physiol Rev 73 1993 725 764
3. B Gribbin TG Pickering P Sleight R Peto Effect of age and high blood pressure on baroreflex sensitivity in man Circ Res 29 1971 424 430
4. KJ Collins AJ Exton-Smith AN James DJ Oliver Functional changes in autonomic nervous responses with ageing Age Ageing 9 1980 17 24
5. HL Elliott DJ Sumner K McLean JL Reid Effect of age on the responsiveness of vascular α-adrenoceptors in man J Cardiovasc Pharmacol 4 1982 388 392
6. K McGarry M Laher D Fitzgerald J Horgan E O’Brien K O’Malley Baroreflex function in elderly hypertensives Hypertension 5 1983 763 766
7. H Kirchheim Systemic arterial baroreceptor reflexes Physiol Rev 56 1976 100 176
8. M Kollai G Jokkel I Bonyhay J Tomcsanyi A Naszlady Relation between baroreflex sensitivity and cardiac vagal tone in humans Am J Physiol 35 1994 H21 27
9. GA Ford OFW James Effect of “autonomic blockade” on cardiac β-adrenergic chronotropic responsiveness in healthy elderly and endurance-trained elderly subjects Clin Science 87 1994 297 302
10. GS Roth Hormone receptor changes during adulthood and senescence significance for ageing research Fed Proc 38 1979 1910 1914
11. EG Lakatta Cardiovascular regulatory mechanisms in advanced age Physiol Rev 73 1993 413 467
12. O-E Brodde H-R Zerkowski D Schranz Age-dependent changes in the β-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium J Cardiovasc Pharmacol 26 1995 20 26
13. M White R Roden W Minobe Age-related changes in β-adrenergic neuroeffector systems in human heart Circulation 90 1994 1225 1238
14. 2-cholinoceptors Naunyn Schmiedebergs Arch Pharmacol 338 1988 19 27
15. 2-cholinoceptor occupancy Naunyn Schmiedebergs Arch Pharmacol 338 1988 207 210
16. R Hammer CP Berrie NJM Birdsall ASV Burgen EC Hulme Pirenzepine distinguishes between different subclasses of muscarinic receptors Nature 183 1980 90 92
17. A Daul U Hermes RF Schäfers R Wenzel C von Birgelen O-E Brodde The β-adrenoceptor subtypes mediating adrenaline- and dobutamine-induced blood pressure and heart rate changes in healthy volunteers J Clin Pharmacol Ther 33 1995 140 148
18. AM Weissler RP Lewis RF Leighton The systolic time intervals as a measure of left ventricular performance in man PN Yu JF Goodwin Progress in Cardiology Vol. 1. 1972 Lea & Fiebinger Philadelphia 155 183
19. RP Lewis SE Rittgers WF Forester H Boudoulas A critical review of systolic time intervals Circulation 56 1977 146 158
20. R Erbel GG Belz Untersuchung zur Meßmethode der systolischen Zeitintervalle a study of the analysis of systolic time intervals Z Kardiol 66 1977 433 435
21. SJ Warrington K Weerasuriya CD Burgess Correction of systolic time intervals for heart rate a comparison of individual with population derived regression equations Br J Clin Pharmacol 26 1988 155 165
22. 1-adrenoceptor antagonist treatment J Am Coll Cardiol 23 1995 1224 1233
23. HS Smyth P Sleight GW Pickering Reflex regulation of arterial pressure during sleep in man a quantitative method of assessing baroreflex sensitvity Circ Res 24 1969 109 121
24. A Daul M Elter-Schulz U Poller Dose-dependent separation of dopaminergic and adrenergic effects of epinine in healthy volunteers Naunyn Schmiedebergs Arch Pharmacol 352 1995 429 437
25. HF Pitschner B Schulte A Neuzner A Wellstein D Palm M Schlepper Subtypen muskarinischer Rezeptoren—Aspekte ihrer physiologischen Bedeutung für die Steuerung der Herzfrequenz beim Menschen Z Kardiol 83 1994 9 20
26. K Imai H Sato M Hori Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure J Am Coll Cardiol 24 1994 1529 1535
27. B Schulte C Volz-Zang E Mutschler AF-DX 116, a cardioselective muscarinic antagonist in humans pharmacodynamic and pharmacokinetic properties Clin Pharmacol Ther 50 1991 372 378
28. W Scheidt M Böhm B Schneider G Autenrieth E Erdmann Cholinergic baroreflex vasodilatation defect in heart transplant recipients due to denervation of the ventricular baroreceptor Am J Cardiol 69 1992 247 252
29. AE Epstein BI Hirschowitz JK Kirklin KA Kirk VJ Plumb Evidence for a central site of action to explain the negative chronotropic effect of atropine studies on the human transplanted heart J Am Coll Cardiol 15 1990 1610 1617
30. E Giraldo F Martos A Gomez Characterization of muscarinic receptor subtypes in human tissue Life Sci 43 1988 1507 1515
31. NM Deighton S Motomura D Borquez HR Zerkowski N Doetsch O-E Brodde Muscarinic cholinoceptors in the human heart, demonstration, subclassification and distribution Naunyn Schmiedebergs Arch Pharmacol 341 1990 14 21
32. RH Kennedy E Seifen Ageing effects on chronotropic actions of muscarinic agonists in isolated rat atria Mech Ageing Dev 51 1990 81 87
33. MG Ziegler CR Lake IJ Kopin Plasma noradrenaline increases with age Nature 261 1976 333 335
34. AV Ng R Callister DG Johnson DR Seals Age and gender influence muscle sympathetic nerve activity at rest in healthy humans Hypertension 21 1993 498 503
35. DG Wallin W Delius K-E Hagbarth Comparison of sympathetic nerve activity in normotensive and hypertensive subjects Circ Res 33 1973 9 21
36. Y Yamada E Miyajima AT Matsukawa M Ishii Age-related changes in muscle sympathetic nerve activity in essential hypertension Hypertension 13 1989 870 877
37. M White FHH Leenen Ageing and cardiovascular responsiveness to β-agonist in humans role of changes in β-receptor responses versus baroreflex activity Clin Pharmacol Ther 56 1994 543 553
38. iin human hearts with dilated but not ischemic cardiomyopathy Circulation 82 1990 1249 1265
39. W Von Scheidt M Böhm A Stäblein G Autenrieth E Erdmann Antiadrenergic effect of M-cholinoceptor stimulation on human ventricular contractility in vivo Am J Physiol 263 1992 H1927 1931
40. MN Levy Sympathetic-parasympathetic interactions in the heart Circ Res 290 1971 437 445
41. C de Mey GG Belz U Nixdorf Relative sensitivity of four noninvasive methods in assessing systolic cardiovascular effects of isoproterenol in healthy volunteers Pharmacol Ther 52 1992 609 619