The URA5 gene is necessary for Histoplasma capsulatum growth during infection of mouse and human cells

Infection and Immunity

Volumn 67, Issue 2, 1999, Pages 624-629

  Retallack, Diane M ^a   Heinecke, Elizabeth L ^a   Gibbons, Reta ^b   Deepe Jr , George S ^b   Woods, Jon P ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OROTATE PHOSPHORIBOSYLTRANSFERASE; PYRIMIDINE; URACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUXOTROPHY; CELL PROLIFERATION; CONTROLLED STUDY; FUNGUS GROWTH; GENE DISRUPTION; GENE MUTATION; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ULTRAVIOLET RADIATION; VIRULENCE;

HISTOPLASMA CAPSULATUM;

EID: 0032932156     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.2.624-629.1999     Document Type: Article

References (55)

1. Bacon, G. A., T. W. Burrows, and M. Yates. 1951. The effects of biochemical mutation on the virulence of Bacterium typhimosum: the loss of virulence in certain mutants. Br. J. Exp. Pathol. 32:85-96.
2. Buchmeier, N. A., and S. J. Libby. 1996. Dynamics of growth and death within a Salmonella typhimurium population during infection of macrophages. Can. J. Microbiol. 43:29-34.
3. Bullock, W. E. 1993. Interaction between human phagocytic cells and Histoplasma capsulatum. Arch. Med. Res. 24:219-223.
4. Chaturvedi, S., P. Frame, and S. L. Newman. 1995. Macrophages from human immunodeficiency virus-positive persons are defective in host defense against Histoplasma capsulatum. J. Infect. Dis. 171:320-327.
5. Daniels, L. S., M. D. Berliner, and C. C. Campbell. 1968. Varying virulence in rabbits infected with different filamentous types of Histoplasma capsulatum. J. Bacteriol. 96:1535-1539.
6. Deepe, G. S., Jr. 1994. The immune response to Histoplasma capsulatum: unearthing its secrets. J. Clin. Med. 123:201-205.
7. Deepe, G. S., Jr. 1997. Histoplasma capsulatum: darling of the river valleys. ASM News 63:599-604.
8. Eissenberg, L. G., and W. E. Goldman. 1987. Histoplasma capsulatum fails to trigger release of superoxide from macrophages. Infect. Immun. 55:29-34.
9. Eissenberg, L. G., and W. E. Goldman. 1991. Histoplasma variation and adaptive strategies for parasitism: new perspectives on histoplasmosis. Clin. Microbiol. Rev. 4:411-421.
10. Eissenberg, L. G., J. L. West, J. P. Woods, and W. E. Goldman. 1991. Infection of P388D1 macrophages and respiratory epithelial cells by Histoplasma capsulatum: selection of avirulent variants and their potential role in persistent histoplasmosis. Infect. Immun. 59:1639-1646.
11. Fasoli, M. O. F., D. Kerridge, and J. F. Ryley. 1990. Pathogenicity of 5-fluorocytosine resistant strains of Candida albicans. J. Med. Vet. Mycol. 28:27-34.
12. Gale, C. A., C. M. Bendel, M. McClellan, M. Hauser, J. M. Becker, J. Berman, and M. K. Hostetter. 1998. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INTI. Science 279:1355-1358.
13. Goodwin, R. A., Jr., and R. M. Des Prez. 1978. Histoplasmosis. Am. Rev. Respir. Dis. 117:929-956.
14. Gowen, J. W., J. Stadler, H. H. Plough, and H. N. Miller. 1953. Virulence and immunizing capacity of Salmonella typhimurium as related to mutations in metabolic requirements. Genetics 38:531-549.
15. Graybill, J. R. 1988. Histoplasmosis and AIDS. J. Infect. Dis. 158:623-626.
16. Ivanovics, G., E. Marjai, and A. Dobozy. 1968. The growth of purine mutants of Bacillus anthracis in the body of the mouse. J. Gen. Microbiol. 53:147-162.
17. Johnson, P. C., N. Khardori, A. F. Najjar, F. Butt, P. W. A. Mansell, and G. A. Sarosi. 1988. Progressive disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. Am. J. Med. 85:152-157.
18. Kauffman, C. A., K. S. Isreal, J. W. Smith, A. C. White, J. Schwartz, and G. F. Brooks. 1978. Histoplasmosis in immunosuppressed patients. Am. J. Med. 64:923-932.
19. Kimberlin, C. L., A. R. Hairiri, H. O. Hempel, and N. L. Goodman. 1981. Interactions between Histoplasma capsulatum and macrophages from normal and treated mice: comparison of mycelial and yeast phases in alveolar macrophages. Infect. Immun. 34:6-10.
20. Kirsch, D. R., and R. R. Whitney. 1991. Pathogenicity of Candida albicans auxotrophic mutants in experimental infections. Infect. Immun. 59:3297-3300.
21. Klimpel, K. R., and W. E. Goldman. 1987. Isolation and characterization of spontaneous avirulent variants of Histoplasma capsulatum. Infect. Immun. 55:528-533.
22. Kohler, J. R., and G. R. Fink. 1996. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc. Natl. Acad. Sci. USA 93:13223-13228.
23. Kwon-Chung, K. J., and W. B. Hill. 1970. Studies on the pink adenine-deficient strains of Candida albicans. I. Cultural and morphological characteristics. Sabouraudia 8:48-59.
24. Lambowitz, A. M., G. S. Kobayashi, A. Painter, and G. Medoff. 1983. Possible relationship of morphogenesis in the pathogenic fungus, Histoplasma capsulatum, to heat shock response. Nature 303:806-808.
25. Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
26. Manning, M., C. B. Snoddy, and R. A. Fromtling. 1983. Comparative pathogenicity of auxotrophic mutants of Candida albicans. Can. J. Microbiol. 30: 31-35.
27. Marquis, H., H. G. A. Bouwer, D. J. Hinrichs, and D. A. Portnoy. 1993. Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants. Infect. Immun. 61:3756-3760.
28. Medoff, G., G. S. Kobayashi, A. Painter, and S. Travis. 1987. Morphogenesis and pathogenicity of Histoplasma capsulatum. Infect. Immun. 55:1355-1358.
29. Medoff, G., B. Maresca, A. M. Lambowitz, G. Kobayashi, A. Painter, M. Sacco, and L. Carratu. 1986. Correlation between pathogenicity and temperature sensitivity in different strains of Histoplasma capsulatum. J. Clin. Investig. 78:1638-1647.
30. Medoff, G., M. Sacco, B. Maresco, D. Schlessinger, A. Painter, G. S. Kobayashi, and L. Carratu. 1986. Irreversible block of the mycelial-to-yeast phase transition of Histoplasma capsulatum. Science 231:476-479.
31. Newman, S. L., C. Bucher, J. Rhodes, and W. E. Bullock. 1990. Phagocytosis of Histoplasma capsulatum yeasts and microconidia by human cultured macrophages and alveolar macrophages. Cellular cytoskeleton required for attachment and ingestion. J. Clin. Investig. 85:223-230.
32. Newman, S. L., and L. Gootee. 1992. Colony-stimulating factors activate human macrophages to inhibit growth of Histoplasma capsulatum yeasts. Infect. Immun. 60:4593-4597.
33. Newman, S. L., L. Gootee, G. Brunner, and G. S. Deepe, Jr. 1994. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J. Clin. Investig. 93:1422-1429.
34. Newman, S. L., L. Gootee, C. Bucher, and W. E. Bullock. 1991. Inhibition of intracellular growth of Histoplasma capsulatum yeast cells by cytokine-activated human monocytes and macrophages. Infect. Immun. 59:737-741.
35. Newman, S. L., L. Gootee, C. Kidd, G. M. Ciraolo, and R. Morris. 1997. Activation of human macrophage fungistatic activity against Histoplasma capsulatum upon adherence to type 1 collagen matrices. J. Immunol. 158: 1779-1786.
36. Newman, S. L., L. Gootee, R. Morris, and W. E. Bullock. 1981. Digestion of Histoplasma capsulatum yeasts by human macrophages. J. Immunol. 149: 574-580.
37. Perfect, J. R., D. L. Toffaletti, and T. H. Rude. 1993. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61:4446-4451.
38. Rhodes, J. C., and D. H. Howard. 1980. Isolation and characterization of arginine auxotrophs of Cryptococcus neoformans. Infect. Immun. 27:910-914.
39. Rodgers, F. G., and F. C. Gibson III. 1993. Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells. Can. J. Microbiol. 39:718-722.
40. Sarachek, A. 1964. Promotion or retardation of the growth of adenine auxotrophs of Candida albicans. Antonie Leeuwenhoek 30:289-302.
41. Shepherd, M. G. 1985. Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections. Infect. Immun. 50: 541-544.
42. Smith, J. G., D. M. Magee, D. M. Williams, and J. R. Graybill. 1990. Tumor necrosis factor-α plays a role in host defense against Histoplasma capsulatum. J. Infect. Dis. 162:1349-1353.
43. Straley, S. C., and R. R. Brubaker. 1982. Localization in Yersinia pestis of peptides associated with virulence. Infect. Immun. 36:129-135.
44. Tewari, R. P., and F. J. Berkout. 1972. Comparative pathogenesis of albino and brown types of Histoplasma capsulatum for mice. J. Infect. Dis. 125:504-508.
45. Varma, A., J. C. Edman, and K. J. Kwon-Chung. 1992. Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans. Infect. Immun. 60:1101-1108.
46. Wheat, L. J. 1988. Histoplasmosis. Infect. Dis. Clin. N. Am. 2:841-859.
47. Wheat, L. J. 1995. Endemic mycosis in AIDS: a clinical review. Clin. Microbiol. Rev. 8:146-159.
48. Wolf, J. E., A. L. Abegg, S. J. Travis, G. S. Kobayashi, and J. R. Little. 1989. Effects of Histoplasma capsulatum on murine macrophage functions: inhibition of macrophage priming, oxidative burst, and antifungal activities. Infect. Immun. 57:513-519.
49. Wolf, J. E., V. Kerchberger, G. S. Kobayashi, and J. R. Little. 1987. Modulation of the macrophage oxidative burst by Histoplasma capsulatum. J. Immunol. 138:582-586.
50. Woods, J. P., and W. E. Goldman. 1992. In vivo generation of linear plasmids with addition of telomeric sequences by Histoplasma capsulatum. Mol. Microbiol. 6:3603-3610.
51. Woods, J. P., and W. E. Goldman. 1993. Autonomous replication of foreign DNA in Histoplasma capsulatum: role of native telomeric sequences. J. Bacteriol. 175:636-641.
52. Woods, J. P., E. L. Heinecke, and W. E. Goldman. 1998. Electrotransformation and expression of bacterial genes encoding hygromycin phosphotransferase and β-galactosidase in the pathogenic fungus Histoplasma capsulatum. Infect. Immun. 66:1697-1707.
53. Hc gene by allelic replacement. J. Bacteriol. 180:5135-5143.
54. Worsham, P. L., and W. E. Goldman. 1988. Selection and characterization of ura5 mutants of Histoplasma capsulatum. Mol. Gen. Genet. 214:348-352.
55. Worsham, P. L., and W. E. Goldman. 1990. Development of a genetic transformation system for Histoplasma capsulatum: complementation of uracil auxotrophy. Mol. Gen. Genet. 221:358-362.