Selective catalytic hydrogenation of γ-amino α,β-unsaturated esters in the presence of hydrogenable protecting groups

Synthesis

Volumn , Issue 5, 1999, Pages 873-877

  Misiti, Domenico ^a   Zappia, Giovanni ^a   Delle Monache, Giuliano ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

3 Pd C; Chemoselective hydrogenation; Protected amino acids; Amino , unsaturated esters

Indexed keywords

BENZYL ESTER; ESTER; ESTER DERIVATIVE; ETHER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; HYDROGENATION; MELTING POINT; OPTICAL ROTATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; REDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0032936234     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-3471     Document Type: Article

References (21)

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18. The solvent was dried prior the use according to: Perrin, D.D.; Armarego, W. L. F. Purification of Laboratory Chemicals, Pergamon Press: Oxford, 1988. Commercial EtOAc gave lower selectivity.
19. 4.
20. 3, respectively.
21. No attempts have been made so far to scale-up the method.