Regulation of actin cytoskeleton in lymphocytes: PKC-δ disrupts IL-3- induced membrane ruffles downstream of Rac1

Journal of Cellular Physiology

Volumn 179, Issue 2, 1999, Pages 157-169

  Romanova, Larisa Y ^a,c   Alexandrov, Ivan A ^b   Blagosklonny, Mikhail V ^a   Nordan, Richard P ^b   Garfield, Susan ^a   Acs, Peter ^a   Nguyen, Phuongmai ^a   Trepel, Jane ^a   Blumberg, Peter M ^a   Mushinski, J Frederic ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; FOCAL ADHESION KINASE; INTERLEUKIN 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; RAF PROTEIN; RHO FACTOR; TUBULIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CELL SHAPE; CELL STRUCTURE; CYTOSKELETON; ENZYME ACTIVATION; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ACTINS; ANIMALS; B-LYMPHOCYTES; CELL LINE; CELL MEMBRANE; CELL SIZE; CYTOCHALASIN D; CYTOSKELETON; GTP-BINDING PROTEINS; INDOLES; INTERLEUKIN-3; ISOENZYMES; MALEIMIDES; MICE; PHENOTYPE; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RAC GTP-BINDING PROTEINS; TETRADECANOYLPHORBOL ACETATE; TUBULIN;

EID: 0032935740     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199905)179:2<157::AID-JCP6>3.0.CO;2-4     Document Type: Article

References (45)

1. Adamson P, Paterson HF, Hall A. 1992. Intracellular localization of the p21 rho proteins. J Cell Biol 119:617-627.
2. Aihara H, Asaoka Y, Yoshida K, Nishizuka Y. 1991. Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage. Proc Natl Acad Sci USA 88:11062-11066.
3. Allen WE, Jones GE, Pollard JW, Ridley AJ. 1997. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci 110:707-720.
4. Avila J. 1992. Microtubule functions. Life Sci 50:327-334.
5. Avraham S, Avraham H. 1997. Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells. Leuk Lymphoma 27:247-256.
6. Bretscher A. 1993. Microfilaments and membranes. Curr Opin Cell Biol 5:653-660.
7. Chen Q, Kinch MS, Lin TH, Burridge K, Juliano RL. 1994. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 269:26602-26605.
8. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. 1994. The small GTP-binding protein rho regulates a phosphoinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-513.
9. Coppock DL, Tansey JB, Nathanson L. 1992. 12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34 cdc2. Cell Growth Differ 3:485-494.
10. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
11. DeBell KE, Conti A, Alava MA, Hoffman T, Bonvini E. 1992. Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes. J Immunol 149:2271-2280.
12. Dell'Aquila ML, Nguyen HT, Herald CL, Pettit GR, Blumberg PM. 1987. Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells. Cancer Res 47:6006-6009.
13. Downey GP, Chan CK, Lea P, Takai A, Grinstein S. 1992. Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C. J Cell Biol 116:695-706.
14. Goodnight JA, Mischak H, Kolch W, Mushinski JF. 1995. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes. J Biol Chem 270:9991-10001.
15. Guan JL. 1997. Focal adhesion kinase in integrin signaling. Matrix Biol 16:195-200.
16. Gyoeva FK, Gelfand VI. 1991. Coalignment of vimentin intermediate filaments with microtubules depends on kinesin. Nature 353:445-448.
17. Hall C, Sin WC, Teo M, Michael GJ, Smith P, Dong JM, Lim HH, Manser E, Spurr NK, Jones TA, Lim L. 1993. Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21 rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol Cell Biol 13:4986-4998.
18. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. 1995. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82:643-653.
19. Hiregowdara D, Avraham H, Fu Y, London R, Avraham S. 1997. Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. J Biol Chem 272:10804-10810.
20. Jaken S, Leach K, Klauck T. 1989. Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J Cell Biol 109:697-704.
21. Kraft AS, Smith JB, Berkow RL. 1986. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc Natl Acad Sci USA 83:1334-1338.
22. Lamarche N, Tapon N, Stowers L, Burbelo PD, Aspenstrom P, Bridges T, Chant J, Hall A. 1996. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65 PAK and the JNK/SAPK MAP kinase cascade. Cell 87:519-529.
23. Lilly M, Tompkins C, Brown C, Pettit G, Kraft A. 1990. Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin. Cancer Res 50:5520-5525.
24. Lu Z, Hornia A, Jiang YW, Zang Q, Ohno S, Foster DA. 1997. Tumor promotion by depleting cells of protein kinase C-δ. Mol Cell Biol 17:3418-3428.
25. Melamed I, Turner CE, Aktories K, Kaplan DR, Gelfand EW. 1995. Nerve growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes. J Exp Med 181:1071-1079.
26. Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF. 1993a. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-βII, -∈, -ζ, and -η. J Biol Chem 268:20110-20115.
27. Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz M, Blumberg PM, Pierce JH, Mushinski JF. 1993b. Overexpression of protein kinase C-δ and -∈ in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorgenicity. J Biol Chem 268:6090-6096.
28. Nishiyama T, Sasaki T, Takaishi K, Kato M, Yaku H, Araki K, Matsuura Y, Takai Y. 1994. Rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor-and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol Cell Biol 14:2447-2456.
29. Nobes CD, Hall A. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellopodia, and filopodia. Cell 81:53-62.
30. Olah Z, Lehel C, Jakab G, Anderson WB. 1994. A cloning and epsilon-epitope-tagging insert for the expression of polymerase chain reaction-generated cDNA fragments in Escherichia coli and mammalian cells. Anal Biochem 224:94-102.
31. Olson MF, Ashworth A, Hall A. 1995. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269:1270-1272.
32. Ridley AJ, Comoglio PM, Hall A. 1995. Regulation of scatter factor/ hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol 15:1110-1122.
33. Rodionov VI, Gyoeva FK, Tanaka E, Bershadsky AD, Vasiliev JM, Gelfand VI. 1993. Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain. J Cell Biol 123:1811-1820.
34. Romanova LY, Alexandrov IA, Schwab G, Hilbert DM, Mushinski JF, Nordan RP. 1996. Mechanism of apoptosis suppression by phorbol ester in IL-6-starved murine plasmacytomas: role of PKC modulation and cell cycle. Biochemistry 35:9900-9906.
35. Romanova LY, Alexandrov IA, Nordan RP, Blagosklonny MV, Mushinski JF. 1998. Cross-talk between protein kinase C-α and -δ: PKC-α elevates the PKC-δ protein level, altering its mRNA transcription and degradation. Biochemistry 37:5558-5565.
36. Seufferlein T, Rozengurt E. 1994. Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor. J Biol Chem 269:9345-9351.
37. Sinnett-Smith J, Zachary I, Valverde AM, Rozengurt E. 1993. Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. J Biol Chem 268:14261-14268.
38. Stokoe D, Macdonald SG, Cadwallader K, Symons M, Hancock JF. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467.
39. Stossel TP. 1993. On the crawling of animal cells. Science 260:1086-1094.
40. Suzuki K, Saido TC, Hirai S. 1992. Modulation of cellular signals by calpain. Ann N Y Acad Sci 674:218-227.
41. Szallasi Z, Denning MF, Chang EY, Rivera J, Yuspa SH, Lehel C, Olah Z, Anderson WB, Blumberg PM. 1995a. Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem Biophys Res Commun 214:888-894.
42. Szallasi Z, Kosa K, Smith CB, Dlugosz AA, Williams EK, Yuspa SH, Blumberg PM. 1995b. Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. Mol Pharmacol 47:258-265.
43. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, Kirilovsky J. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781.
44. Zachary I, Sinnett-Smith J, Turner CE, Rozengurt E. 1993. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells. J Biol Chem 268:22060-22065.
45. Zhu X, Assoian RK. 1995. Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 6:273-282.