Function of rat pancreatic islets exposed to interleukin-18 in vitro

Autoimmunity

Volumn 29, Issue 4, 1999, Pages 263-267

  Krook, Henrik ^a   Wallström, Johan ^a   Sandler, Stellan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Insulin secretion; Interleukin 12; Interleukin 18; Pancreatic islets

Indexed keywords

INSULIN; INTERLEUKIN 12; INTERLEUKIN 18; PROINSULIN; PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DNA CONTENT; GLUCOSE OXIDATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN SYNTHESIS; RAT;

EID: 0032935588     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908994745     Document Type: Article

References (23)

1. Gepts, W. (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14, 619-633.
2. Eisenbarth, G.S. (1986) Type 1 diabetes mellitus. A chronic autoimmune disease. N. Engl. J. Med. 314, 1360-1368.
3. Sandier, S., Eizirik, D.L., Svensson, C., Strandell, E., Welsh, M. and Welsh, N. (1991) Biochemical and molecular actions of interleukin-1 on pancreatic β-cells. Autoimmunity 10, 241-253.
4. Rabinovitch, A. (1994) Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43, 613-621.
5. Mandrup-Poulsen, T. (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39, 1005-1029.
6. Dao, T., Ohashi, K., Kayano, T., Kurimoto, M. and Okamura, H. (1996) Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol. 173, 230-235.
7. Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K. et al. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies of the biologic properties of the protein. J. Immunol. 156, 4274-4279.
8. Zhang, T., Kawakami, K., Qureshi, M.H., Okamura, H., Kurimoto, M. and Saito, A. (1997) Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect. Immun. 65, 3594-3599.
9. Yoshimoto, T., Okamura, H., Tagawa, Y.I., Iwakura, Y. and Nakanishi, K. (1997) Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc. Natl. Acad. Sci. USA 94, 3948-3953.
10. Rothe, H., O'Hara, R.M., Martin, S. and Kolb, H. (1997) Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)(2) Diabetologia 40, 641-646.
11. Matsumoto, S., Tsuji-Takayama, K., Aizawa, Y., Koide, K., Takeuchi, M., Ohta, T. et al. (1997) Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem. Biophys. Res. Commun. 234, 454-457.
12. Eizirik, D.L., Flodström, M., Karisen, A.E. and Welsh, N. (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39, 875-890.
13. Sandler, S., Bendtzen, K., Eizirik, D.L. and Welsh, M. (1990) Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro. Endocrinology 126, 1288-1294.
14. Sandier, S. and Welsh, N. (1993) Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1. Biochem. Biophys. Res. Commun. 195, 859-865.
15. Sternesjö, J., Bendtzen, K. and Sandler, S. (1995) Effects of prolonged exposure in vitro to interferon-gamma and tumour necrosis factor-alpha on nitric oxide and insulin production of rat pancreatic islets. Autoimmunity 20, 185-190.
16. Sandler, S. and Sternesjö, J. (1995) Interleukin-4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin-1. Cytokine 7, 296-300.
17. Sandler, S., Andersson, A. and Hellerström, C. (1987) Inhibitory effects of interleukin-1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 121, 1424-1431.
18. Heding, L.G. (1972) Determination of total serum insulin (IRI) in insulin-treated diabetic patients. Diabetologia 8, 260-266.
19. Hinegardner, R.T. (1971) An improved fluorometric assay for DNA. Anal Biochem 39, 197-201.
20. Andersson, A. and Sandler, S. (1983) Viability tests of cryopreserved endocrine pancreatic cells. Cryobiology 20, 161-168.
21. Halban, P.A., Wollheim, C.B., Blondel, B. and Renold, A.E. (1980) Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the β-cell. Biochem. Pharmacol. 29, 2625-2633.
22. Tsuji-Takayama, K., Matsumoto, S., Koide, K., Takeuchi, M., Ikeda, M., Ohta, T. et al. (1997) Interleukin-18 induces activation and association of p56(lck) and MAPK in a murine TH1 clone. Biochem. Biophys. Res. Commun. 237, 126-130.
23. + human blood mononuclear cells. J. Clin. Invest. 101, 711-721.